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Visual features in Alzheimer's disease: From basic mechanisms to clinical overview

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dc.creatorCerquera-Jaramillo, María Alejandraspa
dc.creatorNava Mesa, Mauricio Orlandospa
dc.creatorGonzález Reyes, Rodrigo Estebanspa
dc.creatorTellez-Conti, Carlosspa
dc.creatorde-la-Torre, Alejandraspa
dc.date.accessioned2020-05-25T23:57:21Z
dc.date.available2020-05-25T23:57:21Z
dc.date.created2018spa
dc.description.abstractAlzheimer's disease (AD) is the leading cause of dementia worldwide. It compromises patients' daily activities owing to progressive cognitive deterioration, which has elevated direct and indirect costs. Although AD has several risk factors, aging is considered the most important. Unfortunately, clinical diagnosis is usually performed at an advanced disease stage when dementia is established, making implementation of successful therapeutic interventions difficult. Current biomarkers tend to be expensive, insufficient, or invasive, raising the need for novel, improved tools aimed at early disease detection. AD is characterized by brain atrophy due to neuronal and synaptic loss, extracellular amyloid plaques composed of amyloid-beta peptide (A?), and neurofibrillary tangles of hyperphosphorylated tau protein. The visual system and central nervous system share many functional components. Thus, it is plausible that damage induced by A?, tau, and neuroinflammation may be observed in visual components such as the retina, even at an early disease stage. This underscores the importance of implementing ophthalmological examinations, less invasive and expensive than other biomarkers, as useful measures to assess disease progression and severity in individuals with or at risk of AD. Here, we review functional and morphological changes of the retina and visual pathway in AD from pathophysiological and clinical perspectives. Copyright © 2018 María Alejandra Cerquera-Jaramillo et al.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1155/2018/2941783
dc.identifier.issn16875443
dc.identifier.issn20905904
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/22648
dc.language.isoengspa
dc.publisherHindawi Limitedspa
dc.relation.citationTitleNeural Plasticity
dc.relation.citationVolumeVol. 2018
dc.relation.ispartofNeural Plasticity, ISSN:16875443, 20905904, Vol.2018,(2018)spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85056280444&doi=10.1155%2f2018%2f2941783&partnerID=40&md5=a440128fc58cfa27672e28065d25be86spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordAmyloid beta proteinspa
dc.subject.keywordhumaneng
dc.subject.keywordApolipoprotein espa
dc.subject.keywordamyloideng
dc.subject.keywordTau proteinspa
dc.subject.keywordAmyloid precursor proteinspa
dc.subject.keywordApp proteineng
dc.subject.keywordTau proteinspa
dc.subject.keywordAge related macular degenerationspa
dc.subject.keywordAgingspa
dc.subject.keywordAlzheimer diseasespa
dc.subject.keywordBrain cortexspa
dc.subject.keywordBrain electrophysiologyspa
dc.subject.keywordBrain regionspa
dc.subject.keywordBrain stemspa
dc.subject.keywordCentral nervous systemspa
dc.subject.keywordChoroidspa
dc.subject.keywordClinical featurespa
dc.subject.keywordEye toxicityspa
dc.subject.keywordHumanspa
dc.subject.keywordMild cognitive impairmentspa
dc.subject.keywordNeuropathologyspa
dc.subject.keywordNeurophysiologyspa
dc.subject.keywordNonhumanspa
dc.subject.keywordOptic nervespa
dc.subject.keywordOptical coherence tomographyspa
dc.subject.keywordPathophysiologyspa
dc.subject.keywordRetinaspa
dc.subject.keywordRetina blood vesselspa
dc.subject.keywordRetina macula luteaspa
dc.subject.keywordReviewspa
dc.subject.keywordSubcortexspa
dc.subject.keywordVisual impairmentspa
dc.subject.keywordVisual system functionspa
dc.subject.keywordAlzheimer diseasespa
dc.subject.keywordAmyloid plaquespa
dc.subject.keywordDisease exacerbationspa
dc.subject.keywordMetabolismspa
dc.subject.keywordPathophysiologyspa
dc.subject.keywordVisual disorderspa
dc.subject.keywordVisual systemspa
dc.subject.keywordAlzheimer diseasespa
dc.subject.keywordAmyloid beta-protein precursorspa
dc.subject.keywordDisease progressionspa
dc.subject.keywordHumansspa
dc.subject.keywordPlaqueeng
dc.subject.keywordRetinaspa
dc.subject.keywordTau proteinsspa
dc.subject.keywordVision disordersspa
dc.subject.keywordVisual pathwaysspa
dc.titleVisual features in Alzheimer's disease: From basic mechanisms to clinical overviewspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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