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Simultaneous cytomegalovirus and herpesvirus meningitis in an adolescent immunocompetent patient

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dc.creatorCruz-Acevedo, Diego Andrésspa
dc.creatorVargas Mendoza, Isabellaspa
dc.creatorPinzón Salamanca, Javier Yesidspa
dc.creatorSuescún-Vargas, José Miguelspa
dc.date.accessioned2025-01-26T18:35:08Z
dc.date.available2025-01-26T18:35:08Z
dc.date.created2024-08-30spa
dc.date.issued2024-08-30spa
dc.descriptionBackground: Viral meningitis is an inflammatory condition of the meninges that manifests as neurological dysfunction with variable clinical signs, ranging from mild manifestations (such as headache) to seizures and intracranial hypertension. The clinical presentation can vary with the patient’s age, immune status, and etiology of the disease, with many symptoms being nonspecific. Coinfections in central nervous system (CNS) infections are rare, more commonly observed in immunocompromised patients. We report the first known case of viral meningitis due to concurrent cytomegalovirus (CMV) and herpes simplex virus type 2 (HSV-2) in an immunocompetent adolescent, highlighting a significant clinical consideration in the management of similar cases. Case Description: We present a case from March 2021 involving a 16-year-old previously healthy Latin male adolescent with no known immunity-related abnormalities, who presented diarrhea with macroscopic blood, headache, and fever. He was diagnosed with a rare viral coinfection of CMV and HSV-2 meningitis. Investigations to rule out primary or secondary immunodeficiency showed no abnormalities. The patient received antiviral therapy for 21 days with ganciclovir (5 mg/kg/dose), leading to a favorable outcome without subsequent neurological deficit or adverse events. Conclusions: This case enriches clinical practice by demonstrating effective management in an unlikely host, thereby broadening our understanding of viral meningitis in immunocompetent patients and informing future diagnostic and treatment strategies.spa
dc.format.mimetypeapplication/pdfspa
dc.identifier.doihttps://doi.org/10.21037/pm-23-67spa
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/44838
dc.language.isoengspa
dc.publisherPediatric Medicinespa
dc.relation.ispartofPediatric Medicinespa
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internationalspa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccessspa
dc.rights.accesoAbierto (Texto Completo)spa
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/spa
dc.sourcePediatric Medicinespa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subjectPediatríaspa
dc.subjectperinaltologíaspa
dc.subjectsalud infantilspa
dc.titleSimultaneous cytomegalovirus and herpesvirus meningitis in an adolescent immunocompetent patientspa
dc.typearticlespa
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersionspa
dc.type.spaArtículospa
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