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Designing and optimizing new antimicrobial peptides: all targets are not the same

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dc.creatorBarreto-Santamaría A.spa
dc.creatorPatarroyo M.E.spa
dc.creatorCurtidor H.spa
dc.date.accessioned2020-05-26T00:05:20Z
dc.date.available2020-05-26T00:05:20Z
dc.date.created2019spa
dc.description.abstractBecause the resistance of microorganisms to the available antibiotics is a growing healthcare problem worldwide, the search for new antimicrobial peptides (AMPs) that provide useful therapeutic options has been increasing in importance. Many initial candidates have had to be discarded after having advanced to the preclinical and clinical stages. This has led to substantial losses in terms of time and money. For that reason, the essential characteristics of AMPs (i.e. their activity, selectivity, stability in physiological conditions and low production cost) must be considered in their design. In addition, peptides could be active against several kinds of cells with activity and selectivity resulting from interaction with multiple target cell components, which sometimes are present in mammalian cells as well. Thus, the cellular composition is important in the AMP-target cell interaction and must be considered in the design of AMPs, too. This review describes general aspects of AMP design, limitations concerning their therapeutic application, and optimization strategies for overcoming such limitations. © 2019, © 2019 Informa UK Limited, trading as Taylor and Francis Group.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1080/10408363.2019.1631249
dc.identifier.issn10408363
dc.identifier.issn1549781X
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/23781
dc.language.isoengspa
dc.publisherTaylor and Francis Ltdspa
dc.relation.citationEndPage373
dc.relation.citationIssueNo. 6
dc.relation.citationStartPage351
dc.relation.citationTitleCritical Reviews in Clinical Laboratory Sciences
dc.relation.citationVolumeVol. 56
dc.relation.ispartofCritical Reviews in Clinical Laboratory Sciences, ISSN:10408363, 1549781X, Vol.56, No.6 (2019); pp. 351-373spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85070523024&doi=10.1080%2f10408363.2019.1631249&partnerID=40&md5=133160fd7b211c0acc3384c1e0f1ba0aspa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordAntifungal agentspa
dc.subject.keywordAntiinflammatory agentspa
dc.subject.keywordAntineoplastic agentspa
dc.subject.keywordAntiparasitic agentspa
dc.subject.keywordAntivirus agentspa
dc.subject.keywordPolypeptide antibiotic agentspa
dc.subject.keywordAmino acid compositionspa
dc.subject.keywordAmino acid sequencespa
dc.subject.keywordAntibacterial activityspa
dc.subject.keywordAntibiofilm activityspa
dc.subject.keywordAntibiotic resistancespa
dc.subject.keywordAntifungal activityspa
dc.subject.keywordAntiinflammatory activityspa
dc.subject.keywordAntimicrobial activityspa
dc.subject.keywordAntineoplastic activityspa
dc.subject.keywordAntiparasitic activityspa
dc.subject.keywordAntiviral activityspa
dc.subject.keywordBacterial membranespa
dc.subject.keywordDrug costspa
dc.subject.keywordDrug designspa
dc.subject.keywordDrug selectivityspa
dc.subject.keywordDrug stabilityspa
dc.subject.keywordHumanspa
dc.subject.keywordHydrophobicityspa
dc.subject.keywordNonhumanspa
dc.subject.keywordPriority journalspa
dc.subject.keywordProtein structurespa
dc.subject.keywordReviewspa
dc.subject.keywordSaccharomyces cerevisiaespa
dc.subject.keywordStatic electricityspa
dc.subject.keywordStructure activity relationspa
dc.subject.keywordAntimicrobial activityspa
dc.subject.keywordAntimicrobial peptidesspa
dc.subject.keywordHemolytic activityspa
dc.subject.keywordMinimum inhibitory concentration (mic)spa
dc.subject.keywordSar studyspa
dc.subject.keywordSelectivityspa
dc.titleDesigning and optimizing new antimicrobial peptides: all targets are not the samespa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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