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Human papillomavirus detection from human immunodeficiency virus-infected colombian women's paired urine and cervical samples

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dc.audienceComunidad Rosaristaspa
dc.creatorMunoz, Marina
dc.creatorCamargo, Milena
dc.creatorSoto De Leon, Sara C
dc.creatorSánchez, Ricardo
dc.creatorParra, Diana
dc.creatorPineda, Andrea C.
dc.creatorSussmann, Otto
dc.creatorPerez-Prados, Antonio
dc.creatorPatarroyo, Manuel E.
dc.creatorPatarroyo, Manuel A.
dc.creator.googleMunoz, Marina
dc.creator.googleCamargo, Milena
dc.creator.googleSoto De Leon, Sara C
dc.creator.googleSanchez, Ricardo
dc.creator.googleParra, Diana
dc.creator.googlePineda, Andrea C.
dc.creator.googleSussmann, Otto
dc.creator.googlePerez-Prados, Antonio
dc.creator.googlePatarroyo, Manuel E.
dc.creator.googlePatarroyo, Manuel A.
dc.date.accessioned2014-08-12T12:52:56Z
dc.date.available2014-08-12T12:52:56Z
dc.date.created2013-02-13
dc.date.issued2013
dc.description.abstractInfection, coinfection and type-specific human papillomavirus (HPV) distribution was evaluated in human immunodeficiency virus (HIV)-positive women from paired cervical and urine samples. Paired cervical and urine samples (n = 204) were taken from HIV-positive women for identifying HPV-DNA presence by using polymerase chain reaction (PCR) with three generic primer sets (GP5+/6+, MY09/11 and pU1M/2R). HPV-positive samples were typed for six high-risk HPV (HR-HPV) (HPV-16, -18, -31, -33, -45 and -58) and two low-risk (LR-HPV) (HPV-6/11) types. Agreement between paired sample results and diagnostic performance was evaluated. HPV infection prevalence was 70.6% in cervical and 63.2% in urine samples. HPV-16 was the most prevalent HPV type in both types of sample (66.7% in cervical samples and 62.0% in urine) followed by HPV-31(47.2%) in cervical samples and HPV-58 (35.7%) in urine samples. There was 55.4% coinfection (infection by more than one type of HPV) in cervical samples and 40.2% in urine samples. Abnormal Papanicolau smears were observed in 25.3% of the women, presenting significant association with HPV-DNA being identified in urine samples. There was poor agreement of cervical and urine sample results in generic and type-specific detection of HPV. Urine samples provided the best diagnosis when taking cytological findings as reference. In conclusion including urine samples could be a good strategy for ensuring adherence to screening programs aimed at reducing the impact of cervical cancer, since this sample is easy to obtain and showed good diagnostic performance.eng
dc.format.mediumRecurso electrónicospa
dc.format.mimetypeapplication/pdf
dc.format.tipoDocumentospa
dc.identifier.doihttps://doi.org/10.1371/journal.pone.0056509
dc.identifier.issn1932-6203
dc.identifier.urihttp://repository.urosario.edu.co/handle/10336/8781
dc.language.isoeng
dc.publisherUniversidad del Rosariospa
dc.relation.citationIssueNo. 2
dc.relation.citationTitlePLOS ONE
dc.relation.citationVolumeVol. 8
dc.relation.ispartofPLOS ONE ISSN: 1932-6203 V. 8 N. 2 Feb 13, 2013spa
dc.relation.urihttp://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0056509
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto completo)spa
dc.rights.licenciaEL AUTOR, manifiesta que la obra objeto de la presente autorización es original y la realizó sin violar o usurpar derechos de autor de terceros, por lo tanto la obra es de exclusiva autoría y tiene la titularidad sobre la misma.spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.ddcGinecología & otras especialidades médicas
dc.subject.decsCáncerspa
dc.subject.decsVirus del papiloma humano. VPHspa
dc.subject.decsSíndrome de Inmunodeficiencia Adquirida. SIDAspa
dc.subject.decsEnfermedades infecciosasspa
dc.subject.decsInmunologíaspa
dc.subject.keywordPositive womeneng
dc.subject.keywordHPV infectioneng
dc.subject.keywordDNA detectioneng
dc.subject.keywordPrimer setseng
dc.subject.keywordPCReng
dc.subject.keywordCancereng
dc.titleHuman papillomavirus detection from human immunodeficiency virus-infected colombian women's paired urine and cervical samplesspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/acceptedVersion
dc.type.spaArtículospa
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