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Influence of methotrexate on the frequency of postoperative infectious complications in patients with rheumatoid arthritis

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dc.creatorAnaya, Juan-Manuelspa
dc.creatorSany, J.spa
dc.creatorCanovas, F.spa
dc.creatorCombe, Bspa
dc.creatorJorgensen, C.spa
dc.creatorSaker, Sspa
dc.date.accessioned2020-08-19T14:44:20Z
dc.date.available2020-08-19T14:44:20Z
dc.date.created1993spa
dc.description.abstractOBJECTIVE: To evaluate the influence of methotrexate (MTX) on the frequency of postoperative complications in patients with rheumatoid arthritis (RA). METHODS: We conducted a randomized unblinded prospective study in 64 patients with RA treated with MTX and who underwent orthopedic surgery. Two groups of patients were constituted: in Group A (32 patients), MTX was interrupted 7 days before the surgery; in Group B (32 patients), MTX was not discontinued. RESULTS: Fifty surgical procedures were performed in Group A and 39 procedures in Group B. No postoperative infection was observed in any group. A prolonged wound healing was noticed in 6 cases in Group A and in 4 cases in Group B (not significant). CONCLUSION: We suggest that the interruption of MTX is not required in patients with RA when an orthopedic surgical treatment is planned. However a large prospective study is needed to make a definitive conclusion.eng
dc.format.mimetypeapplication/pdf
dc.identifier.issnISSN: 0315-162X
dc.identifier.issnEISSN: 1499-2752
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/27868
dc.language.isoengspa
dc.publisherEurope PMCspa
dc.relation.citationEndPage1132
dc.relation.citationIssueNo. 7
dc.relation.citationStartPage1129
dc.relation.citationTitleJournal of Rheumatology
dc.relation.citationVolumeVol. 20
dc.relation.ispartofJournal of Rheumatology, ISSN: 0315-162X;EISSN: 1499-2752, Vol.20, No.7 (30 June 1993); pp.1129-1132spa
dc.relation.urihttps://europepmc.org/article/med/8371204spa
dc.rights.accesRightsinfo:eu-repo/semantics/closedAccess
dc.rights.accesoBloqueado (Texto referencial)spa
dc.sourceJournal of Rheumatologyspa
dc.source.instnameinstname:Universidad del Rosario
dc.source.reponamereponame:Repositorio Institucional EdocUR
dc.subject.keywordInfluence of methotrexate (MTX)spa
dc.subject.keywordRheumatoid arthritisspa
dc.titleInfluence of methotrexate on the frequency of postoperative infectious complications in patients with rheumatoid arthritisspa
dc.title.TranslatedTitleInfluencia del metotrexato en la frecuencia de complicaciones infecciosas posoperatorias en pacientes con artritis reumatoidespa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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