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Low genetic diversity in the locus encoding the Plasmodium vivax P41 protein in Colombia's parasite population

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dc.creatorForero Rodríguez, Johanna
dc.creatorGarzón-Ospina, Diego
dc.creatorPatarroyo, Manuel A.
dc.creator.googleForero-Rodríguez, Johannaspa
dc.creator.googleGarzón-Ospina, Diegospa
dc.creator.googlePatarroyo, Manuel A.spa
dc.date.accessioned2020-04-23T14:01:32Z
dc.date.available2020-04-23T14:01:32Z
dc.date.created2014
dc.date.issued2014
dc.description.abstractBackground: The development of malaria vaccine has been hindered by the allele-specific responses produced by some parasite antigens' high genetic diversity. Such antigen genetic diversity must thus be evaluated when designing a completely effective vaccine. Plasmodium falciparum P12, P38 and P41 proteins have red blood cell binding regions in the s48/45 domains and are located on merozoite surface, P41 forming a heteroduplex with P12. These three genes have been identified in Plasmodium vivax and share similar characteristics with their orthologues in Plasmodium falciparum. Plasmodium vivax pv12 and pv38 have low genetic diversity but pv41 polymorphism has not been described.Results: Similarly to other members of the 6-Cys family, pv41 had low genetic polymorphism. pv41 3′-end displayed the highest nucleotide diversity value; several substitutions found there were under positive selection. Negatively selected codons at inter-species level were identified in the s48/45 domains; p41 would thus seem to have functional/structural constraints due to the presence of these domains.Methods. The present study was aimed at evaluating the P. vivax p41 (pv41) gene's polymorphism. DNA sequences from Colombian clinical isolates from pv41 gene were analysed for characterising and studying the genetic diversity and the evolutionary forces that produced the variation pattern so observed.Conclusions: In spite of the functional constraints of Pv41 s48/45 domains, immune system pressure seems to have allowed non-synonymous substitutions to become fixed within them as an adaptation mechanism; including Pv41 s48/45 domains in a vaccine should thus be carefully evaluated due to these domains containing some allele variants. © 2014Forero-Rodríguez et al.; licensee BioMed Central Ltd.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1186/1475-2875-13-388
dc.identifier.issn1475-2875
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/21745
dc.language.isoengspa
dc.relation.citationIssueNo. 1
dc.relation.citationTitleMalaria Journal
dc.relation.citationVolumeVol. 13
dc.relation.ispartofMalaria Journal, ISSN: 1475-2875 Vol. 13, No. 1 (2014)spa
dc.relation.urihttps://malariajournal.biomedcentral.com/track/pdf/10.1186/1475-2875-13-388spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosario
dc.source.reponamereponame:Repositorio Institucional EdocUR
dc.subjectPlasmodium vivaxspa
dc.subject.ddcEnfermedadesspa
dc.subject.keywordPlasmodium vivaxspa
dc.subject.keyword6-Cysspa
dc.subject.keywordpv41spa
dc.subject.keywords48/45 domainsspa
dc.subject.keywordGenetic variabilityspa
dc.subject.lembMalariaspa
dc.subject.lembPlasmodium vivaxspa
dc.titleLow genetic diversity in the locus encoding the Plasmodium vivax P41 protein in Colombia's parasite populationspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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