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Prevalence of cervical HPV infection in women with systemic lupus erythematosus: A systematic review and meta-analysis

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dc.creatorGarcía-Carrasco M.spa
dc.creatorMendoza-Pinto C.spa
dc.creatorRojas-Villarraga A.spa
dc.creatorMolano González, Nicolásspa
dc.creatorVallejo-Ruiz V.spa
dc.creatorMunguía-Realpozo P.spa
dc.creatorColombo A.L.spa
dc.creatorCervera R.spa
dc.date.accessioned2020-05-26T00:01:01Z
dc.date.available2020-05-26T00:01:01Z
dc.date.created2019spa
dc.description.abstractObjective: The objectives of this systematic review and meta-regression were: 1) to compare the prevalence of cervical HPV infection between SLE patients and healthy controls and 2) to evaluate the relationship between cervical HPV infection and traditional and SLE-related risk factors for cervical HPV infection in these patients. Methods: We conducted a systematic literature review (PubMed, Cochrane Library, Embase, Virtual Health Library and SciELO databases) following PRISMA guidelines and using meta-regression to investigate the pooled prevalence of cervical HPV infection in adult women with SLE. The articles included were independently evaluated by two investigators who extracted information on study characteristics, defined outcomes, risk of bias and summarized strength of evidence [Quality of evidence using the Oxford Centre for evidence-based medicine (EBM) Levels of Evidence]. Using meta-regression, we further analyzed whether factors such as multiple sexual partners and immunosuppressive therapy were associated with HPV prevalence. We evaluated the quality of evidence included using the Oxford Centre for EBM levels of evidence. Pooled odds ratios (ORs) and 95% confidence intervals (CI) were calculated for studies providing data on HPV prevalence in women with SLE and in healthy controls. Results: A total of 687 articles were identified; 9 full-text articles examining the prevalence of cervical HPV infection in SLE women were included, comprising 751 SLE women. Eight studies employed PCR using general primers. The HPV prevalence varied from 3.1% to 80.7%. In the random effects meta-analysis, the pooled prevalence of cervical HPV infection in SLE vs. controls was 34.15% (95% CI: 19.6%–52.5%) vs. 15.3% (95% CI 0.79–27.8%), OR = 2.87 (95% CI: 2.20–3.76) p and lt;.0001, with large between-study heterogeneity (I2 = 95.4%). When only SLE women were evaluated, meta-regression showed no significant differences between patients with and without a background of multiple sexual partners and any immunosuppressive therapy. In addition, the prevalence of cervical HPV infection did not significantly differ between SLE patients on azathioprine or cyclophosphamide. Conclusions: This meta-analysis suggests that the prevalence of cervical HPV infection is higher in SLE women than in healthy controls. However, multiple sexual partners and any immunosuppressive therapy or specific immunosuppressive treatment (azathioprine and cyclophosphamide) were not associated with the prevalence of cervical HPV infection. © 2018 Elsevier B.V.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1016/j.autrev.2018.09.001
dc.identifier.issn15689972
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/23300
dc.language.isoengspa
dc.publisherElsevier B.V.spa
dc.relation.citationEndPage191
dc.relation.citationIssueNo. 2
dc.relation.citationStartPage184
dc.relation.citationTitleAutoimmunity Reviews
dc.relation.citationVolumeVol. 18
dc.relation.ispartofAutoimmunity Reviews, ISSN:15689972, Vol.18, No.2 (2019); pp. 184-191spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85058622922&doi=10.1016%2fj.autrev.2018.09.001&partnerID=40&md5=d606916a20649aba312d307d3980b262spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordAzathioprinespa
dc.subject.keywordsystemiceng
dc.subject.keywordCyclophosphamidespa
dc.subject.keywordAdultspa
dc.subject.keywordCochrane libraryspa
dc.subject.keywordConcurrent sexual partnershipspa
dc.subject.keywordControlled studyspa
dc.subject.keywordEmbasespa
dc.subject.keywordEvidence based medicinespa
dc.subject.keywordFemalespa
dc.subject.keywordHumanspa
dc.subject.keywordImmunosuppressive treatmentspa
dc.subject.keywordInfection riskspa
dc.subject.keywordInformation retrievalspa
dc.subject.keywordMedlinespa
dc.subject.keywordMeta analysis (topic)spa
dc.subject.keywordPapillomavirus infectionspa
dc.subject.keywordPrevalencespa
dc.subject.keywordReviewspa
dc.subject.keywordRisk assessmentspa
dc.subject.keywordSystematic reviewspa
dc.subject.keywordSystemic lupus erythematosusspa
dc.subject.keywordUterine cervicitisspa
dc.subject.keywordComplicationspa
dc.subject.keywordMeta analysisspa
dc.subject.keywordPapillomavirus infectionspa
dc.subject.keywordPathologyspa
dc.subject.keywordRisk factorspa
dc.subject.keywordSystemic lupus erythematosusspa
dc.subject.keywordAdultspa
dc.subject.keywordFemalespa
dc.subject.keywordHumansspa
dc.subject.keywordLupus erythematosuseng
dc.subject.keywordPapillomavirus infectionsspa
dc.subject.keywordPrevalencespa
dc.subject.keywordRisk factorsspa
dc.subject.keywordHuman papillomavirus infectionspa
dc.subject.keywordMeta-regressionsspa
dc.subject.keywordSystemic lupus erythematosusspa
dc.titlePrevalence of cervical HPV infection in women with systemic lupus erythematosus: A systematic review and meta-analysisspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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