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Specific erythrocyte binding capacity and biological activity of plasmodium falciparum-derived rhoptry-associated protein 1 peptides

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dc.creatorCurtidor, Hernandospa
dc.creatorOcampo, Marisol
dc.creatorTovar, Dianaspa
dc.creatorLópez, Ramsesspa
dc.creatorGarc??a, Javierspa
dc.creatorValbuena, Jhonspa
dc.creatorVera, Ricardospa
dc.creatorSuárez, Jorgespa
dc.creatorRodr??guez, Luis E.spa
dc.creatorPuentes, Álvarospa
dc.creatorGuzmán, Fannyspa
dc.creatorTorres, Elizabethspa
dc.creatorPatarroyo, Manuel E.spa
dc.date.accessioned2020-08-19T14:40:41Z
dc.date.available2020-08-19T14:40:41Z
dc.date.created2004-02-25spa
dc.description.abstractRhoptry-associated protein 1 (RAP1) is a merozoite antigen within Plasmodium falciparum rhoptries as yet having no specific function described for it. Synthetic peptides spanning the RAP1 sequence were tested in erythrocyte binding assays to identify possible RAP1 functional regions. Five high activity binding peptides (HABPs) were identified; 26201, 26202, 26203 and 26204 spanned residues –K540 within RAP1 Cys region, whilst 26188 (–Y220) was located in p67 amino terminal. The results showed that peptide binding was saturable, some HABPs inhibited in vitro merozoite invasion and specifically bound to a 72 kDa protein in red blood cell membrane. HABP possible function in merozoite invasion of erythrocytes is also discussed.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1016/j.vaccine.2003.07.019
dc.identifier.issnISSN: 0264-410X
dc.identifier.issnEISSN: 1873-2518
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/26988
dc.language.isoengspa
dc.publisherThe Japanese Society for Vaccinologyspa
dc.publisherElsevierspa
dc.relation.citationEndPage1062
dc.relation.citationIssueNo. 8
dc.relation.citationStartPage1054
dc.relation.citationTitleVaccine
dc.relation.citationVolumeVol. 22
dc.relation.ispartofVaccine, ISSN: 0264-410X;EISSN: 1873-2518, Vol.22, No.8 (2004); pp. 1054-1062 spa
dc.relation.urihttps://www.sciencedirect.com/science/article/pii/S0264410X03006625?via%3Dihubspa
dc.rights.accesRightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.accesoRestringido (Acceso a grupos específicos)spa
dc.sourceVaccinespa
dc.source.instnameinstname:Universidad del Rosario
dc.source.reponamereponame:Repositorio Institucional EdocUR
dc.subject.keywordRAP1spa
dc.subject.keywordPeptidesspa
dc.subject.keywordMalariaspa
dc.titleSpecific erythrocyte binding capacity and biological activity of plasmodium falciparum-derived rhoptry-associated protein 1 peptidesspa
dc.title.TranslatedTitleCapacidad de unión de eritrocitos específica y actividad biológica de péptidos de proteína 1 asociados a rhoptry derivados de Plasmodium falciparumspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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