Ítem
Acceso Abierto

Introducing polyautoimmunity: secondary autoimmune diseases no longer exist

Mostrar el registro sencillo de la publicación
dc.audienceComunidad Rosaristaspa
dc.creatorRojas-Villarraga, Adriana
dc.creatorAmaya-Amaya, Jenny-Carolina
dc.creatorRodriguez-Rodriguez, Alberto
dc.creatorMantilla, Rubén D.
dc.creatorAnaya, Juan-Manuel
dc.creator.googleRojas-Villarraga, Adriana
dc.creator.googleAmaya-Amaya, Jenny
dc.creator.googleRodriguez-Rodriguez, Alberto
dc.creator.googleMantilla, Rubén D.
dc.creator.googleAnaya, Juan-Manuel
dc.date.accessioned2014-08-12T16:54:07Z
dc.date.available2014-08-12T16:54:07Z
dc.date.created2012
dc.date.issued2012
dc.description.abstractSimilar pathophysiological mechanisms within autoimmune diseases have stimulated searches for common genetic roots. Polyautoimmunity is defined as the presence of more than one autoimmune disease in a single patient. When three or more autoimmune diseases coexist, this condition is called multiple autoimmune syndrome (MAS). We analyzed the presence of polyautoimmunity in 1,083 patients belonging to four autoimmune disease cohorts. Polyautoimmunity was observed in 373 patients (34.4%). Autoimmune thyroid disease (AITD) and Sjögren's syndrome (SS) were the most frequent diseases encountered. Factors significantly associated with polyautoimmunity were female gender and familial autoimmunity. Through a systematic literature review, an updated search was done for all MAS cases (January 2006–September 2011). There were 142 articles retrieved corresponding to 226 cases. Next, we performed a clustering analysis in which AITD followed by systemic lupus erythematosus and SS were the most hierarchical diseases encountered. Our results indicate that coexistence of autoimmune diseases is not uncommon and follows a grouping pattern. Polyautoimmunity is the term proposed for this association of disorders, which encompasses the concept of a common origin for these diseases.eng
dc.format.mediumRecurso electrónicospa
dc.format.mimetypeapplication/pdf
dc.format.tipoDocumentospa
dc.identifier.issnISSN:2090-0430
dc.identifier.urihttp://repository.urosario.edu.co/handle/10336/8811
dc.language.isoeng
dc.publisherUniversidad del Rosariospa
dc.relation.citationTitleAutoimmune Diseases
dc.relation.ispartofAutoimmune Diseases, ISSN 2090-04-30, 2012spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto completo)spa
dc.rights.licenciaEL AUTOR, manifiesta que la obra objeto de la presente autorización es original y la realizó sin violar o usurpar derechos de autor de terceros, por lo tanto la obra es de exclusiva autoría y tiene la titularidad sobre la misma.spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.ddcIncidencia & prevención de la enfermedad
dc.subject.decsPoliautoinmunidadspa
dc.subject.decsEnfermedades autoinmunesspa
dc.subject.decsInmunologíaspa
dc.titleIntroducing polyautoimmunity: secondary autoimmune diseases no longer existspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/acceptedVersion
dc.type.spaArtículospa
Archivos
Bloque original
Mostrando1 - 1 de 1
Miniatura
Nombre:
Introducing Polyautoimmunity.pdf
Tamaño:
1.3 MB
Formato:
Adobe Portable Document Format
Descripción:
Descargar
Colecciones
Artículos