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Whole-genome sequencing to determine origin of multinational outbreak of Sarocladium kiliense bloodstream infections

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dc.creatorEtienne, Kizee A.
dc.creatorRoe, Chandler C.
dc.creatorSmith, Rachel M.
dc.creatorVallabhaneni, Snigdha
dc.creatorDuarte-Rey, Carolina
dc.creatorEscandón, Patricia
dc.creatorCastañeda, Elizabeth
dc.creatorGómez, Beatriz L.
dc.creatorBedout, Catalina de
dc.creatorLópez, Luisa F.
dc.creatorSalas, Valentina
dc.creatorHederra, Luz Maria
dc.creatorFernández, Jorge
dc.creatorPidal, Paola
dc.creatorHormazabel, Juan Carlos
dc.creatorOtaíza-O’Ryan, Fernando
dc.creatorVannberg, Fredrik O.
dc.creatorGillece, John
dc.creatorLemmer, Darrin
dc.creatorDriebe, Elizabeth M.
dc.creatorEngelthaler, David M.
dc.creatorLitvintseva, Anastasia P.
dc.creator.googleEtienne, Kizee A.spa
dc.creator.googleRoe, Chandler C.spa
dc.creator.googleSmith, Rachel M.spa
dc.creator.googleVallabhaneni, Snigdhaspa
dc.creator.googleDuarte, Carolinaspa
dc.creator.googleEscandón, Patriciaspa
dc.creator.googleCastañeda, Elizabethspa
dc.creator.googleGómez, Beatriz L.spa
dc.creator.googleBedout, Catalina despa
dc.creator.googleLópez, Luisa F.spa
dc.creator.googleSalas, Valentinaspa
dc.creator.googleHederra, Luz Mariaspa
dc.creator.googleFernández, Jorgespa
dc.creator.googlePidal, Paolaspa
dc.creator.googleHormazabel, Juan Carlosspa
dc.creator.googleOtaíza-O’ryan, Fernandospa
dc.creator.googleVannberg, Fredrick O.spa
dc.creator.googleGillece, Johnspa
dc.creator.googleLemmer, Darrinspa
dc.creator.googleDriebe, Elizabeth M.spa
dc.creator.googleEngelthaler, David M.spa
dc.creator.googleLitvintseva, Anastasia P.spa
dc.date.accessioned2020-04-01T14:51:46Z
dc.date.available2020-04-01T14:51:46Z
dc.date.created2016-03
dc.date.issued2016
dc.description.abstractWe used whole-genome sequence typing (WGST) to investigate an outbreak of Sarocladium kiliense bloodstream infections (BSI) associated with receipt of contaminated antinausea medication among oncology patients in Colombia and Chile during 2013-2014. Twenty-five outbreak isolates (18 from patients and 7 from medication vials) and 11 control isolates unrelated to this outbreak were subjected to WGST to elucidate a source of infection. All outbreak isolates were nearly indistinguishable (≤5 single-nucleotide polymorphisms), and >21,000 single-nucleotide polymorphisms were identified from unrelated control isolates, suggesting a point source for this outbreak. S. kiliense has been previously implicated in healthcare-related infections; however, the lack of available typing methods has precluded the ability to substantiate point sources. WGST for outbreak investigation caused by eukaryotic pathogens without reference genomes or existing genotyping methods enables accurate source identification to guide implementation of appropriate control and prevention measures. © 2016, Centers for Disease Control and Prevention (CDC). All rights reserved.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.3201/eid2203.151193
dc.identifier.issn1080-6040
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/21348
dc.language.isoengspa
dc.relation.citationEndPage481
dc.relation.citationIssueNo. 3
dc.relation.citationStartPage476
dc.relation.citationTitleEmerging Infectious Diseases
dc.relation.citationVolumeVol. 22
dc.relation.ispartofEmerging Infectious Diseases, ISSN: 1080-6040 Vol. 22, No. 3 (2016) pp. 476-481spa
dc.relation.urihttps://wwwnc.cdc.gov/eid/article/22/3/pdfs/15-1193.pdfspa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosario
dc.source.reponamereponame:Repositorio Institucional EdocUR
dc.subjectInfección del torrente sanguíneospa
dc.subjectArtículo clínicospa
dc.subjectEstudio controladospa
dc.subjectSecuencia génicaspa
dc.subjectAnálisis del genoma humanospa
dc.subjectFilogenia Infección del torrente sanguíneo de Sarocladium kiliensespa
dc.subjectPolimorfismo de nucleótido simplespa
dc.subject.ddcEvolución & genéticaspa
dc.subject.keywordBloodstream infectionspa
dc.subject.keywordClinical articlespa
dc.subject.keywordControlled studyspa
dc.subject.keywordGene sequencespa
dc.subject.keywordGenome analysisspa
dc.subject.keywordPhylogenyspa
dc.subject.keywordSarocladium kiliense bloodstream infectionspa
dc.subject.keywordSingle nucleotide polymorphismspa
dc.subject.lembTécnicas genéticasspa
dc.subject.lembAgentes infecciososspa
dc.subject.lembMedicamentosspa
dc.subject.lembOncologíasspa
dc.titleWhole-genome sequencing to determine origin of multinational outbreak of Sarocladium kiliense bloodstream infectionsspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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