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Trends and predictors of transmitted drug resistance (TDR) and clusters with TDR in a local Belgian HIV-1 epidemic

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dc.creatorPineda-Peña, Andrea-Clemencia
dc.creatorSchrooten, Yoeri
dc.creatorVinken, Lore
dc.creatorFerreira, Fossie
dc.creatorLi, Guangdi
dc.creatorSequeira Trovao, Nidia
dc.creatorKhouri, Ricardo
dc.creatorDerdelinckx, Inge
dc.creatorDe Munter, Paul
dc.creatorKücherer, Claudia
dc.creatorKostrikis, Leondios G.
dc.creatorNielsen, Claus
dc.creatorLittsol, Kirsi
dc.creatorWensing, Annemarie
dc.creatorStanojevic, Maja
dc.creatorParedes, Roger
dc.creatorBalotta, Claudia
dc.creatorAlbert, Jan
dc.creatorBoucher, Charles
dc.creatorGomez-Lopez, Arley
dc.creatorVan Wijngaerden, Eric
dc.creatorVan Ranst, Marc
dc.creatorVercauteren, Jurgen
dc.creatorVandamme, Anne-Mieke
dc.creatorVan Laethem, Kristel
dc.creator.googlePineda-Peña, Andrea-Clemenciaspa
dc.creator.googleSchrooten, Yoerispa
dc.creator.googleVinken, Lorespa
dc.creator.googleFerreira, Fossiespa
dc.creator.googleLi, Guangdispa
dc.creator.googleSequeira Trovao, Nidiaspa
dc.creator.googleKhouri, Ricardospa
dc.creator.googleDerdelinckx, Ingespa
dc.creator.googleDe Munter, Paulspa
dc.creator.googleKücherer, Claudiaspa
dc.creator.googleKostrikis, Leondios G.spa
dc.creator.googleNielsen, Clausspa
dc.creator.googleLittsol, Kirsispa
dc.creator.googleWensing, Annemariespa
dc.creator.googleStanojevic, Majaspa
dc.creator.googleParedes, Rogerspa
dc.creator.googleBalotta, Claudiaspa
dc.creator.googleAlbert, Janspa
dc.creator.googleBoucher, Charlesspa
dc.creator.googleGomez-Lopez, Arleyspa
dc.creator.googleVan Wijngaerden, Ericspa
dc.creator.googleVan Ranst, Marcspa
dc.creator.googleVercauteren, Jurgenspa
dc.creator.googleVandamme, Anne-Miekespa
dc.creator.googleVan Laethem, Kristelspa
dc.date.accessioned2018-11-19T14:30:19Z
dc.date.available2018-11-19T14:30:19Z
dc.date.created2014
dc.date.issued2014-07-08
dc.description.abstractWe aimed to study epidemic trends and predictors for transmitted drug resistance (TDR) in our region, its clinical impact and its association with transmission clusters. We included 778 patients from the AIDS Reference Center in Leuven (Belgium) diagnosed from 1998 to 2012. Resistance testing was performed using population-based sequencing and TDR was estimated using the WHO-2009 surveillance list. Phylogenetic analysis was performed using maximum likelihood and Bayesian techniques. The cohort was predominantly Belgian (58.4%), men who have sex with men (MSM) (42.8%), and chronically infected (86.5%). The overall TDR prevalence was 9.6% (95% confidence interval (CI): 7.7-11.9), 6.5% (CI: 5.0-8.5) for nucleoside reverse transcriptase inhibitors (NRTI), 2.2% (CI: 1.4-3.5) for non-NRTI (NNRTI), and 2.2% (CI: 1.4-3.5) for protease inhibitors. A significant parabolic trend of NNRTI-TDR was found (p = 0.019). Factors significantly associated with TDR in univariate analysis were male gender, Belgian origin, MSM, recent infection, transmission clusters and subtype B, while multivariate and Bayesian network analysis singled out subtype B as the most predictive factor of TDR. Subtype B was related with transmission clusters with TDR that included 42.6% of the TDR patients. Thanks to resistance testing, 83% of the patients with TDR who started therapy had undetectable viral load whereas half of the patients would likely have received a suboptimal therapy without this test. In conclusion, TDR remained stable and a NNRTI up-and-down trend was observed. While the presence of clusters with TDR is worrying, we could not identify an independent, non-sequence based predictor for TDR or transmission clusters with TDR that could help with guidelines or public health measures. © 2014 Pineda-Peña et al.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1371/journal.pone.0101738
