Ítem
Solo Metadatos

The forkhead-box family of transcription factors: Key molecular players in colorectal cancer pathogenesis 06 Biological Sciences 0604 Genetics 11 Medical and Health Sciences 1112 Oncology and Carcinogenesis 06 Biological Sciences 0601 Biochemistry and Cell Biology

Mostrar el registro sencillo de la publicación
dc.creatorLaissue, Paul
dc.date.accessioned2020-05-25T23:57:06Z
dc.date.available2020-05-25T23:57:06Z
dc.date.created2019spa
dc.description.abstractColorectal cancer (CRC) is the third most commonly occurring cancer worldwide and the fourth most frequent cause of death having an oncological origin. It has been found that transcription factors (TF) dysregulation, leading to the significant expression modifications of genes, is a widely distributed phenomenon regarding human malignant neoplasias. These changes are key determinants regarding tumour's behaviour as they contribute to cell differentiation/proliferation, migration and metastasis, as well as resistance to chemotherapeutic agents. The forkhead box (FOX) transcription factor family consists of an evolutionarily conserved group of transcriptional regulators engaged in numerous functions during development and adult life. Their dysfunction has been associated with human diseases. Several FOX gene subgroup transcriptional disturbances, affecting numerous complex molecular cascades, have been linked to a wide range of cancer types highlighting their potential usefulness as molecular biomarkers. At least 14 FOX subgroups have been related to CRC pathogenesis, thereby underlining their role for diagnosis, prognosis and treatment purposes. This manuscript aims to provide, for the first time, a comprehensive review of FOX genes' roles during CRC pathogenesis. The molecular and functional characteristics of most relevant FOX molecules (FOXO, FOXM1, FOXP3) have been described within the context of CRC biology, including their usefulness regarding diagnosis and prognosis. Potential CRC therapeutics (including genome-editing approaches) involving FOX regulation have also been included. Taken together, the information provided here should enable a better understanding of FOX genes' function in CRC pathogenesis for basic science researchers and clinicians. © 2019 The Author(s).eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1186/s12943-019-0938-x
dc.identifier.issn14764598
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/22607
dc.language.isoengspa
dc.publisherBioMed Central Ltd.spa
dc.relation.citationIssueNo. 1
dc.relation.citationTitleMolecular Cancer
dc.relation.citationVolumeVol. 18
dc.relation.ispartofMolecular Cancer, ISSN:14764598, Vol.18, No.1 (2019)spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85059797841&doi=10.1186%2fs12943-019-0938-x&partnerID=40&md5=f1d0f005866696a8bfed98cf5af1e6e1spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordCisplatinspa
dc.subject.keywordneoplasticeng
dc.subject.keywordForkhead box protein m1spa
dc.subject.keywordForkhead transcription factorspa
dc.subject.keywordOncoproteinspa
dc.subject.keywordTranscription factor foxospa
dc.subject.keywordTranscription factor foxp3spa
dc.subject.keywordForkhead transcription factorspa
dc.subject.keywordAkt1 genespa
dc.subject.keywordAkt2 genespa
dc.subject.keywordApoptosisspa
dc.subject.keywordBinding affinityspa
dc.subject.keywordCancer cellspa
dc.subject.keywordCancer diagnosisspa
dc.subject.keywordCancer growthspa
dc.subject.keywordCancer researchspa
dc.subject.keywordCell cycle g1 phasespa
dc.subject.keywordCell cycle g2 phasespa
dc.subject.keywordCell cycle m phasespa
dc.subject.keywordCell cycle regulationspa
dc.subject.keywordCell cycle s phasespa
dc.subject.keywordCell proliferationspa
dc.subject.keywordClinical researchspa
dc.subject.keywordColon carcinogenesisspa
dc.subject.keywordColorectal cancerspa
dc.subject.keywordCrispr-cas9 systemspa
dc.subject.keywordDna bindingspa
dc.subject.keywordFox genespa
dc.subject.keywordFoxm1 genespa
dc.subject.keywordFoxo genespa
dc.subject.keywordFoxp3 genespa
dc.subject.keywordGene editingspa
dc.subject.keywordGene expression regulationspa
dc.subject.keywordGene functionspa
dc.subject.keywordHumanspa
dc.subject.keywordImmunityspa
dc.subject.keywordLymphocytic infiltrationspa
dc.subject.keywordNonhumanspa
dc.subject.keywordPdpk1 genespa
dc.subject.keywordProtein phosphorylationspa
dc.subject.keywordRegulatory t lymphocytespa
dc.subject.keywordReviewspa
dc.subject.keywordSciencespa
dc.subject.keywordTranscription regulationspa
dc.subject.keywordTumor microenvironmentspa
dc.subject.keywordTumor suppressor genespa
dc.subject.keywordAnimalspa
dc.subject.keywordCell motionspa
dc.subject.keywordColorectal tumorspa
dc.subject.keywordGeneticsspa
dc.subject.keywordPathologyspa
dc.subject.keywordPrognosisspa
dc.subject.keywordAnimalsspa
dc.subject.keywordCell movementspa
dc.subject.keywordCell proliferationspa
dc.subject.keywordColorectal neoplasmsspa
dc.subject.keywordForkhead transcription factorsspa
dc.subject.keywordGene expression regulationeng
dc.subject.keywordHumansspa
dc.subject.keywordPrognosisspa
dc.subject.keywordColorectal cancerspa
dc.subject.keywordForkhead transcription factorsspa
dc.subject.keywordMolecular aetiologyspa
dc.titleThe forkhead-box family of transcription factors: Key molecular players in colorectal cancer pathogenesis 06 Biological Sciences 0604 Genetics 11 Medical and Health Sciences 1112 Oncology and Carcinogenesis 06 Biological Sciences 0601 Biochemistry and Cell Biologyspa
dc.title.TranslatedTitleThe forkhead-box family of transcription factors: Key molecular players in colorectal cancer pathogenesis 06 Biological Sciences 0604 Genetics 11 Medical and Health Sciences 1112 Oncology and Carcinogenesis 06 Biological Sciences 0601 Biochemistry and Cell Biologyeng
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
Archivos
Colecciones
Artículos