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Macrophage migration inhibitory factor gene influences the risk of developing tuberculosis in northwestern Colombian population

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dc.creatorGómez, L. M.spa
dc.creatorSánchez, E.spa
dc.creatorRuiz?Narvaez, E. A.spa
dc.creatorLópez?Nevot, M. A.spa
dc.creatorAnaya, Juan-Manuelspa
dc.creatorMartín, J.spa
dc.date.accessioned2020-05-26T00:01:36Z
dc.date.available2020-05-26T00:01:36Z
dc.date.created2007spa
dc.description.abstractMacrophage migration inhibitory factor (MIF) is a pleiotropic cytokine that regulates innate and adaptative immunity responses against pathogens. The MIF gene, at 22q11.2, is polymorphic. Functional promoter variants in the MIF gene influence susceptibility to inflammatory diseases in Caucasians and Africans. An association study was carried out to examine the influence of MIF -173 single nucleotide polymorphism and the MIF -794 microsatellite on the susceptibility to develop human tuberculosis (TB) in a well-defined Latin-American population. To this purpose, 230 northwestern Colombian patients with pulmonary TB, negative for human immunodeficiency virus infection, and 235 matched healthy individuals stratified by the tuberculin skin test were examined. Multivariate analysis showed that MIF -173C allele was associated with disease (odds ratio = 1.64, 95% confidence interval 1.07-2.52) in a dominant pattern. No allele in the MIF -794 CATT microsatellite was associated with risk of TB. These results indicate that MIF gene influences the risk of developing TB in the studied population. © 2007 Blackwell Munksgaard.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1111/j.1399-0039.2007.00843.x
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/23386
dc.language.isoengspa
dc.relation.citationEndPage33
dc.relation.citationIssueNo. 1
dc.relation.citationStartPage28
dc.relation.citationTitleTissue Antigens
dc.relation.citationVolumeVol. 70
dc.relation.ispartofTissue Antigens, Vol.70, No.1 (2007); pp. 28-33spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-34249999778&doi=10.1111%2fj.1399-0039.2007.00843.x&partnerID=40&md5=19e1abaf5bf233a05a69989514403942spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordMacrophage migration inhibition factorspa
dc.subject.keywordhumaneng
dc.subject.keywordsingle nucleotideeng
dc.subject.keywordAdultspa
dc.subject.keywordpulmonaryeng
dc.subject.keywordpair 22eng
dc.subject.keywordArticlespa
dc.subject.keywordColombiaspa
dc.subject.keywordControlled studyspa
dc.subject.keywordFemalespa
dc.subject.keywordGenetic associationspa
dc.subject.keywordGenetic riskspa
dc.subject.keywordHumanspa
dc.subject.keywordHuman immunodeficiency virus infectionspa
dc.subject.keywordInfection riskspa
dc.subject.keywordLung tuberculosisspa
dc.subject.keywordMajor clinical studyspa
dc.subject.keywordMalespa
dc.subject.keywordMicrosatellite markerspa
dc.subject.keywordMultivariate analysisspa
dc.subject.keywordPriority journalspa
dc.subject.keywordSingle nucleotide polymorphismspa
dc.subject.keywordTuberculin testspa
dc.subject.keywordAllelesspa
dc.subject.keywordCase-control studiesspa
dc.subject.keywordChromosomeseng
dc.subject.keywordColombiaspa
dc.subject.keywordConfidence intervalsspa
dc.subject.keywordFemalespa
dc.subject.keywordGenetic predisposition to diseasespa
dc.subject.keywordGeographyspa
dc.subject.keywordHumansspa
dc.subject.keywordMacrophage migration-inhibitory factorsspa
dc.subject.keywordMalespa
dc.subject.keywordMicrosatellite repeatsspa
dc.subject.keywordOdds ratiospa
dc.subject.keywordPolymorphismeng
dc.subject.keywordPopulation groupsspa
dc.subject.keywordRisk factorsspa
dc.subject.keywordTuberculin testspa
dc.subject.keywordTuberculosiseng
dc.subject.keywordHuman immunodeficiency virusspa
dc.subject.keywordDelayed-type hypersensitivityspa
dc.subject.keywordMicrosatellitespa
dc.subject.keywordMifspa
dc.subject.keywordPolymorphismspa
dc.subject.keywordSingle nucleotide polymorphismspa
dc.subject.keywordTuberculin skin testspa
dc.subject.keywordTuberculosisspa
dc.titleMacrophage migration inhibitory factor gene influences the risk of developing tuberculosis in northwestern Colombian populationspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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