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Implications of hepatitis C virus subtype 1a migration patterns for virus genetic sequencing policies in Italy

dc.creatorCuypers, Lize
dc.creatorVrancken, Bram
dc.creatorFabeni, Lavinia
dc.creatorMarascio, Nadia
dc.creatorCento, Valeria
dc.creatorDi Maio, Velia Chiara
dc.creatorAragr, Marianna
dc.creatorPineda-Peña, Andrea-Clemencia
dc.creatorSchrooten, Yoeri
dc.creatorVan Laethem, Kristel
dc.creatorBalog, Daniel
dc.creatorFocà, Alfredo
dc.creatorTort, Carlo
dc.creatorNevens, Frederik
dc.creatorPerno, Carlo Federico
dc.creatorOudshoorn, Anne-Mieke
dc.creatorCeccherini-Silberstein, Francesca
dc.creator.googleCuypers, Lizespa
dc.creator.googleVrancken, Bramspa
dc.creator.googleFabeni, Laviniaspa
dc.creator.googleMarascio, Nadiaspa
dc.creator.googleCento, Valeriaspa
dc.creator.googleDi Maio, Velia Chiaraspa
dc.creator.googleAragri, Mariannaspa
dc.creator.googlePineda-Peña, Andrea Clemenciaspa
dc.creator.googleSchrooten, Yoerispa
dc.creator.googleVan Laethem, Kristelspa
dc.creator.googleBalog, Danielspa
dc.creator.googleFocà, Alfredospa
dc.creator.googleTorti, Carlospa
dc.creator.googleNevens, Frederikspa
dc.creator.googlePerno, Carlo Federicospa
dc.creator.googleVandamme, Anne-Miekespa
dc.creator.googleCeccherini-Silberstein, Francescaspa
dc.date.accessioned2020-04-16T00:32:43Z
dc.date.available2020-04-16T00:32:43Z
dc.date.created2017
dc.date.issued2017
dc.description.abstractBackground: In-depth phylogeographic analysis can reveal migration patterns relevant for public health planning. Here, as a model, we focused on the provenance, in the current Italian HCV subtype 1a epidemic, of the NS3 resistance-associated variant (RAV) Q80K, known to interfere with the action of NS3/4A protease inhibitor simeprevir. HCV1a migration patterns were analysed using Bayesian phylodynamic tools, capitalising on newly generated and publicly available time and geo-referenced NS3 encoding virus genetic sequence data. Results: Our results showed that both immigration and local circulation fuel the current Italian HCV1a epidemic. The United States and European continental lineages dominate import into Italy, with the latter taking the lead from the 1970s onwards. Since similar migration patterns were found for Q80K and other lineages, no clear differentiation of the risk for failing simeprevir can be made between patients based on their migration and travel history. Importantly, since HCV only occasionally recombines, these results are readily transferable to the genetic sequencing policy concerning NS5A RAVs. Conclusions: The patient migration and travel history cannot be used to target only part of the HCV1a infected population for drug resistance testing before start of antiviral therapy. Consequently, it may be cost-effective to expand genotyping efforts to all HCV1a infected patients eligible for simeprevir-based therapies. © 2017 The Author(s).eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1186/s12862-017-0913-3
dc.identifier.issn1471-2148
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/21643
dc.language.isoengspa
dc.relation.citationIssueNo. 1
dc.relation.citationTitleBMC Evolutionary Biology
dc.relation.citationVolumeVol. 17
dc.relation.ispartofBMC Evolutionary Biology, ISSN: 1471-2148 Vol. 17, No. 1 (2017)spa
dc.relation.urihttps://bmcevolbiol.biomedcentral.com/track/pdf/10.1186/s12862-017-0913-3spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosario
dc.source.reponamereponame:Repositorio Institucional EdocUR
dc.subjectFilogeografíaspa
dc.subjectPolítica de salud públicaspa
dc.subject.ddcEnfermedadesspa
dc.subject.keywordHCVspa
dc.subject.keywordHCV1aspa
dc.subject.keywordQ80Kspa
dc.subject.keywordPhylogeographyspa
dc.subject.keywordPublic health policyspa
dc.subject.lembVirus de la hepatitis cspa
dc.subject.lembSalud públicaspa
dc.titleImplications of hepatitis C virus subtype 1a migration patterns for virus genetic sequencing policies in Italyspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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