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Association between Secondary and Primary Sjögren's Syndrome in a Large Collection of Lupus Families

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dc.creatorAggarwal, Rachna
dc.creatorAnaya, Juan-Manuel
dc.creatorKoelsch, Kristi A.
dc.creatorKurien, Biji T.
dc.creatorScofield, R. Hal
dc.creator.googleAggarwal R., Anaya J.-M., Koelsch K.A., Kurien B.T., Scofield R.H.spa
dc.date.accessioned2023-08-04T17:50:44Z
dc.date.available2023-08-04T17:50:44Z
dc.date.created2015-02-13
dc.date.issued2015-07-12
dc.descriptionSystemic lupus erythematosus (SLE) and Sjögren's syndrome (SS) share clinical and immunogenetic features and may occur together. We undertook this study to determine the risk of primary SS among SLE-unaffected relatives of SLE patients and whether or not primary and secondary SS tended to occur in the same families. Methods. We collected clinical and serological data on 2694 SLE patients, 7390 SLE-unaffected relatives of the SLE patients, and 1470 matched controls. Results. Of the 2694 subjects with SLE, 548 had secondary SS, while 71 of their 7390 SLE-unaffected relatives had primary SS. None of the 1470 controls had SS as defined herein (p = 5 × 10-5 compared to SLE-unaffected relatives). Of the 71 SLE-unaffected relatives with primary SS, 18 (25.3%) had an SLE-affected family member with secondary SS, while only 530 of the 7319 (7.2%) SLE-unaffected relatives without SS did so (p = 1 × 10-8). Conclusion. Among families identified for the presence of SLE, primary and secondary SS tend to occur within the same families. These results highlight the commonalities between these two forms of SS, which in fact correspond to the same disease. © 2015 Rachna Aggarwal et al.spa
dc.format.extent5 pp
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1155/2015/298506
dc.identifier.issn2090-0422
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/40288
dc.language.isoengspa
dc.relation.ispartofAutoimmune Diseases, ISSN: 2090-0422, Vol. 2015 (2015)spa
dc.relation.urihttp://downloads.hindawi.com/journals/ad/2015/298506.pdfspa
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 International*
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto completo)spa
dc.rights.cchttps://creativecommons.org/licenses/by/3.0/spa
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.source.bibliographicCitationFox, R.I., Sjögren's syndrome (2005) The Lancet, 366 (9482), pp. 321-331
dc.source.bibliographicCitationM. V. Jonsson, K. Skarstein, R. Jonsson, and J. G. Brun, “Serological implications of germinal center-like structures in primary Sjogren’s syndrome,” ¨ The Journal of Rheumatology, vol. 34, no. 10, pp. 2044–2049, 2007
dc.source.bibliographicCitationM. N. Lazarus, D. Robinson, V. Mak, H. Møller, and D. A. Isenberg, “Incidence of cancer in a cohort of patients with primary Sjogren’s syndrome,” ¨ Rheumatology, vol. 45, no. 8, pp. 1012–1015, 2006
dc.source.bibliographicCitationH. Nakamura, A. Kawakami, and K. Eguchi, “Mechanisms of autoantibody production and the relationship between autoantibodies and the clinical manifestations in Sjogren’s syndrome,” ¨ Translational Research, vol. 148, no. 6, pp. 281–288, 2006
dc.source.instnameinstname:Universidad del Rosario
dc.source.reponamereponame:Repositorio Institucional EdocUR
dc.subject.keywordAutoantibody
dc.subject.keywordFemale
dc.subject.keywordCohort Analysis
dc.subject.keywordControlled Study
dc.subject.keywordDisease Association
dc.subject.keywordHuman
dc.subject.keywordMajor Clinical Study
dc.subject.keywordMale
dc.subject.keywordPriority Journal
dc.subject.keywordRisk Assessment
dc.subject.keywordSerology
dc.subject.keywordSjoegren Syndrome
dc.subject.keywordSystemic Lupus Erythematosus
dc.titleAssociation between Secondary and Primary Sjögren's Syndrome in a Large Collection of Lupus Familiesspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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