dc.identifier.issn932 6203
dc.identifier.urihttp://repository.urosario.edu.co/handle/10336/18700
dc.language.isoengspa
dc.relation.citationEndPage14
dc.relation.citationIssueNo. 7
dc.relation.citationStartPage1
dc.relation.citationTitlePLoS ONE
dc.relation.citationVolumeVol. 9
dc.relation.ispartofPLoS ONE, ISSN: 1932-6203, Vol. 9/No. 7 (2014); pp.1-14spa
dc.relation.urihttps://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0101738&type=printablespa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.rights.cchttps://creativecommons.org/licenses/by/4.0/spa
dc.source.bibliographicCitationEpidemiologie van AIDS en HIV infectie in België. Epidemiologie du SIDA et de l'infection à VIH en Belgique (2012) Direction Opérationnelle Santé Publique et Surveillance, Service Maladies Infectieuses Au Sein de la Population Généra and Programme de Surveillance VIH/SIDA/IST, Editors, , ISP-WIVspa
dc.source.instnameinstname:Universidad del Rosario
dc.source.reponamereponame:Repositorio Institucional EdocUR
dc.subject.keywordAdultspa
dc.subject.keywordArticlespa
dc.subject.keywordFemalespa
dc.subject.keywordMiddle Agedspa
dc.subject.keywordAdultspa
dc.subject.keywordFemalespa
dc.subject.keywordHumansspa
dc.subject.keywordMiddle Agedspa
dc.subject.keywordRetrospective Studiesspa
dc.subject.keywordRisk Factorsspa
dc.subject.keywordProteinase Inhibitoreng
dc.subject.keywordRna Directed Dna Polymerase Inhibitoreng
dc.subject.keywordAnti Human Immunodeficiency Virus Agenteng
dc.subject.keywordAgedeng
dc.subject.keywordAntiviral Resistanceeng
dc.subject.keywordBelgiumeng
dc.subject.keywordCohort Analysiseng
dc.subject.keywordDisease Associationeng
dc.subject.keywordDisease Surveillanceeng
dc.subject.keywordEpidemiceng
dc.subject.keywordGendereng
dc.subject.keywordHumaneng
dc.subject.keywordVirus 1 Infectioneng
dc.subject.keywordImmunodeficiency Virus Typeeng
dc.subject.keyword1 Subtype Beng
dc.subject.keywordInfectioneng
dc.subject.keywordMajor Clinical Studyeng
dc.subject.keywordMaleeng
dc.subject.keywordMen Who Have Sex With Meneng
dc.subject.keywordPhylogenyeng
dc.subject.keywordPredictioneng
dc.subject.keywordPrevalenceeng
dc.subject.keywordSequence Analysiseng
dc.subject.keywordTransmitted Drug Resistanceeng
dc.subject.keywordTrend Studyeng
dc.subject.keywordVirus Loadeng
dc.subject.keywordVirus Transmissioneng
dc.subject.keywordAntiviral Resistanceeng
dc.subject.keywordCluster Analysiseng
dc.subject.keywordDrug Effectseng
dc.subject.keywordGeneticseng
dc.subject.keywordGenotypeeng
dc.subject.keywordHealth Surveyeng
dc.subject.keywordHiv Infectionseng
dc.subject.keywordMicrobial Sensitivity Testeng
dc.subject.keywordPregnancyeng
dc.subject.keywordRetrospective Studyeng
dc.subject.keywordRisk Factoreng
dc.subject.keywordTransmissioneng
dc.subject.keywordVirologyeng
dc.subject.keywordAnti-Hiv Agentseng
dc.subject.keywordBelgiumeng
dc.subject.keywordCluster Analysiseng
dc.subject.keywordDrug Resistanceeng
dc.subject.keywordViraleng
dc.subject.keywordGenotypeeng
dc.subject.lembEpidemiasspa
dc.subject.lembResistencia a medicamentosspa
dc.subject.lembSalud públicaspa
dc.titleTrends and predictors of transmitted drug resistance (TDR) and clusters with TDR in a local Belgian HIV-1 epidemicspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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