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Genome-wide association meta-analysis of 30,000 samples identifies seven novel loci for quantitative ECG traits

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dc.creatorvan Setten, Jessicaspa
dc.creatorVerweij, Niekspa
dc.creatorMbarek, Hamdispa
dc.creatorNiemeijer, Maartje N.spa
dc.creatorTrompet, Stellaspa
dc.creatorArking, Dan E.spa
dc.creatorBrody, Jennifer A.spa
dc.creatorGandin, Ilariaspa
dc.creatorGrarup, Nielsspa
dc.creatorHall, Leanne M.spa
dc.creatorHemerich, Daianespa
dc.creatorLyytikäinen, Leo-Pekkaspa
dc.creatorMei, Haospa
dc.creatorMüller-Nurasyid, Martinaspa
dc.creatorPrins, Bram P.spa
dc.creatorRobino, Antoniettaspa
dc.creatorSmith, Albert V.spa
dc.creatorWarren, Helen R.spa
dc.creatorAsselbergs, Folkert W.spa
dc.creatorBoomsma, Dorret I.spa
dc.creatorCaulfield, Mark J.spa
dc.creatorEijgelsheim, Markspa
dc.creatorFord, Ianspa
dc.creatorHansen, Torbenspa
dc.creatorHarris, Tamara B.spa
dc.creatorHeckbert, Susan R.spa
dc.creatorHottenga, Jouke-Janspa
dc.creatorIorio, Annamariaspa
dc.creatorKors, Jan A.spa
dc.creatorLinneberg, Allanspa
dc.creatorMacFarlane, Peter W.spa
dc.creatorMeitinger, Thomasspa
dc.creatorNelson, Christopher P.spa
dc.creatorRaitakari, Olli T.spa
dc.creatorSilva Aldana, Claudia T.spa
dc.creatorSinagra, Gianfrancospa
dc.creatorSinner, Moritzspa
dc.creatorSoliman, Elsayed Z.spa
dc.creatorStoll, Monikaspa
dc.creatorUitterlinden, Andrespa
dc.creatorvan Duijn, Cornelia M.spa
dc.creatorWaldenberger, Melaniespa
dc.creatorAlonso, Alvarospa
dc.creatorGasparini, Paolospa
dc.creatorGudnason, Vilmundurspa
dc.creatorJamshidi, Yaldaspa
dc.creatorKääb, Stefanspa
dc.creatorKanters, Jørgen K.spa
dc.creatorLehtimäki, Terhospa
dc.creatorMunroe, Patricia B.spa
dc.creatorPeters, Annettespa
dc.creatorSamani, Nilesh J.spa
dc.creatorSotoodehnia, Nonaspa
dc.creatorUlivi, Sheilaspa
dc.creatorWilson, James G.spa
dc.creatorde Geus, Eco J. C.spa
dc.creatorJukema, J. Wouterspa
dc.creatorStricker, Brunospa
dc.creatorvan der Harst, Pimspa
dc.creatorde Bakker, Paul I. W.spa
dc.creatorIsaacs, Aaronspa
dc.date.accessioned2020-05-26T00:07:29Z
dc.date.available2020-05-26T00:07:29Z
dc.date.created2019spa
dc.description.abstractGenome-wide association studies (GWAS) of quantitative electrocardiographic (ECG) traits in large consortia have identified more than 130 loci associated with QT interval, QRS duration, PR interval, and heart rate (RR interval). In the current study, we meta-analyzed genome-wide association results from 30,000 mostly Dutch samples on four ECG traits: PR interval, QRS duration, QT interval, and RR interval. SNP genotype data was imputed using the Genome of the Netherlands reference panel encompassing 19 million SNPs, including millions of rare SNPs (minor allele frequency less than 5%). In addition to many known loci, we identified seven novel locus-trait associations: KCND3, NR3C1, and PLN for PR interval, KCNE1, SGIP1, and NFKB1 for QT interval, and ATP2A2 for QRS duration, of which six were successfully replicated. At these seven loci, we performed conditional analyses and annotated significant SNPs (in exons and regulatory regions), demonstrating involvement of cardiac-related pathways and regulation of nearby genes. © 2019, The Author(s).eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1038/s41431-018-0295-z
dc.identifier.issn10184813
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/24006
dc.language.isoengspa
dc.publisherNature Publishing Groupspa
dc.relation.citationEndPage962
dc.relation.citationIssueNo. 6
dc.relation.citationStartPage952
dc.relation.citationTitleEuropean Journal of Human Genetics
dc.relation.citationVolumeVol. 27
dc.relation.ispartofEuropean Journal of Human Genetics, ISSN:10184813, Vol.27, No.6 (2019); pp. 952-962spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85060589966&doi=10.1038%2fs41431-018-0295-z&partnerID=40&md5=bde0cef16de811dba3fa2046484bba2aspa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordAllelespa
dc.subject.keywordArticlespa
dc.subject.keywordCohort analysisspa
dc.subject.keywordComputer modelspa
dc.subject.keywordDutchmanspa
dc.subject.keywordElectrocardiogramspa
dc.subject.keywordExonspa
dc.subject.keywordFollow upspa
dc.subject.keywordGene frequencyspa
dc.subject.keywordGene locusspa
dc.subject.keywordGene mappingspa
dc.subject.keywordGenomespa
dc.subject.keywordGenome-wide association studyspa
dc.subject.keywordGenotypespa
dc.subject.keywordHeart ratespa
dc.subject.keywordHumanspa
dc.subject.keywordMajor clinical studyspa
dc.subject.keywordMeta analysisspa
dc.subject.keywordNetherlandsspa
dc.subject.keywordPriority journalspa
dc.subject.keywordQrs intervalspa
dc.subject.keywordQt intervalspa
dc.subject.keywordQuantitative traitspa
dc.subject.keywordRr intervalspa
dc.subject.keywordSamplespa
dc.subject.keywordSingle nucleotide polymorphismspa
dc.titleGenome-wide association meta-analysis of 30,000 samples identifies seven novel loci for quantitative ECG traitsspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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