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First colombian multicentric newborn screening for congenital toxoplasmosis

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dc.creatorGómez-Marin, Jorge Enriquespa
dc.creatorde-la-Torre, Alejandraspa
dc.creatorAngel-Muller, Edithspa
dc.creatorRubio, Jorgespa
dc.creatorArenas, Jaimespa
dc.creatorOsorio, Elkinspa
dc.creatorNuñez, Lilianspa
dc.date.accessioned2020-08-19T14:43:36Z
dc.date.available2020-08-19T14:43:36Z
dc.date.created2011-05-31spa
dc.description.abstractAims To determine the incidence of congenital toxoplasmosis in Colombian newborns from 19 hospital or maternal child health services from seven different cities of five natural geographic regions (Caribbean, Central, Andean, Amazonia and Eastern). Materials and Methods We collected 15,333 samples from umbilical cord blood between the period of March 2009 to May 2010 in 19 different hospitals and maternal-child health services from seven different cities. We applied an IgM ELISA assay (Vircell, Spain) to determine the frequency of IgM anti Toxoplasma. The results in blood cord samples were confirmed either by western blot and repeated ELISA IgM assay. In a sub-sample of 1,613 children that were negative by the anti-Toxoplasma IgM assay, the frequency of specific anti-Toxoplasma IgA by the ISAGA assay was determined. All children with positive samples by IgM, IgA, clinical diagnosis or treatment during pregnancy were recalled for confirmatory tests after day 10 of life. Results 61 positive samples for specific IgM (0.39%) and 9 positives for IgA (0.5%) were found. 143 questionnaires were positive for a clinical diagnosis or treatment for toxoplasmosis during pregnancy. 109 out of the 218 children that had some of the criteria for postnatal confirmatory tests were followed. Congenital toxoplasmosis infection was confirmed in 15 children: 7 were symptomatic, and three of them died before the first month of life (20% of lethality). A significant correlation was found between a high incidence of markers for congenital toxoplasmosis and higher mean annual rainfall for the city. Conclusions Incidence for congenital toxoplasmosis is significantly different between hospitals or maternal child health services from different cities in Colombia. Mean annual rainfall was correlated with incidence of congenital toxoplasmosis.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1371/journal.pntd.0001195
dc.identifier.issnISSN: 1935-2727
dc.identifier.issnEISSN: 1935-2735
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/27738
dc.language.isoengspa
dc.publisherPLOS Public Library of Sciencespa
dc.relation.citationIssueNo. 5
dc.relation.citationStartPagee1195
dc.relation.citationTitlePLoS Neglected Tropical Diseases
dc.relation.citationVolumeVol. 5
dc.relation.ispartofPLoS Neglected Tropical Diseases, ISSN: 1935-2727;EISSN: 1935-2735, Vol.5, No.5 (May 2011); pp. e1195spa
dc.relation.urihttps://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0001195&type=printablespa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.sourcePLoS Neglected Tropical Diseasesspa
dc.source.instnameinstname:Universidad del Rosario
dc.source.reponamereponame:Repositorio Institucional EdocUR
dc.subject.keywordToxoplasmosisspa
dc.subject.keywordCitiesspa
dc.subject.keywordUmbilical cordspa
dc.subject.keywordEpidemiologyspa
dc.subject.keywordNeonatesspa
dc.subject.keywordColombiaspa
dc.subject.keywordPregnancyspa
dc.subject.keywordBloodspa
dc.titleFirst colombian multicentric newborn screening for congenital toxoplasmosisspa
dc.title.TranslatedTitlePrimer cribado neonatal multicéntrico colombiano de toxoplasmosis congénitaspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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