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Incidence, duration, and reappearance of type-specific cervical human papillomavirus infections in young women

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dc.creatorInsinga, Ralph P.spa
dc.creatorPerez, Gonzalospa
dc.creatorWheeler, Cosette M.spa
dc.creatorKoutsky, Laura A.spa
dc.creatorGarland, Suzanne M.spa
dc.creatorLeodolter, Seppspa
dc.creatorJoura, Elmar A.spa
dc.creatorFerris, Daron G.spa
dc.creatorSteben, Marcspa
dc.creatorBrown, Darron R.spa
dc.creatorElbasha, Elamin H.spa
dc.creatorPaavonen, Jormaspa
dc.creatorHaupt, Richard M.spa
dc.date.accessioned2020-05-26T00:03:48Z
dc.date.available2020-05-26T00:03:48Z
dc.date.created2010spa
dc.description.abstractBackground: We describe the incidence and duration of cervical human papillomavirus (HPV) infection episodes along with the risk of infection reappearance following a period of nondetection. Methods:Women (1,788) ages 16 to 23 years underwent cytologic testing and PCR-based testing of cervical swab samples for HPV DNA (HPV-16/18/31/33/35/45/52/58/59) at ?6-month intervals for up to 4 years in the context of a phase 3 clinical trial (placebo arm). HPV type - specific incidence rates were estimated per 100 person-years. Duration of type-specific cervical infection episodes and risk of reappearance following a period of nondetection were estimated using Kaplan-Meier methods. Results: HPV-16 exhibited the highest (5.9), and HPV-35 and HPV-33 exhibited the lowest (1.0) incidence rates per 100 person-years. Mean cervical infection durations ranged from 13 months for HPV-59 to 20 months for HPV-16 and 58 (with ongoing infections censored at the time of treatment, if done). The risk of cervical infection reappearance within ?3 years following a period of nondetection ranged from 0% to 16% across HPV types, with a mean of 8%. Limited evidence was found for a role of false-positive HPV tests, missed infections that were above the threshold for detection, or new acquisition of infection in accounting for patterns of infection reappearance. Conclusions: Incidence of high-risk cervical infection was observed to vary considerably more across HPV types than infection duration. A nontrivial proportion of women exhibited infection reappearance following a period of nondetection, with a potential explanation for many such events observed within this analysis being a return to detectable levels of a previously acquired infection. Impact: The risk of HPV infection reappearance following a period of nondetection has not been previously reported for individual HPV types, and this study finds that a nontrivial proportion of infected women exhibit reappearances. Future studies could ascertain subject-level factors that potentially modify the risk of infection reappearance. ©2010 AACR.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1158/1055-9965.EPI-09-1235
dc.identifier.issn10559965
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/23631
dc.language.isoengspa
dc.publisherAmerican Association for Cancer Research Inc.spa
dc.relation.citationEndPage1594
dc.relation.citationIssueNo. 6
dc.relation.citationStartPage1585
dc.relation.citationTitleCancer Epidemiology Biomarkers and Prevention
dc.relation.citationVolumeVol. 19
dc.relation.ispartofCancer Epidemiology Biomarkers and Prevention, ISSN:10559965, Vol.19, No.6 (2010); pp. 1585-1594spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-77953297415&doi=10.1158%2f1055-9965.EPI-09-1235&partnerID=40&md5=c4ff1e71c6f202e566a47b5eee621114spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordAdolescentspa
dc.subject.keywordphase iii as topiceng
dc.subject.keywordArticlespa
dc.subject.keywordClinical featurespa
dc.subject.keywordClinical trialspa
dc.subject.keywordControlled studyspa
dc.subject.keywordCytologyspa
dc.subject.keywordDisease classificationspa
dc.subject.keywordDisease durationspa
dc.subject.keywordFemalespa
dc.subject.keywordHumanspa
dc.subject.keywordHuman tissuespa
dc.subject.keywordIncidencespa
dc.subject.keywordMajor clinical studyspa
dc.subject.keywordPapillomavirus infectionspa
dc.subject.keywordPolymerase chain reactionspa
dc.subject.keywordPriority journalspa
dc.subject.keywordUterine cervixspa
dc.subject.keywordDouble blind procedurespa
dc.subject.keywordGeneticsspa
dc.subject.keywordIsolation and purificationspa
dc.subject.keywordPapilloma virusspa
dc.subject.keywordPapillomavirus infectionsspa
dc.subject.keywordPhase 3 clinical trial (topic)spa
dc.subject.keywordPrevalencespa
dc.subject.keywordRandomized controlled trial (topic)spa
dc.subject.keywordUterine cervical diseasesspa
dc.subject.keywordVirologyspa
dc.subject.keywordYoung adultspa
dc.subject.keywordVirus dnaspa
dc.subject.keywordAdolescentspa
dc.subject.keywordClinical trialseng
dc.subject.keywordDnaeng
dc.subject.keywordDouble-blind methodspa
dc.subject.keywordFemalespa
dc.subject.keywordHumansspa
dc.subject.keywordIncidencespa
dc.subject.keywordPapillomaviridaespa
dc.subject.keywordPapillomavirus infectionsspa
dc.subject.keywordPolymerase chain reactionspa
dc.subject.keywordPrevalencespa
dc.subject.keywordRandomized controlled trials as topicspa
dc.subject.keywordUterine cervical diseasesspa
dc.subject.keywordYoung adultspa
dc.titleIncidence, duration, and reappearance of type-specific cervical human papillomavirus infections in young womenspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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