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The effect of exercise training on mediators of inflammation in breast cancer survivors: A systematic review with meta-analysis

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dc.creatorMeneses-Echávez, Jose Fspa
dc.creatorCorrea-Bautista, Jorge Espa
dc.creatorGonzález-Jiménez, Emiliospa
dc.creatorSchmidt Río-Valle, Jacquelinespa
dc.creatorElkins, Mark Rspa
dc.creatorLobelo, Felipespa
dc.creatorRamírez-Vélez, Robinson
dc.date.accessioned2020-05-26T00:03:51Z
dc.date.available2020-05-26T00:03:51Z
dc.date.created2016spa
dc.description.abstractSeveral sources of evidence indicate that exercise during and after breast cancer could positively modulate the tumor microenvironment. This meta-analysis aimed to determine the effects of exercise training on mediators of inflammation in breast cancer survivors. We searched for randomized controlled trials published from January 1990 to March 2014. An inverse variance method of meta-analysis was performed using a random effects model in the presence of statistical heterogeneity. Eight high-quality trials (n = 478) were included. Exercise improved the serum concentrations of IL6 [weighted mean difference (WMD) = -0.55 pg/mL; 95% confidence interval (CI), -1.02 to -0.09], TNF? (WMD = -0.64 pg/mL; 95%CI, -1.21 to -0.06), IL8(MD= -0.49 pg/mL; 95% CI, -0.89 to -0.09), and IL2 (WMD = 1.03 pg/mL; 95% CI, 0.40 to 1.67). No significant differences were found in the serum concentrations of C-reactive protein (WMD = -0.15; 95% CI, -0.56 to 0.25) or IL10 (WMD = 0.41; 95% CI, -0.18 to 1.02). Exercise training positively modulates chronic low-grade inflammation in women with breast cancer, which may impact upon carcinogenic mechanisms and the tumor microenvironment. These findings align with the other positive effects of exercise for breast cancer survivors, reinforcing the appropriateness of exercise prescription in this population. © 2016 American Association for Cancer Research.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1158/1055-9965.EPI-15-1061
dc.identifier.issn10559965
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/23634
dc.language.isoengspa
dc.publisherAmerican Association for Cancer Research Inc.spa
dc.relation.citationEndPage1017
dc.relation.citationIssueNo. 7
dc.relation.citationStartPage1009
dc.relation.citationTitleCancer Epidemiology Biomarkers and Prevention
dc.relation.citationVolumeVol. 25
dc.relation.ispartofCancer Epidemiology Biomarkers and Prevention, ISSN:10559965, Vol.25, No.7 (2016); pp. 1009-1017spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84977126612&doi=10.1158%2f1055-9965.EPI-15-1061&partnerID=40&md5=bf82def820f4eb893f35872bd94665dbspa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordC reactive proteinspa
dc.subject.keywordHumaneng
dc.subject.keywordInterleukin 2spa
dc.subject.keywordInterleukin 6spa
dc.subject.keywordInterleukin 8spa
dc.subject.keywordTumor necrosis factor alphaspa
dc.subject.keywordAutacoidspa
dc.subject.keywordC reactive proteinspa
dc.subject.keywordIL10 proteineng
dc.subject.keywordIL6 proteineng
dc.subject.keywordInterleukin 10spa
dc.subject.keywordInterleukin 6spa
dc.subject.keywordAerobic exercisespa
dc.subject.keywordBreast cancerspa
dc.subject.keywordBreast carcinogenesisspa
dc.subject.keywordCancer survivorspa
dc.subject.keywordChronic inflammationspa
dc.subject.keywordEvidence based practicespa
dc.subject.keywordExercisespa
dc.subject.keywordHumanspa
dc.subject.keywordInflammationspa
dc.subject.keywordMediator releasespa
dc.subject.keywordMeta analysisspa
dc.subject.keywordPriority journalspa
dc.subject.keywordProtein blood levelspa
dc.subject.keywordRandomized controlled trial (topic)spa
dc.subject.keywordResistance trainingspa
dc.subject.keywordReviewspa
dc.subject.keywordSystematic reviewspa
dc.subject.keywordTai Chispa
dc.subject.keywordTumor microenvironmentspa
dc.subject.keywordYogaspa
dc.subject.keywordBloodspa
dc.subject.keywordBreast tumorspa
dc.subject.keywordCancer survivorspa
dc.subject.keywordEnzyme linked immunosorbent assayspa
dc.subject.keywordExercisespa
dc.subject.keywordFemalespa
dc.subject.keywordKinesiotherapyspa
dc.subject.keywordMiddle agedspa
dc.subject.keywordMortalityspa
dc.subject.keywordPhysiologyspa
dc.subject.keywordProceduresspa
dc.subject.keywordRegression analysisspa
dc.subject.keywordBreast Neoplasmsspa
dc.subject.keywordC-Reactive Proteinspa
dc.subject.keywordCancer Survivorsspa
dc.subject.keywordEnzyme-Linked Immunosorbent Assayspa
dc.subject.keywordExercisespa
dc.subject.keywordExercise Therapyspa
dc.subject.keywordFemalespa
dc.subject.keywordHumansspa
dc.subject.keywordInflammation Mediatorsspa
dc.subject.keywordInterleukin-10spa
dc.subject.keywordInterleukin-6spa
dc.subject.keywordMiddle Agedspa
dc.subject.keywordPhysical Conditioningeng
dc.subject.keywordRandomized Controlled Trials as Topicspa
dc.subject.keywordRegression Analysisspa
dc.titleThe effect of exercise training on mediators of inflammation in breast cancer survivors: A systematic review with meta-analysisspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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