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Decreased brain-derived neurotrophic factor serum concentrations in chronic post-stroke subjects

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dc.creatorLopes Santos, Gabrielaspa
dc.creatorCarmona Alcântara, Carolinaspa
dc.creatorAbreu Silva-Couto, Marcelaspa
dc.creatorGarcía Salazar, Luisa Fernanda
dc.creatorRusso, Thiago Luizspa
dc.date.accessioned2020-08-19T14:42:22Z
dc.date.available2020-08-19T14:42:22Z
dc.date.created2016-12-01spa
dc.description.abstractBackground Brain-derived neurotrophic factor (BDNF) plays a critical role in sensorimotor recovery after a stroke. However, few studies have assessed the circulating BDNF levels in post-stroke humans to understand its changes. This study was conducted to measure BDNF serum concentrations in subjects with chronic hemiparesis, as well as to correlate serum concentrations with age, post-stroke time, total score of Stroke Specific Quality of Life Scale (SS-QOL), mobility subscale score, and motor function of SS-QOL. Methods Seventeen chronic post-stroke subjects matched by age and gender with healthy controls took part in the study. Personal data (age, hemiparesis side, and post-stroke time) were collected, and a physical examination (weight, height, body mass index) and SS-QOL assessment were carried out. On the same day, after the initial evaluation, venous blood samples were collected from the chronic post-stroke subjects and the healthy subjects. The BDNF serum concentrations were measured blindly by enzyme-linked immunosorbent assay. Results Subjects with chronic hemiparesis presented a decrease in BDNF serum compared with healthy subjects (P?<?.01). There was no correlation between BDNF serum levels with post-stroke time, age or quality of life, mobility, and the upper extremity motor function (P?>?.05). BDNF concentrations are related to structural and functional recovery after stroke; thus, this reduction is important to understand the rehabilitation process more clearly. However, more studies are needed considering the genetic variations and other tools to assess motor impairment and functional independence. Conclusion Chronic post-stroke subjects presented a decrease in BDNF serum concentrations, without a correlation with post-stroke time, age, and quality of life.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1016/j.jstrokecerebrovasdis.2016.08.014
dc.identifier.issnISSN: 1052-3057
dc.identifier.issnEISSN: 1532-8511
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/27477
dc.language.isoengspa
dc.publisherElsevierspa
dc.relation.citationEndPage2974
dc.relation.citationIssueNo. 12
dc.relation.citationStartPage2968
dc.relation.citationTitleJournal of Stroke and Cerebrovascular Diseases
dc.relation.citationVolumeVol. 25
dc.relation.ispartofJournal of Stroke and Cerebrovascular Diseases, ISSN: 1052-3057;EISSN: 1532-8511 Vol.25, No.12 (2016); pp. 2968-2974spa
dc.relation.urihttps://www.sciencedirect.com/science/article/abs/pii/S1052305716302865spa
dc.rights.accesRightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.accesoRestringido (Acceso a grupos específicos)spa
dc.sourceJournal of Stroke and Cerebrovascular Diseasesspa
dc.source.instnameinstname:Universidad del Rosario
dc.source.reponamereponame:Repositorio Institucional EdocUR
dc.subject.keywordBrain-derived neurotrophic factorspa
dc.subject.keywordStrokespa
dc.subject.keywordNeuronal plasticityspa
dc.subject.keywordRehabilitationspa
dc.titleDecreased brain-derived neurotrophic factor serum concentrations in chronic post-stroke subjectsspa
dc.title.TranslatedTitleDisminución de las concentraciones séricas del factor neurotrófico derivado del cerebro en sujetos crónicos después de un accidente cerebrovascularspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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