Ítem
Solo Metadatos

Comparative study of the biological properties of Trypanosoma cruzi I genotypes in a murine experimental model

Mostrar el registro sencillo de la publicación
dc.creatorCruz, Lissaspa
dc.creatorVivas, Angiespa
dc.creatorMontilla, Marlenyspa
dc.creatorGalindo Hernández, Carolinaspa
dc.creatorFlórez, Carolinaspa
dc.creatorParra, Edgarspa
dc.creatorRamírez, Juan David
dc.date.accessioned2020-05-26T00:11:19Z
dc.date.available2020-05-26T00:11:19Z
dc.date.created2015spa
dc.description.abstractChagas disease is an endemic zoonosis in Latin America and caused by the parasite Trypanosoma cruzi. This kinetoplastid displays remarkable genetic variability, allowing its classification into six Discrete Typing Units (DTUs) from TcI to TcVI. T. cruzi I presents the broadest geographical distribution in the continent and has been associated to severe forms of cardiomyopathies. Recently, a particular genotype associated to human infections has been reported and named as TcIDOM (previously named TcIa-b). This genotype shows to be clonal and adapted to the domestic cycle but so far no studies have determined the biological properties of domestic (TcIDOM) and sylvatic TcI strains (previously named TcIc-e). Hence, the aim of this study was to untangle the biological features of these genotypes in murine models. We infected ICR-CD1 mice with five TcI strains (two domestic, two sylvatic and one natural mixture) and determined the course of infection during 91days (acute and chronic phase of the disease) in terms of parasitemia, tissue tropism, immune response (IgG titers) and tissue invasion by means of histopathology studies. Statistically significant differences were observed in terms of parasitemia curves and prepatent period between domestic (TcIDOM) and sylvatic strains. There were no differences in terms of IgG antibodies response across the mice infected with the five strains. Regarding the histopathology, our results indicate that domestic strains present higher parasitemias and low levels of histopathological damage. In contrast, sylvatic strains showed lower parasitemias and high levels of histopathological damage. These results highlight the sympatric and behavioral differences of domestic and sylvatic TcI strains; the clinical and epidemiological implications are herein discussed. © 2014 Elsevier B.V.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1016/j.meegid.2014.11.012
dc.identifier.issn15671348
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/24295
dc.language.isoengspa
dc.publisherElsevierspa
dc.relation.citationEndPage117
dc.relation.citationStartPage110
dc.relation.citationTitleInfection, Genetics and Evolution
dc.relation.citationVolumeVol. 29
dc.relation.ispartofInfection, Genetics and Evolution, ISSN:15671348, Vol.29,(2015); pp. 110-117spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84912002726&doi=10.1016%2fj.meegid.2014.11.012&partnerID=40&md5=bbd9f6b06f12fe3cad3f8e2da601ff9espa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordImmunoglobulin Gspa
dc.subject.keywordAnimal modelspa
dc.subject.keywordProtozoaneng
dc.subject.keywordAntibody titerspa
dc.subject.keywordAntigenicityspa
dc.subject.keywordArticlespa
dc.subject.keywordBody weightspa
dc.subject.keywordChagas diseasespa
dc.subject.keywordComparative studyspa
dc.subject.keywordControlled studyspa
dc.subject.keywordEpidemiological monitoringspa
dc.subject.keywordExonspa
dc.subject.keywordGene sequencespa
dc.subject.keywordGenetic variabilityspa
dc.subject.keywordGenotypespa
dc.subject.keywordHistopathologyspa
dc.subject.keywordImmune responsespa
dc.subject.keywordImmunofluorescence testspa
dc.subject.keywordInfectionspa
dc.subject.keywordKinetoplastidaspa
dc.subject.keywordMolecular epidemiologyspa
dc.subject.keywordMortalityspa
dc.subject.keywordMousespa
dc.subject.keywordNonhumanspa
dc.subject.keywordParasitemiaspa
dc.subject.keywordProtozoal geneticsspa
dc.subject.keywordQualitative analysisspa
dc.subject.keywordQuantitative analysisspa
dc.subject.keywordReal time polymerase chain reactionspa
dc.subject.keywordTrypanosoma cruzispa
dc.subject.keywordAnimalsspa
dc.subject.keywordChagas diseasespa
dc.subject.keywordClassificationspa
dc.subject.keywordGeneticsspa
dc.subject.keywordGenomeeng
dc.subject.keywordGenotypespa
dc.subject.keywordGrowth and developmentspa
dc.subject.keywordHeartspa
dc.subject.keywordHumansspa
dc.subject.keywordImmunologyspa
dc.subject.keywordMalespa
dc.subject.keywordMicespa
dc.subject.keywordMice, Inbred ICRspa
dc.subject.keywordMolecular Typingspa
dc.subject.keywordParasitemiaspa
dc.subject.keywordParasitologyspa
dc.subject.keywordPathologyspa
dc.subject.keywordTropismspa
dc.subject.keywordTrypanosoma cruzispa
dc.subject.keywordMurinaespa
dc.subject.keywordTrypanosoma cruzispa
dc.subject.keywordAnimalsspa
dc.subject.keywordChagas Diseasespa
dc.subject.keywordDisease Models, Animalspa
dc.subject.keywordGenotypespa
dc.subject.keywordHeartspa
dc.subject.keywordHumansspa
dc.subject.keywordMalespa
dc.subject.keywordMicespa
dc.subject.keywordMolecular Typingspa
dc.subject.keywordParasitemiaspa
dc.subject.keywordTropismspa
dc.subject.keywordTrypanosoma cruzispa
dc.subject.keywordChagas diseasespa
dc.subject.keywordDTUspa
dc.subject.keywordEpidemiological cyclesspa
dc.subject.keywordMolecular epidemiologyspa
dc.subject.keywordTrypanosoma cruzi Ispa
dc.titleComparative study of the biological properties of Trypanosoma cruzi I genotypes in a murine experimental modelspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
Archivos
Colecciones
Artículos