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Inferring natural selection signals in Plasmodium vivax-encoded proteins having a potential role in merozoite invasion

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dc.creatorGarzón-Ospina, Diegospa
dc.creatorForero-Rodríguez, Johannaspa
dc.creatorPatarroyo, Manuel A.spa
dc.date.accessioned2020-05-26T00:11:22Z
dc.date.available2020-05-26T00:11:22Z
dc.date.created2015spa
dc.description.abstractDetecting natural selection signals in Plasmodium parasites antigens might be used for identifying potential new vaccine candidates. Fifty-nine Plasmodium vivax-Sal-I genes encoding proteins having a potential role in invasion were used as query for identifying them in recent P. vivax strain genome sequences and two closely-related Plasmodium species. Several measures of DNA sequence variation were then calculated and selection signatures were detected by using different approaches. Our results may be used for determining which genes expressed during P. vivax merozoite stage could be prioritised for further population genetics or functional studies for designing a P. vivax vaccine which would avoid allele-specific immune responses. © 2015 Elsevier B.V.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1016/j.meegid.2015.05.001
dc.identifier.issn15671348
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/24298
dc.language.isoengspa
dc.publisherElsevierspa
dc.relation.citationEndPage188
dc.relation.citationStartPage182
dc.relation.citationTitleInfection, Genetics and Evolution
dc.relation.citationVolumeVol. 33
dc.relation.ispartofInfection, Genetics and Evolution, ISSN:15671348, Vol.33,(2015); pp. 182-188spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84937968357&doi=10.1016%2fj.meegid.2015.05.001&partnerID=40&md5=934f7175aaf224b658a820c53b1a295cspa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordAllelespa
dc.subject.keyworddnaeng
dc.subject.keywordDna polymorphismspa
dc.subject.keywordDna sequencespa
dc.subject.keywordGene mutationspa
dc.subject.keywordGenetic variabilityspa
dc.subject.keywordMerozoitespa
dc.subject.keywordMicrobial genespa
dc.subject.keywordMultigene familyspa
dc.subject.keywordNatural selectionspa
dc.subject.keywordNonhumanspa
dc.subject.keywordPlasmodium vivaxspa
dc.subject.keywordPriority journalspa
dc.subject.keywordSignal transductionspa
dc.subject.keywordBiologyspa
dc.subject.keywordGenetic polymorphismspa
dc.subject.keywordGenetic selectionspa
dc.subject.keywordGenetic variationspa
dc.subject.keywordGeneticsspa
dc.subject.keywordHost parasite interactionspa
dc.subject.keywordMetabolismspa
dc.subject.keywordPhylogenyspa
dc.subject.keywordPhysiologyspa
dc.subject.keywordPlasmodium vivaxspa
dc.subject.keywordPlasmodium parasitesspa
dc.subject.keywordPlasmodium vivaxspa
dc.subject.keywordProtozoal proteinspa
dc.subject.keywordComputational biologyspa
dc.subject.keywordGenetic variationspa
dc.subject.keywordHost-parasite interactionsspa
dc.subject.keywordPhylogenyspa
dc.subject.keywordPlasmodium vivaxspa
dc.subject.keywordPolymorphismeng
dc.subject.keywordProtozoan proteinsspa
dc.subject.keywordSelectioneng
dc.subject.keywordSequence analysiseng
dc.subject.keywordAllele-specific responsespa
dc.subject.keywordAnti-malarial vaccinespa
dc.subject.keywordNatural selection signalspa
dc.subject.keywordPlasmodium vivaxspa
dc.titleInferring natural selection signals in Plasmodium vivax-encoded proteins having a potential role in merozoite invasionspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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