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Low genetic polymorphism of merozoite surface proteins 7 and 10 in Colombian Plasmodium vivax isolates

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dc.creatorGarzón-Ospina D.spa
dc.creatorRomero-Murillo L.spa
dc.creatorTobón L.F.spa
dc.creatorPatarroyo M.A.spa
dc.date.accessioned2020-05-26T00:11:18Z
dc.date.available2020-05-26T00:11:18Z
dc.date.created2011spa
dc.description.abstractThe merozoite surface protein (MSP) family is involved in the initial interaction between merozoites and erythrocytes in Plasmodium species, its members are therefore becoming major targets for vaccine development. Considering that antigens included in a subunit malaria vaccine should be both accessible to the immune system and lack genetic diversity or have very limited polymorphism, we have analyzed the genetic diversity of three msp genes (msp-7A, msp-7K and msp-10) in different geographical regions of Colombia. The results showed that these genes follow the neutral model of evolution and also display low genetic diversity. The strong conservation found for msp-7 haplotypes in isolates from geographically different regions further suggests that these proteins could be good components of a vaccine against Plasmodium vivax malaria, thereby avoiding strain-specific immune responses. © 2010 Elsevier B.V.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1016/j.meegid.2010.12.002
dc.identifier.issn15671348
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/24294
dc.language.isoengspa
dc.relation.citationEndPage531
dc.relation.citationIssueNo. 2
dc.relation.citationStartPage528
dc.relation.citationTitleInfection, Genetics and Evolution
dc.relation.citationVolumeVol. 11
dc.relation.ispartofInfection, Genetics and Evolution, ISSN:15671348, Vol.11, No.2 (2011); pp. 528-531spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-79951953688&doi=10.1016%2fj.meegid.2010.12.002&partnerID=40&md5=c39402701ec8261bbec40aa60e4eef6bspa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordMembrane proteinspa
dc.subject.keywordprotozoaneng
dc.subject.keywordMerozoite surface protein 7aspa
dc.subject.keywordMerozoite surface protein 7kspa
dc.subject.keywordUnclassified drugspa
dc.subject.keywordArticlespa
dc.subject.keywordColombiaspa
dc.subject.keywordControlled studyspa
dc.subject.keywordGenetic conservationspa
dc.subject.keywordGenetic polymorphismspa
dc.subject.keywordGenetic variabilityspa
dc.subject.keywordGeographyspa
dc.subject.keywordHaplotypespa
dc.subject.keywordNonhumanspa
dc.subject.keywordNucleotide sequencespa
dc.subject.keywordPlasmodium vivaxspa
dc.subject.keywordPriority journalspa
dc.subject.keywordAntigenseng
dc.subject.keywordColombiaspa
dc.subject.keywordGenetic variationspa
dc.subject.keywordGenotypespa
dc.subject.keywordHost-parasite interactionsspa
dc.subject.keywordHumansspa
dc.subject.keywordMalaria vaccinesspa
dc.subject.keywordMalariaeng
dc.subject.keywordMembrane proteinsspa
dc.subject.keywordMolecular sequence dataspa
dc.subject.keywordPlasmodium vivaxspa
dc.subject.keywordPolymerase chain reactionspa
dc.subject.keywordPolymorphismeng
dc.subject.keywordProtozoan proteinsspa
dc.subject.keywordPlasmodium vivaxspa
dc.subject.keywordGenetic polymorphismspa
dc.subject.keywordMerozoite surface proteinspa
dc.subject.keywordPspa
dc.subject.keywordVivaxspa
dc.subject.keywordVaccine candidatespa
dc.titleLow genetic polymorphism of merozoite surface proteins 7 and 10 in Colombian Plasmodium vivax isolatesspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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