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Initial combination therapy with metformin plus Colesevelam in drug-naïve hispanic patients with early type 2 diabetes

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dc.creatorRosenstock, Juliospa
dc.creatorHernandez-Triana, Ericspa
dc.creatorHandelsman, Yehudaspa
dc.creatorMisir, Soamnauthspa
dc.creatorJones, Michael R.spa
dc.creatorNagendran, Sukumarspa
dc.date.accessioned2020-05-25T23:58:22Z
dc.date.available2020-05-25T23:58:22Z
dc.date.created2012spa
dc.description.abstractObjective: To evaluate initial combination therapy with metformin plus colesevelam in drug-naïve Hispanic patients with type 2 diabetes mellitus. Research Design and Methods: Patients self-identifed as Hispanic from a previous study were included in this exploratory post hoc analysis. Patients were randomized to metformin plus colesevelam or metformin plus placebo. The primary effcacy parameter was the mean change in glycated hemoglobin (HbA1c) levels from baseline. Results: Metformin plus colesevelam had a greater mean HbA1c reduction (-1.2 ± 0.1%) than metformin plus placebo (-0.8 ± 0.1%; P = 0.001) from mean baselines of 7.7% and 7.6%, respectively. Low-density lipoprotein cholesterol (LDL-C), non-high-density lipoprotein cholesterol, total cholesterol, and apolipoprotein (apo) B levels were also reduced (P and lt; 0.0001 for all), while triglyceride (P and lt; 0.0001) and apoA-I (P and lt; 0.05) levels were increased with metformin plus colesevelam treatment compared with metformin plus placebo. With metformin plus colesevelam versus metformin plus placebo, more patients achieved an HbA1c of, 7.0% (75% vs 56%) and LDL-C of, 100 mg/dL (49% vs 14%; both P, 0.05). Conclusion: Metformin plus colesevelam may be an effective initial treatment option for Hispanic patients with early type 2 diabetes mellitus. © Postgraduate Medicine.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.3810/pgm.2012.07.2560
dc.identifier.issn325481
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/22849
dc.language.isoengspa
dc.publisherMedquest Communications LLCspa
dc.relation.citationEndPage13
dc.relation.citationIssueNo. 4
dc.relation.citationStartPage7
dc.relation.citationTitlePostgraduate Medicine
dc.relation.citationVolumeVol. 124
dc.relation.ispartofPostgraduate Medicine, ISSN:325481, Vol.124, No.4 (2012); pp. 7-13spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84871672045&doi=10.3810%2fpgm.2012.07.2560&partnerID=40&md5=21be1c7dca5cef8c3cdceae6cbfe21b5spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordApolipoprotein A1spa
dc.subject.keywordType 2eng
dc.subject.keywordColesevelamspa
dc.subject.keywordHemoglobin a1cspa
dc.subject.keywordLow density lipoprotein cholesterolspa
dc.subject.keywordMetforminspa
dc.subject.keywordPlacebospa
dc.subject.keywordTriacylglycerolspa
dc.subject.keywordAllylaminespa
dc.subject.keywordAntidiabetic agentspa
dc.subject.keywordCholesterolspa
dc.subject.keywordColesevelamspa
dc.subject.keywordDrug derivativespa
dc.subject.keywordGlycosylated hemoglobinspa
dc.subject.keywordHypocholesterolemic agentspa
dc.subject.keywordLipoproteinspa
dc.subject.keywordMetforminspa
dc.subject.keywordAbdominal distensionspa
dc.subject.keywordAbdominal painspa
dc.subject.keywordAdultspa
dc.subject.keywordArticlespa
dc.subject.keywordCholesterol blood levelspa
dc.subject.keywordCohort analysisspa
dc.subject.keywordConstipationspa
dc.subject.keywordControlled studyspa
dc.subject.keywordDiarrheaspa
dc.subject.keywordDrug dose titrationspa
dc.subject.keywordDrug efficacyspa
dc.subject.keywordDrug responsespa
dc.subject.keywordDrug safetyspa
dc.subject.keywordDrug withdrawalspa
dc.subject.keywordDyspepsiaspa
dc.subject.keywordFemalespa
dc.subject.keywordFlatulencespa
dc.subject.keywordGastritisspa
dc.subject.keywordHispanicspa
dc.subject.keywordHumanspa
dc.subject.keywordMajor clinical studyspa
dc.subject.keywordMalespa
dc.subject.keywordMulticenter study (topic)spa
dc.subject.keywordNauseaspa
dc.subject.keywordNon insulin dependent diabetes mellitusspa
dc.subject.keywordPost hoc analysisspa
dc.subject.keywordRandomized controlled trial (topic)spa
dc.subject.keywordTriacylglycerol blood levelspa
dc.subject.keywordVomitingspa
dc.subject.keywordBloodspa
dc.subject.keywordClinical trialspa
dc.subject.keywordControlled clinical trialspa
dc.subject.keywordDouble blind procedurespa
dc.subject.keywordDrug combinationspa
dc.subject.keywordEthnologyspa
dc.subject.keywordHispanicspa
dc.subject.keywordRandomized controlled trialspa
dc.subject.keywordTreatment outcomespa
dc.subject.keywordAllylaminespa
dc.subject.keywordAnticholesteremic Agentsspa
dc.subject.keywordCholesterolspa
dc.subject.keywordDiabetes Mellituseng
dc.subject.keywordDouble-Blind Methodspa
dc.subject.keywordDrug Therapyeng
dc.subject.keywordFemalespa
dc.subject.keywordHemoglobin Aeng
dc.subject.keywordHispanic Americansspa
dc.subject.keywordHumansspa
dc.subject.keywordHypoglycemic Agentsspa
dc.subject.keywordLipoproteinsspa
dc.subject.keywordMalespa
dc.subject.keywordMetforminspa
dc.subject.keywordTreatment Outcomespa
dc.subject.keywordBile acid sequestrantspa
dc.subject.keywordColesevelamspa
dc.subject.keywordHispanicspa
dc.subject.keywordMetforminspa
dc.subject.keywordType 2 diabetes mellitusspa
dc.titleInitial combination therapy with metformin plus Colesevelam in drug-naïve hispanic patients with early type 2 diabetesspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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