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On the contribution of Angola to the initial spread of HIV-1

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dc.creatorPineda-Peña, Andrea-Clemenciaspa
dc.creatorVaranda, Jorgespa
dc.creatorSousa, João Dinisspa
dc.creatorTheys, Kristofspa
dc.creatorBártolo, Inêsspa
dc.creatorLeitner, Thomasspa
dc.creatorTaveira, Nunospa
dc.creatorVandamme, Anne-Miekespa
dc.creatorAbecasis, Ana B.spa
dc.date.accessioned2020-05-26T00:11:25Z
dc.date.available2020-05-26T00:11:25Z
dc.date.created2016spa
dc.description.abstractAngola borders and has long-term links with Democratic Republic of Congo (DRC) as well as high levels of Human Immunodeficiency Virus (HIV) genetic diversity, indicating a potential role in the initial spread of the HIV-1 pandemic. Herein, we analyze 564 C2V3 and 354 pol publicly available sequences from DRC, Republic of Congo (RC) and Angola to better understand the initial spread of the virus in this region. Phylogeographic analyses were performed with the BEAST software. While our results pinpoint the origin of the pandemic to Kinshasa (DRC) around 1906, the introduction of HIV-1 to Angola could have occurred early between the 1910s and 1940s. Furthermore, most of the HIV-1 migrations out of Kinshasa were directed not only to Lubumbashi and Mbuji-Mayi (DRC), but also to Luanda and Brazzaville. Kinshasa census records corroborate these findings, indicating that the early exportation of the virus to Angola might be related to the high number of Angolans in Kinshasa at that time, originated mostly from the North of Angola. In summary, our results place Angola at the epicenter of the early HIV dissemination, together with DRC and RC. © 2016 Elsevier B.V.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1016/j.meegid.2016.08.009
dc.identifier.issn15671348
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/24301
dc.language.isoengspa
dc.publisherElsevier B.V.spa
dc.relation.citationEndPage222
dc.relation.citationStartPage219
dc.relation.citationTitleInfection, Genetics and Evolution
dc.relation.citationVolumeVol. 46
dc.relation.ispartofInfection, Genetics and Evolution, ISSN:15671348, Vol.46,(2016); pp. 219-222spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84996590196&doi=10.1016%2fj.meegid.2016.08.009&partnerID=40&md5=b7ce03fb466764e8fe0e566a619086dcspa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordAngolaspa
dc.subject.keywordAngolanspa
dc.subject.keywordArticlespa
dc.subject.keywordCongospa
dc.subject.keywordControlled studyspa
dc.subject.keywordDemocratic Republic Congospa
dc.subject.keywordHumanspa
dc.subject.keywordHuman immunodeficiency virus 1spa
dc.subject.keywordImmigrantspa
dc.subject.keywordMigrationspa
dc.subject.keywordPandemicspa
dc.subject.keywordPhylogeographyspa
dc.subject.keywordPriority journalspa
dc.subject.keywordSoftwarespa
dc.subject.keywordVirus transmissionspa
dc.subject.keywordClassificationspa
dc.subject.keywordGeneticsspa
dc.subject.keywordHistoryspa
dc.subject.keywordHIV Infectionsspa
dc.subject.keywordHuman immunodeficiency virus 1spa
dc.subject.keywordTransmissionspa
dc.subject.keywordVirologyspa
dc.subject.keywordAngolaspa
dc.subject.keywordCongospa
dc.subject.keywordDemocratic Republic of the Congospa
dc.subject.keywordHistory, 20th Centuryspa
dc.subject.keywordHistory, 21st Centuryspa
dc.subject.keywordHIV Infectionsspa
dc.subject.keywordHIV-1spa
dc.subject.keywordHuman Migrationspa
dc.subject.keywordHumansspa
dc.subject.keywordPhylogeographyspa
dc.subject.keywordAngolaspa
dc.subject.keywordGroup Mspa
dc.subject.keywordHIV-1spa
dc.subject.keywordOriginspa
dc.subject.keywordPhylogeographyspa
dc.titleOn the contribution of Angola to the initial spread of HIV-1spa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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