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Major Histocompatibility Complex Class II (DRB3) Genetic Diversity in Spanish Morucha and Colombian Normande Cattle Compared to Taurine and Zebu Populations

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dc.creatorBohórquez, Michel Davidspa
dc.creatorOrdoñez, Diegospa
dc.creatorSuarez Martinez, Carlos Fernando
dc.creatorVicente, Belénspa
dc.creatorVieira, Carmenspa
dc.creatorLópez-Abán, Juliospa
dc.creatorMuro, Antoniospa
dc.creatorOrdóñez, Ivánspa
dc.creatorPatarroyo, Manuel A.
dc.date.accessioned2020-05-26T00:08:26Z
dc.date.available2020-05-26T00:08:26Z
dc.date.created2020spa
dc.description.abstractBovine leukocyte antigens (BoLA) have been used as disease markers and immunological traits in cattle due to their primary role in pathogen recognition by the immune system. A higher MHC allele diversity in a population will allow presenting a broader peptide repertoire. However, loss of overall diversity due to domestication process can decrease a population’s peptide repertoire. Within the context of zebu and taurine cattle populations, BoLA-DRB3 genetic diversity in Spanish Morucha and Colombian Normande cattle was analyzed and an approach to estimate functional diversity was performed. Sequence-based typing was used for identifying 29, 23, 27, and 28 alleles in Spanish Morucha, Nariño-, Boyacá-, and Cundinamarca-Normande cattle, respectively. These breeds had remarkably low heterozygosity levels and the Hardy-Weinberg principle revealed significant heterozygote deficiency. FST and DA genetic distance showed that Colombian Normande populations had greater variability than other phenotypically homogeneous breeds, such as Holstein. It was also found that Spanish Morucha cattle were strongly differentiated from other cattle breeds. Spanish Morucha had greater divergence in the peptide-binding region regarding other cattle breeds. However, peptide-binding region covariation indicated that the potential peptide repertoire seemed equivalent among cattle breeds. Despite the genetic divergence observed, the extent of the potential peptide repertoire in the cattle populations studied appears to be similar and thus their pathogen recognition potential should be equivalent, suggesting that functional diversity might persist in the face of bottlenecks imposed by domestication and breeding. © Copyright © 2020 Bohórquez, Ordoñez, Suárez, Vicente, Vieira, López-Abán, Muro, Ordóñez and Patarroyo.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.3389/fgene.2019.01293
dc.identifier.issn16648021
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/24084
dc.language.isoengspa
dc.publisherFrontiers Media S.A.spa
dc.relation.citationTitleFrontiers in Genetics
dc.relation.citationVolumeVol. 10
dc.relation.ispartofFrontiers in Genetics, ISSN:16648021, Vol.10,(2020)spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85078107738&doi=10.3389%2ffgene.2019.01293&partnerID=40&md5=b0fd1a0ba99f31158872c7c9304f1f17spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordMajor histocompatibility antigen class 2spa
dc.subject.keywordAllelespa
dc.subject.keywordArticlespa
dc.subject.keywordBola drb3 genespa
dc.subject.keywordCattle breedspa
dc.subject.keywordColombian normande cattlespa
dc.subject.keywordControlled studyspa
dc.subject.keywordGenespa
dc.subject.keywordGene frequencyspa
dc.subject.keywordGene locusspa
dc.subject.keywordGene sequencespa
dc.subject.keywordGenetic distancespa
dc.subject.keywordGenetic parametersspa
dc.subject.keywordGenetic variabilityspa
dc.subject.keywordHardy weinberg equilibriumspa
dc.subject.keywordHeterozygosityspa
dc.subject.keywordNonhumanspa
dc.subject.keywordPopulation distributionspa
dc.subject.keywordPopulation structurespa
dc.subject.keywordSpanish morucha cattlespa
dc.subject.keywordTaurine cattlespa
dc.subject.keywordZebuspa
dc.subject.keywordBola-drb3spa
dc.subject.keywordCattlespa
dc.subject.keywordGenetic diversityspa
dc.subject.keywordGenetic resistancespa
dc.subject.keywordMhcspa
dc.subject.keywordPeptide-binding regionspa
dc.titleMajor Histocompatibility Complex Class II (DRB3) Genetic Diversity in Spanish Morucha and Colombian Normande Cattle Compared to Taurine and Zebu Populationsspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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