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Far from the madding crowd: The molecular basis for immunological escape of plasmodium falciparum

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dc.creatorPatarroyo M.E.spa
dc.creatorAza-Conde J.spa
dc.creatorMoreno-Vranich A.spa
dc.creatorPabón L.spa
dc.creatorVarela Y.spa
dc.creatorPatarroyo M.A.spa
dc.date.accessioned2020-05-26T00:05:39Z
dc.date.available2020-05-26T00:05:39Z
dc.date.created2017spa
dc.description.abstractLike Thomas Hardy’s famous novel Far from the Madding Crowd, Plasmodium falciparum parasites display their most relevant survival structures (proteins) involved in host cell invasion far away from the immune system’s susceptible regions, displaying tremendous genetic variability, to attract the immune response and escape immune pressure. The 3D structure localisation of the conserved amino acid sequences of this deadly parasite’s most relevant proteins involved in host cell invasion, as well as the location of the highly polymorphic, highly immunogenic regions, clearly demonstrates that such structures are far apart, sometimes 90° to 180° opposite, thereby rendering the immune response useless. It is also shown here that these conserved, functionally-relevant structures are immunologically silent, since no immune response has been induced. © 2017, Caister Academic Press. All rights reserved.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.21775/cimb.022.065
dc.identifier.issn14673037
dc.identifier.issn14673045
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/23813
dc.language.isoengspa
dc.publisherCaister Academic Pressspa
dc.relation.citationEndPage78
dc.relation.citationStartPage65
dc.relation.citationTitleCurrent Issues in Molecular Biology
dc.relation.citationVolumeVol. 22
dc.relation.ispartofCurrent Issues in Molecular Biology, ISSN:14673037, 14673045, Vol.22,(2017); pp. 65-78spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85010930947&doi=10.21775%2fcimb.022.065&partnerID=40&md5=25b87c7556274d999e66ca1804e6da9bspa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordImmune responsespa
dc.subject.keywordprotozoaneng
dc.subject.keywordPlasmodium falciparumspa
dc.subject.keywordAnimalspa
dc.subject.keywordHost parasite interactionspa
dc.subject.keywordImmunologyspa
dc.subject.keywordMalaria falciparumspa
dc.subject.keywordPlasmodium falciparumspa
dc.subject.keywordParasite antigenspa
dc.subject.keywordAnimalsspa
dc.subject.keywordAntigenseng
dc.subject.keywordHost-parasite interactionsspa
dc.subject.keywordMalariaeng
dc.subject.keywordPlasmodium falciparumspa
dc.titleFar from the madding crowd: The molecular basis for immunological escape of plasmodium falciparumspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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