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Diabetes Mellitus Type 1 has a Higher Impact on Corneal Endothelial Cell Density and Pachymetry than Diabetes Mellitus Type 2, Independent of Age: A Meta-Regression Model

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dc.creatorAmador-Muñoz, Diana Patricia
dc.creatorConforti, Valentina
dc.creatorMatheus, Luisa Marina
dc.creatorMolano-Gonzalez, Nicolas
dc.creatorPayán-Gómez, César
dc.date.accessioned2025-11-25T16:25:33Z
dc.date.available2025-11-25T16:25:33Z
dc.date.created2021-04-13
dc.date.issued2021-09-22
dc.descriptionObjetivo: Los pacientes con diabetes mellitus (DM) suelen presentar queratopatía. Sin embargo, el compromiso del endotelio corneal en la DM tipo 1 (DM1) y la DM tipo 2 (DM2) no se ha caracterizado adecuadamente hasta el momento. Métodos: Se realizó una búsqueda sistemática de la literatura para encontrar artículos sobre humanos que combinaran la DM1 y/o la DM2 con el endotelio corneal. El período abarcó desde el inicio hasta junio de 2020. La metarregresión evaluó el papel de cada tipo de DM en la densidad de células endoteliales corneales (DCE) y la paquimetría. Los modelos estadísticos incluyeron la edad como modulador para discriminar entre los cambios normales debidos a la edad y el efecto de la enfermedad, y para determinar el impacto de la duración de la enfermedad. Results: The initial search identified 752 records, of which 17 were included in the meta-regression. Patients with T1DM had, on average, 193 cells/mm2 lesser than control patients (P , 0.00001). Patients with T2DM had 151 cells/mm2 less compared with control patients (P , 0.00001). The loss of corneal endothelial cells was expected because the aging was similar in patients with T1DM and T2DM and their control groups. Patients with T1DM and T2DM showed an increase in pachymetry versus control patients, and in both groups, it was associated with the duration of the disease. Conclusions: Both types of DM reduced CED and increased pachymetry. These differences were higher in patients with T1DM versus control patients than patients with T2DM versus control patients. In T1DM, CED reduction was not correlated with the time from diagnosis. In both groups, patients had CED reduction due to aging similar to that of their matched control patients.
dc.description.abstractPurpose: Patients with diabetes mellitus (DM) often have keratopathy. However, the compromise of the corneal endothelium in type 1 DM (T1DM) and type 2 DM (T2DM) has so far not been well characterized. Methods: We performed a systematic literature search to find articles on humans combining T1DM and/or T2DM and the corneal endothelium. The period was from inception to June 2020. The meta-regression evaluated the role of each type of DM on corneal endothelial cell density (CED) and pachymetry. The statistical models included age as a modulator to discriminate between the normal changes due to age and the effect of the disease and to determine the impact of the disease duration. Results: The initial search identified 752 records, of which 17 were included in the meta-regression. Patients with T1DM had, on average, 193 cells/mm2 lesser than control patients (P , 0.00001). Patients with T2DM had 151 cells/mm2 less compared with control patients (P , 0.00001). The loss of corneal endothelial cells was expected because the aging was similar in patients with T1DM and T2DM and their control groups. Patients with T1DM and T2DM showed an increase in pachymetry versus control patients, and in both groups, it was associated with the duration of the disease. Conclusions: Both types of DM reduced CED and increased pachymetry. These differences were higher in patients with T1DM versus control patients than patients with T2DM versus control patients. In T1DM, CED reduction was not correlated with the time from diagnosis. In both groups, patients had CED reduction due to aging similar to that of their matched control patients.
dc.format.extent9 pp
dc.format.mimetypeapplication/pdf
dc.identifier.doihttp://doi.org/10.1097/ICO.0000000000002841
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/47041
dc.language.isoeng
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 International*
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto completo)spa
dc.rights.licenciaEL AUTOR, manifiesta que la obra objeto de la presente autorización es original y la realizó sin violar o usurpar derechos de autor de terceros, por lo tanto la obra es de exclusiva autoría y tiene la titularidad sobre la misma. PARGRAFO: En caso de presentarse cualquier reclamación o acción por parte de un tercero en cuanto a los derechos de autor sobre la obra en cuestión, EL AUTOR, asumirá toda la responsabilidad, y saldrá en defensa de los derechos aquí autorizados; para todos los efectos la universidad actúa como un tercero de buena fe. EL AUTOR, autoriza a LA UNIVERSIDAD DEL ROSARIO, para que en los términos establecidos en la Ley 23 de 1982, Ley 44 de 1993, Decisión andina 351 de 1993, Decreto 460 de 1995 y demás normas generales sobre la materia, utilice y use la obra objeto de la presente autorización. -------------------------------------- POLITICA DE TRATAMIENTO DE DATOS PERSONALES. Declaro que autorizo previa y de forma informada el tratamiento de mis datos personales por parte de LA UNIVERSIDAD DEL ROSARIO para fines académicos y en aplicación de convenios con terceros o servicios conexos con actividades propias de la academia, con estricto cumplimiento de los principios de ley. Para el correcto ejercicio de mi derecho de habeas data cuento con la cuenta de correo habeasdata@urosario.edu.co, donde previa identificación podré solicitar la consulta, corrección y supresión de mis datos.spa
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.source.bibliographicCitationInternational Diabetes Federation. IDF Diabetes Atlas. International Diabetes Federation Web Site. 2019. Available at: https://www. diabetesatlas.org/upload/resources/material/20200302_133351_ IDFATLAS9e-final-web.pdf. Accessed November 3, 2020.
dc.source.bibliographicCitationPowers AC, Niswender KD, Evans-Molina C. Diabetes mellitus: diagnosis, classification, and pathophysiology. In: Jameson JL, Fauci AS, Kasper DL, et al. eds. Harrison’s Principles of Internal Medicine. New York, NY: McGraw-Hill Education; 2018:2850–2858.
dc.source.bibliographicCitationJeganathan VS, Wang JJ, Wong TY. Ocular associations of diabetes other than diabetic retinopathy. Diabetes Care. 2008;31:1905–1912.
dc.source.bibliographicCitationAldrich BT, Schlötzer-Schrehardt U, Skeie JM, et al. Mitochondrial and morphologic alterations in native human corneal endothelial cells associated with diabetes mellitus. Invest Opthalmology Vis Sci. 2017; 58:2130–2138.
dc.source.bibliographicCitationDawson DG, John LU, Edelhauser HF. Cornea and sclera. In: Levin L, ed. Adler’s Physiology of the Eye. St Louis, MI: W B Saunders Company; 2011:71–130.
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subjectDiabetes mellitus tipo 1
dc.subjectDiabetes mellitus tipo 2
dc.subjectEndotelio
dc.subjectCórnea
dc.subjectMetanálisis
dc.subject.keywordDiabetes mellitus type 1
dc.subject.keywordDiabetes mellitus type 2
dc.subject.keywordEndothelium
dc.subject.keywordCorneal
dc.subject.keywordMeta-analysis
dc.titleDiabetes Mellitus Type 1 has a Higher Impact on Corneal Endothelial Cell Density and Pachymetry than Diabetes Mellitus Type 2, Independent of Age: A Meta-Regression Model
dc.typejournalArticle
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículo
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