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Association between circulating adipocytokine concentrations and microvascular complications in patients with type 2 diabetes mellitus: a systematic review and meta-analysis of controlled cross-sectional studies

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dc.creatorRodrígueza, Alexander J.spa
dc.creatordos Santos Nunes, Vaniaspa
dc.creatorMastronardia, Claudio A.spa
dc.creatorNeeman, Teresaspa
dc.creatorPaz-Filho, Gilberto J.spa
dc.date.accessioned2020-08-06T16:20:37Z
dc.date.available2020-08-06T16:20:37Z
dc.date.created2016-03spa
dc.description.abstractBackground The adipocytokines leptin and adiponectin have been variously associated with diabetic microvascular complications. No comprehensive clinical data exist examining the association between adipocytokines and the presence of these complications. Methods This is a systematic review of cross-sectional studies comparing circulating adipocytokines in patients with type 2 diabetes mellitus (T2DM), with and without microvascular complications. Studies were retrieved from MEDLINE, EMBASE, Scopus and Cochrane databases. Study quality was evaluated using a modified Newcastle–Ottawa Scale. Meta-analysis was performed using an inverse-variance model, providing standardised mean differences (SMD) and 95% confidence intervals (CI). Heterogeneity was determined by I2 statistic. Results Amongst 554 identified studies, 28 were included in the review. Study quality range was 3.5–9 (maximum 11). Higher leptin levels were associated with microalbuminuria (SMD = 0.41; 95% CI = 0.14–0.67; n = 901; p = 0.0003), macroalbuminuria (SMD = 0.68; 95% CI = 0.30–1.06; n = 406; p = 0.0004), and neuropathy (SMD = 0.26; 95% CI = 0.07–0.44; n = 609; p = 0.008). Higher adiponectin levels were associated with microalbuminuria (SMD = 0.55; 95% CI = 0.29–0.81, n = 274; p < 0.001), macroalbuminuria (SMD = 1.37; 95% CI = 0.78–1.97, n = 246; p < 0.00001), neuropathy (SMD = 0.25; 95% CI = 0.14–0.36; n = 1516; p < 0.00001), and retinopathy (SMD = 0.38; 95% CI = 0.25–0.51; n = 1306; p < 0.00001). Meta-regression suggested no influence of body mass index and duration of diabetes on effect size, and a weak trend in terms of age on effect size. Discussion Our meta-analysis suggests leptin and adiponectin levels are higher in T2DM patients with microvascular complications. Studies were limited by cross-sectional design. Large prospective analyses are required to validate these findings.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1016/j.jdiacomp.2015.11.004
dc.identifier.issnISSN: 1056-8727
dc.identifier.issnEISSN: 0891-6632
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/26081
dc.language.isoengspa
dc.publisherElsevierspa
dc.relation.citationEndPage367
dc.relation.citationIssueNo. 2
dc.relation.citationStartPage357
dc.relation.citationTitleJournal of Diabetes and its Complications
dc.relation.citationVolumeVol. 30
dc.relation.ispartofJournal of Diabetes and its Complications, ISSN: 1056-8727;EISSN: 0891-6632 Vol.30, No.2 (2016); pp.357-367spa
dc.relation.urihttps://www.sciencedirect.com/science/article/pii/S1056872715004419spa
dc.rights.accesRightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.accesoRestringido (Acceso a grupos específicos)spa
dc.sourceJournal of Diabetes and its Complicationsspa
dc.source.instnameinstname:Universidad del Rosario
dc.source.reponamereponame:Repositorio Institucional EdocUR
dc.subject.keywordAdipocytokinesspa
dc.subject.keywordAdiponectinspa
dc.subject.keywordDiabetesspa
dc.subject.keywordLeptinspa
dc.subject.keywordNephropathyspa
dc.subject.keywordNeuropathyspa
dc.subject.keywordRetinopathyspa
dc.titleAssociation between circulating adipocytokine concentrations and microvascular complications in patients with type 2 diabetes mellitus: a systematic review and meta-analysis of controlled cross-sectional studiesspa
dc.title.TranslatedTitleAsociación entre las concentraciones circulantes de adipocitoquinas y las complicaciones microvasculares en pacientes con diabetes mellitus tipo 2: una revisión sistemática y un metanálisis de estudios transversales controladosspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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