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Bone mineral density and vertebral fractures in patients with systemic lupus erythematosus : A systematic review and meta-regression

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dc.creatorMendoza-Pinto, C.
dc.creatorRojas-Villarraga, A.
dc.creatorMolano González, Nicolás
dc.creatorJimenez-Herrera, E.A.
dc.creatorDe La Luz Leon-Vazquez, M.
dc.creatorMontiel-Jarquõn, A.
dc.creatorGarcõa-Carrasco, M.
dc.creatorCervera, R.
dc.creatorMendoza-Pinto, Claudia
dc.creatorRojas-Villarraga, Adriana
dc.creatorMolano González, Nicolás
dc.creatorJiménez-Herrera, Erick A.
dc.creatorLeón-Vázquez, María de la Luz
dc.creatorMontiel-Jarquín, Alvaro
dc.creatorGarcía-Carrasco, Mario
dc.creatorCervera, Ricard
dc.creator.googleMendoza-Pinto, Claudia
dc.creator.googleRojas-Villarraga, Adriana
dc.creator.googleMolano-González, Nicolás
dc.creator.googleJiménez-Herrera, Erick A.
dc.creator.googleLeón-Vázquez, María de la Luz
dc.creator.googleMontiel-Jarquín, Álvaro
dc.creator.googleGarcía-Carrasco, Mario
dc.creator.googleCervera, Ricard
dc.date.accessioned2019-09-24T15:03:47Z
dc.date.available2019-09-24T15:03:47Z
dc.date.created2018
dc.date.issued2018-06-13
dc.description.abstractBackground Observational studies have indicated a high but heterogeneous prevalence of low bone mineral density (BMD) and vertebral fractures (VF) in patients with systemic lupus erythematosus (SLE). Therefore, the objectives of this systematic review and meta-regression were: 1) to compare BMD between SLE patients and healthy controls and 2) to evaluate the relationship between BMD and glucocorticoid therapy and VF in SLE patients. Methods and findings Articles were identified from electronic databases (PubMed, Embase, VHL, SciELO and the Cochrane Library). Prospective longitudinal and cross-sectional studies were considered for review. We evaluated the quality of the evidence included using the Oxford Centre for evidence- based medicine (EBM) Levels of Evidence. In total, 38 articles were identified and analyzed (3442 SLE cases and 6198 controls) in the analysis of BMD (9232 women and 408 men). There were significant differences in mean BMD between SLE patients and controls. BMD mean difference in cases/controls: -0.0566 95% CI (-0.071, -0.0439; p = > 0.0001). When only SLE patients were analyzed, the BMD did not significantly differ between patients who had or had not received glucocorticoid (GCT) therapy. 694 SLE patients were included in the analysis of VF (189 with VF vs. 505 without VF). Patients with VF had lower BMD than patients without VF (BMD mean difference without VF/with VF: 0.033 (95%CI: 0.006±0.060); p-value: 0.0156). Conclusions Patients with SLE had lower BMD than healthy controls. Moreover, SLE patients with VF had lower BMD than patients without VF. However, our data did not show that GCT therapy had an impact on BMD. © 2018 van den Berg et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1371/journal.pone.0196113
dc.identifier.issn1932-6203
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/20324
dc.language.isoengspa
dc.relation.citationTitlePLoS ONE
dc.relation.citationVolumeVol. 13
dc.relation.ispartofPLoS ONE, ISSN:1932-6203, Vol. 13 (2018)spa
dc.relation.urihttps://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0196113&type=printablespa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.bibliographicCitationSinigaglia, L., Varenna, M., Binelli, L., Zucchi, F., Ghiringhella, D., Gallazzi, M., Determinants of bone mass in systemic lupus erythematosus: A cross sectional study on premenopausal women (1999) J Rheumatol., 26, pp. 1280-1284. , PMID: 10381043spa
dc.source.instnameinstname:Universidad del Rosario
dc.source.reponamereponame:Repositorio Institucional EdocUR
dc.subjectGlucocorticoidesspa
dc.subjectDensidad oseaspa
dc.subjectTerapia con corticosteroidesspa
dc.subjectAsociación de la enfermedadspa
dc.subject.ddcFisiología humanaspa
dc.subject.keywordGlucocorticoidspa
dc.subject.keywordBone densityspa
dc.subject.keywordCorticosteroid therapyspa
dc.subject.keywordDisease associationspa
dc.subject.keywordEvidence based medicinespa
dc.subject.keywordGenderspa
dc.subject.keywordHumanspa
dc.subject.keywordMedication therapy managementspa
dc.subject.keywordReviewspa
dc.subject.keywordSpine fracturespa
dc.subject.keywordSystematic reviewspa
dc.subject.keywordSystemic lupus erythematosusspa
dc.subject.lembGlucocorticoidesspa
dc.subject.lembLupus eritematosospa
dc.subject.lembFracturasspa
dc.titleBone mineral density and vertebral fractures in patients with systemic lupus erythematosus : A systematic review and meta-regressionspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículo de revisión spa
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