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Correlation between methotrexate pharmacokinetic parameters, and clinical and biological status in rheumatoid arthritis patients

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dc.creatorAnaya, Juan-Manuelspa
dc.creatorBologna, C.spa
dc.creatorJorgensen, C.spa
dc.creatorAlric, Rspa
dc.creatorSany, J.spa
dc.date.accessioned2020-08-19T14:42:11Z
dc.date.available2020-08-19T14:42:11Z
dc.date.created1995spa
dc.description.abstractTo determine the correlation between the pharmacokinetic (PK) parameters of methotrexate (MTX), clinical status and laboratory test results in rheumatoid arthritis (RA) patients.22 patients (4 M/18F, mean age: 50 +/- 12 years, mean duration of RA: 8.5 +/- 6.5 years, mean duration on MTX: 8 +/- 10 months) were included in a prospective study. The mean dose of MTX administered was 6 +/- 0.7 mg/m2 of body area/week. No patient received any nonsteroidal antiinflammatory drug (NSAID). Blood and urine samples were collected over 24 hours (9 blood samples). The MTX concentrations were assayed by fluorescence polarization immunoassay. Clinical parameters (Ritchie articular index, morning stiffness, joint pain count, joint swelling count), hematological, liver and renal function tests, and ESR were recorded. Correlations between the patients' PK parameters, laboratory tests and clinical status were carried out using Pearson's correlation coefficient test.A significant correlation was observed between the Ritchie articular index, morning stiffness and the area under the curve (p = 0.009 and p = 0.026, respectively). No correlation was found with the other parameters.These results suggest that when the patient's disease activity is higher, the AUC becomes more important, reflecting a greater body exposure to MTX.eng
dc.format.mimetypeapplication/pdf
dc.identifier.issnISSN: 0392-856X
dc.identifier.issnEISSN: 1593-098X
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/27434
dc.language.isoengspa
dc.publisherEurope PMCspa
dc.relation.citationEndPage470
dc.relation.citationIssueNo. 4
dc.relation.citationStartPage465
dc.relation.citationTitleClinical and Experimental Rheumatology
dc.relation.citationVolumeVol. 13
dc.relation.ispartofClinical and Experimental Rheumatology, ISSN: 0392-856X; EISSN: 1593-098X, Vol.13, No.4 (1995);pp. 465-470spa
dc.relation.urihttps://europepmc.org/article/med/7586778spa
dc.rights.accesRightsinfo:eu-repo/semantics/closedAccess
dc.rights.accesoBloqueado (Texto referencial)spa
dc.sourceClinical and Experimental Rheumatologyspa
dc.source.instnameinstname:Universidad del Rosario
dc.source.reponamereponame:Repositorio Institucional EdocUR
dc.subject.keywordPharmacokineticspa
dc.subject.keywordRheumatoid arthritisspa
dc.titleCorrelation between methotrexate pharmacokinetic parameters, and clinical and biological status in rheumatoid arthritis patientsspa
dc.title.TranslatedTitleCorrelación entre los parámetros farmacocinéticos del metotrexato y el estado clínico y biológico en pacientes con artritis reumatoidespa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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