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Exploring the Molecular Aetiology of Preeclampsia by Massive Parallel Sequencing of DNA

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dc.creatorLaissue, Paul
dc.creatorVaiman, Danielspa
dc.date.accessioned2020-05-26T00:05:36Z
dc.date.available2020-05-26T00:05:36Z
dc.date.created2020spa
dc.description.abstractPurpose of Review: This manuscript aims to review (for the first time) studies describing NGS sequencing of preeclampsia (PE) women’s DNA. Recent Findings: Describing markers for the early detection of PE is an essential task because, although associated molecular dysfunction begins early on during pregnancy, the disease’s clinical signs usually appear late in pregnancy. Although several biochemical biomarkers have been proposed, their use in clinical environments is still limited, thereby encouraging research into PE’s genetic origin. Hundreds of genes involved in numerous implantation- and placentation-related biological processes may be coherent candidates for PE aetiology. Next-generation sequencing (NGS) offers new technical possibilities for PE studying, as it enables large genomic regions to be analysed at affordable cost. This technique has facilitated the description of genes contributing to the molecular origin of a significant amount of monogenic and complex diseases. Regarding PE, NGS of DNA has been used in familial and isolated cases, thereby enabling new genes potentially related to the phenotype to be proposed. Summary: For a better understanding of NGS, technical aspects, applications and limitations are presented initially. Thereafter, NGS studies of DNA in familial and non-familial cases are described, including pitfalls and positive findings. The information given here should enable scientists and clinicians to analyse and design new studies permitting the identification of novel clinically useful molecular PE markers. © 2020, Springer Science+Business Media, LLC, part of Springer Nature.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1007/s11906-020-01039-z
dc.identifier.issn15226417
dc.identifier.issn15343111
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/23809
dc.language.isoengspa
dc.publisherSpringerspa
dc.relation.citationIssueNo. 4
dc.relation.citationTitleCurrent Hypertension Reports
dc.relation.citationVolumeVol. 22
dc.relation.ispartofCurrent Hypertension Reports, ISSN:15226417, 15343111, Vol.22, No.4 (2020)spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85081592717&doi=10.1007%2fs11906-020-01039-z&partnerID=40&md5=40d06a8a1113baaf2530ff21a64a4034spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordDnaspa
dc.subject.keywordAcvr2a genespa
dc.subject.keywordAllelespa
dc.subject.keywordAno9 genespa
dc.subject.keywordDna sequencingspa
dc.subject.keywordEnvironmental factorspa
dc.subject.keywordGenespa
dc.subject.keywordGene mutationspa
dc.subject.keywordGenetic associationspa
dc.subject.keywordGenetic codespa
dc.subject.keywordGenetic variationspa
dc.subject.keywordHigh throughput sequencingspa
dc.subject.keywordHumanspa
dc.subject.keywordKhdc3l genespa
dc.subject.keywordMaternal plasmaspa
dc.subject.keywordMolecular pathologyspa
dc.subject.keywordNonhumanspa
dc.subject.keywordNrlp14 genespa
dc.subject.keywordNrlp2 genespa
dc.subject.keywordPlacenta developmentspa
dc.subject.keywordPreeclampsiaspa
dc.subject.keywordReviewspa
dc.subject.keywordTmtc1 genespa
dc.subject.keywordTp53bp1 genespa
dc.subject.keywordTrim28 genespa
dc.subject.keywordZfr2 genespa
dc.subject.keywordGenetic biomarkerspa
dc.subject.keywordMolecular medicinespa
dc.subject.keywordNext-generation sequencing (ngs)spa
dc.subject.keywordPreeclampsiaspa
dc.titleExploring the Molecular Aetiology of Preeclampsia by Massive Parallel Sequencing of DNAspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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