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Lack of association between TNF-308 polymorphism and the clinical and immunological characteristics of systemic lupus erythematosus and primary Sjögren's syndrome

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dc.creatorTobón G.J.spa
dc.creatorCorrea P.A.spa
dc.creatorGomez L.M.spa
dc.creatorAnaya, Juan-Manuelspa
dc.date.accessioned2020-05-26T00:04:14Z
dc.date.available2020-05-26T00:04:14Z
dc.date.created2005spa
dc.description.abstractObjective: To investigate the previously reported association of tumor necrosis factor alpha (TNF) -308 single nucleotide polymorphism (SNP) with the clinical course and immunological features in patients with systemic lupus erythematosus (SLE) and primary Sjögren's syndrome (pSS). Methods: The studied group consisted of 113 consecutive SLE and 65 pSS patients. TNF -308 SNP was determined by the polymerase chain reaction-restriction fragment length polymorphism technique. Clinical and immunological characteristics were assessed according to a standard protocol that included disease activity (SLEDAI) and damage (SLICC Damage Index). Serum TNF? levels were measured in samples collected from 32 patients with SLE and 16 with pSS by enzyme-linked immunosorbent assay. Results: The TNF2 allele (A) was observed in 46% and 54% of SLE and pSS patients, respectively. We failed to find any significant association between the -308 SNP and disease manifestations, the presence of autoantibodies or cytokine levels in either group. Conclusion: TNF -308 SNP (TNF2) does not exhibit a significant influence on the disease course or immunological response in SLE and pSS. Other genetic and/or environmental factors seem to be required and to be more important than TNF2 allele for the progression of these diseases.eng
dc.format.mimetypeapplication/pdf
dc.identifier.issn0392856X
dc.identifier.issn1593098X
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/23669
dc.language.isoengspa
dc.relation.citationEndPage344
dc.relation.citationIssueNo. 3
dc.relation.citationStartPage339
dc.relation.citationTitleClinical and Experimental Rheumatology
dc.relation.citationVolumeVol. 23
dc.relation.ispartofClinical and Experimental Rheumatology, ISSN:0392856X, 1593098X, Vol.23, No.3 (2005); pp. 339-344spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-20444455423&partnerID=40&md5=e199285473e2eca428e16c665574e628spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordAutoantibodyspa
dc.subject.keywordsystemiceng
dc.subject.keywordTumor necrosis factorspa
dc.subject.keywordsingle nucleotideeng
dc.subject.keywordAdultspa
dc.subject.keywordAllelespa
dc.subject.keywordArticlespa
dc.subject.keywordBlood samplingspa
dc.subject.keywordClinical featurespa
dc.subject.keywordClinical protocolspa
dc.subject.keywordControlled studyspa
dc.subject.keywordDisease activityspa
dc.subject.keywordDisease coursespa
dc.subject.keywordEnvironmental factorspa
dc.subject.keywordEnzyme linked immunosorbent assayspa
dc.subject.keywordFemalespa
dc.subject.keywordGenetic analysisspa
dc.subject.keywordHumanspa
dc.subject.keywordImmune responsespa
dc.subject.keywordImmunologyspa
dc.subject.keywordMajor clinical studyspa
dc.subject.keywordMalespa
dc.subject.keywordPolymerase chain reactionspa
dc.subject.keywordPriority journalspa
dc.subject.keywordProtein analysisspa
dc.subject.keywordProtein blood levelspa
dc.subject.keywordRestriction fragment length polymorphismspa
dc.subject.keywordSingle nucleotide polymorphismspa
dc.subject.keywordSjoegren syndromespa
dc.subject.keywordSystemic lupus erythematosusspa
dc.subject.keywordAdultspa
dc.subject.keywordEnzyme-linked immunosorbent assayspa
dc.subject.keywordFemalespa
dc.subject.keywordGenetic predisposition to diseasespa
dc.subject.keywordHealth statusspa
dc.subject.keywordHumansspa
dc.subject.keywordLupus erythematosuseng
dc.subject.keywordMalespa
dc.subject.keywordPolymorphismeng
dc.subject.keywordSeverity of illness indexspa
dc.subject.keywordSjogren's syndromespa
dc.subject.keywordTumor necrosis factor-alphaspa
dc.subject.keywordPolymorphismspa
dc.subject.keywordPrimary sjögren's syndromespa
dc.subject.keywordSystemic lupus erythematosusspa
dc.subject.keywordTumor necrosis factorspa
dc.titleLack of association between TNF-308 polymorphism and the clinical and immunological characteristics of systemic lupus erythematosus and primary Sjögren's syndromespa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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