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Actividad de beta-galactosidasa como marcador de senescencia en cultivos primarios del epitelio de la superficie ovárica

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dc.creatorChuaire-Noack, Lilianspa
dc.creatorRondon-Lagos, Sandraspa
dc.creatorSanchez-Corredor, Magda-Carolina
dc.creatorIbáñez Pinilla, Milcíades
dc.creatorRamírez Clavijo, Sandra Rocío
dc.date.accessioned2020-06-11T13:21:06Z
dc.date.available2020-06-11T13:21:06Z
dc.date.created2010spa
dc.description.abstractbeta-galaetosidase activity reflects the rate of cellular aging in vitro. Such activity was quantified at pH 6 in ovarian epithelial cells from 28 donors without a history of cancer, by the chemoluminiscent method. The cells were serially cultured until they achieved the state of permanent growth arrest. During the exponential growth phase, all cultures showed a similar pattern of growth and low beta-galitetosidase activity. However, both in the onset of decrease replicative activity, as well as in the onset of the stationary phase, there was a significant rise in the enzyme activity. Our results showed that P-galactosidase activity can be considered as a replicative senescence marker of the ovarian surface epithelium at pH 6.spa
dc.format.mimetypeapplication/pdf
dc.identifier.issn0535-5133
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/24728
dc.language.isospa
dc.publisherUniversidad del Zuliaspa
dc.relation.citationEndPage367
dc.relation.citationIssueNo. 3
dc.relation.citationStartPage351
dc.relation.citationTitleINVESTIGACION CLINICA
dc.relation.citationVolumeVol. 51
dc.relation.ispartofINVESTIGACION CLINICA, ISSN:0535-5133, Vol.51, No.3 (2010); pp. 351-367spa
dc.rights.accesRightsinfo:eu-repo/semantics/closedAccess
dc.rights.accesoBloqueado (Texto referencial)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subjectbeta-galactosidasaspa
dc.subjectsenescencia replicativaspa
dc.subjectbiomarcadorspa
dc.subjectcélulas epiteliales de ovariospa
dc.subjectSenescencia celularspa
dc.subjectSenescencia replicativaspa
dc.subjectCélulasspa
dc.subjectCáncerspa
dc.subjectBiomarcadorspa
dc.subjectSupresiónspa
dc.subjectIncrementarspa
dc.subjectBiologíaspa
dc.subjectAñosspa
dc.subject.keywordbeta-galactosidasespa
dc.subject.keywordreplicative senescencespa
dc.subject.keywordbiomarkerspa
dc.subject.keywordovarian epithelial cellsspa
dc.subject.keywordCellular senescencespa
dc.subject.keywordReplicative senescencespa
dc.subject.keywordCellsspa
dc.subject.keywordCancerspa
dc.subject.keywordBiomarkerspa
dc.subject.keywordSuppressionspa
dc.subject.keywordIncreasespa
dc.subject.keywordBiologyspa
dc.subject.keywordAgespa
dc.titleActividad de beta-galactosidasa como marcador de senescencia en cultivos primarios del epitelio de la superficie ováricaspa
dc.title.TranslatedTitlebeta-Galactosidase activity as a marker of senescence in primary cultures of the ovarian surface epitheliumeng
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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