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Pigment epithelium-derived factor: Clinical significance in estrogen-dependent tissues and its potential in cancer therapy

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dc.creatorFranco-Chuaire M.L.spa
dc.creatorRamírez Clavijo, Sandra Rocíospa
dc.creatorChuaire-Noack L.spa
dc.date.accessioned2020-05-25T23:55:44Z
dc.date.available2020-05-25T23:55:44Z
dc.date.created2015spa
dc.description.abstractPigment epithelium-derived factor (PEDF) is a glycoprotein that belongs to the family of noninhibitory serpins. The broad spectrum of PEDF biological activity is evident when considering its effects in promoting cell survival and proliferation, as well as its antiangiogenic, antitumor, and antimetastatic properties. Although the structural domains of the PEDF gene that mediate such diverse effects and their mechanisms of action have not been completely elucidated, there is a large body of evidence describing their diverse range of activities; this evidence combined with the regulation of PEDF expression by sex steroids and their receptors have led to the idea that PEDF is not only a diagnostic and prognostic marker for certain diseases such as cancer, but is also a potential therapeutic target. In this manner, this paper aims to generally review the regulation of PEDF expression and PEDF interactions, as well as the findings that relate PEDF to the role of estrogens and estrogen receptors. In addition, this manuscript will review major advances toward potential therapeutic applications of PEDF. © 2015, Mashhad University of Medical Sciences. All rights reserved.eng
dc.format.mimetypeapplication/pdf
dc.identifier.issn20083874
dc.identifier.issn20083866
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/22193
dc.language.isoengspa
dc.publisherMashhad University of Medical Sciencesspa
dc.relation.citationEndPage855
dc.relation.citationIssueNo. 9
dc.relation.citationStartPage837
dc.relation.citationTitleIranian Journal of Basic Medical Sciences
dc.relation.citationVolumeVol. 18
dc.relation.ispartofIranian Journal of Basic Medical Sciences, ISSN:20083874, 20083866, Vol.18, No.9 (2015); pp. 837-855spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84943525036&partnerID=40&md5=186e806ed9eb1eb2e7327d396ef754c5spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordEstrogenspa
dc.subject.keywordPigment epithelium derived factorspa
dc.subject.keywordAngiogenesisspa
dc.subject.keywordArticlespa
dc.subject.keywordCancer therapyspa
dc.subject.keywordCell cycle regulationspa
dc.subject.keywordCell proliferationspa
dc.subject.keywordCell survivalspa
dc.subject.keywordCellular distributionspa
dc.subject.keywordEndometriumspa
dc.subject.keywordHumanspa
dc.subject.keywordMammary glandspa
dc.subject.keywordNuclear localization signalspa
dc.subject.keywordOxidative stressspa
dc.subject.keywordProtein expressionspa
dc.subject.keywordPublicationspa
dc.subject.keywordSenescencespa
dc.subject.keywordSignal transductionspa
dc.subject.keywordAnti-tumorigenesisspa
dc.subject.keywordAntiangiogenesisspa
dc.subject.keywordEstrogen receptorsspa
dc.subject.keywordEstrogensspa
dc.subject.keywordHormonal regulationspa
dc.subject.keywordPedfspa
dc.subject.keywordSynthetic peptidesspa
dc.titlePigment epithelium-derived factor: Clinical significance in estrogen-dependent tissues and its potential in cancer therapyspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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