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Pathogenicity Levels of Colombian Strains of Candida auris and Brazilian Strains of Candida haemulonii Species Complex in Both Murine and Galleria mellonella Experimental Models

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dc.creatorMuñoz Henao, Julián Esteban
dc.creatorRamirez, Lauraspa
dc.creatorDias, Lucasspa
dc.creatorRivas, Lauraspa
dc.creatorRamos, Liviaspa
dc.creatorSantos, L.S.spa
dc.creatorPelleschi Taborda, Carlosspa
dc.creatorParra-Giraldo, Claudia Mspa
dc.date.accessioned2020-08-19T14:40:03Z
dc.date.available2020-08-19T14:40:03Z
dc.date.created2020-07-10spa
dc.description.abstractCandida auris and Candida haemulonii complex (C. haemulonii, C. haemulonii var. vulnera and C. duobushaemulonii) are phylogenetically related species that share some physiological features and habits. In the present study, we compared the virulence of these yeast species using two different experimental models: (i) Galleria mellonella larvae to evaluate the survival rate, fungal burden, histopathology and phagocytosis index and (ii) BALB/c mice to evaluate the survival. In addition, the fungal capacity to form biofilm over an inert surface was analyzed. Our results showed that in both experimental models, the animal survival rate was lower when infected with C. auris strains than the C. haemulonii species complex. The hemocytes of G. mellonella showed a significantly reduced ability to phagocytize the most virulent strains forming the C. haemulonii species complex. Interestingly, for C. auris, it was impossible to measure the phagocytosis index due to a general lysis of the hemocytes. Moreover, it was observed a greater capability of biofilm formation by C. auris compared to C. haemulonii species complex. In conclusion, we observed that C. auris and C. haemulonii complex have different levels of pathogenicity in the experimental models employed in the present study.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.3390/jof6030104
dc.identifier.issnISSN: 2309-608X
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/26692
dc.language.isoengspa
dc.publisherEuropean Confederation of Medical Mycologyspa
dc.relation.citationEndPage14
dc.relation.citationIssueNo. 14
dc.relation.citationStartPage1
dc.relation.citationTitleJournal of Fungi
dc.relation.citationVolumeVol. 6
dc.relation.ispartofJournal of Fungi, ISSN: 2309-608X, Vol.6, No.14 (2020); pp. 1-14spa
dc.relation.urihttps://www.mdpi.com/2309-608X/6/3/104/htmspa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.sourceJournal of Fungispa
dc.source.instnameinstname:Universidad del Rosario
dc.source.reponamereponame:Repositorio Institucional EdocUR
dc.subject.keywordCandida aurisspa
dc.subject.keywordCandida haemulonii species complexspa
dc.subject.keywordVirulencespa
dc.subject.keywordCandidiasisspa
dc.subject.keywordBiofilmspa
dc.subject.keywordGalleria mellonellaspa
dc.titlePathogenicity Levels of Colombian Strains of Candida auris and Brazilian Strains of Candida haemulonii Species Complex in Both Murine and Galleria mellonella Experimental Modelsspa
dc.title.alternativePathogenicity Levels of Colombian Strains of Candida auris and Brazilian Strains of Candida haemulonii Species Complex in Both Murine and Galleria mellonella Experimental Modelsspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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