Ítem
Solo Metadatos

Recent advances in the development of a chemically synthesised anti-malarial vaccine

Mostrar el registro sencillo de la publicación
dc.creatorCurtidor, Hernando
dc.creatorPatarroyo, Manuel Espa
dc.creatorPatarroyo, Manuel A.
dc.date.accessioned2020-05-26T00:07:54Z
dc.date.available2020-05-26T00:07:54Z
dc.date.created2015spa
dc.description.abstractIntroduction: Obtaining an effective antimalarial vaccine has represented one of the biggest public health challenges over the last 50 years. Despite efforts by many laboratories around the world using whole-organism, recombinant proteins and genome-based approaches, the results have been disappointing. One of the main problems when designing an antimalarial vaccine is the poor immunogenicity induced by the functionally relevant and conserved protein regions of the parasite. Areas covered: This review focuses on the logical and rational methodology followed to identify Plasmodium falciparum conserved functional regions with the ability to bind to target cells conserved high activity binding peptides (cHABPs) and the physicochemical and immunological characteristics that should be taken into account for modifying them into highly immunogenic and protection-inducing peptides (mHABPs) into highly immunogenic and protection-inducing in Aotus monkeys. Expert opinion: The functional approach taken to develop a fully protective, minimal subunit-based, multiantigenic, multistage and synthetic peptide-based antimalarial vaccine has shown promising results. The clear relationship observed between mHABPs structure and their immunological properties highlights the challenges and opportunities arising from this methodology, as well as the universal principles and rules derived therefrom. © 2015 Taylor and Francis.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1517/14712598.2015.1075505
dc.identifier.issn14712598
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/24039
dc.language.isoengspa
dc.publisherTaylor and Francis Ltdspa
dc.relation.citationEndPage1581
dc.relation.citationIssueNo. 11
dc.relation.citationStartPage1567
dc.relation.citationTitleExpert Opinion on Biological Therapy
dc.relation.citationVolumeVol. 15
dc.relation.ispartofExpert Opinion on Biological Therapy, ISSN:14712598, Vol.15, No.11 (2015); pp. 1567-1581spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84946493025&doi=10.1517%2f14712598.2015.1075505&partnerID=40&md5=e59581654557988992dbe27d108dc13dspa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordBinding proteinspa
dc.subject.keywordplasmodiumeng
dc.subject.keywordSynthetic peptidespa
dc.subject.keywordMalaria vaccinespa
dc.subject.keywordPeptidespa
dc.subject.keywordProtein bindingspa
dc.subject.keywordProtozoal proteinspa
dc.subject.keywordRecombinant proteinspa
dc.subject.keywordRecombinant vaccinespa
dc.subject.keywordSpf66 proteineng
dc.subject.keywordSubunit vaccinespa
dc.subject.keywordAotusspa
dc.subject.keywordDrug efficacyspa
dc.subject.keywordDrug synthesisspa
dc.subject.keywordImmune responsespa
dc.subject.keywordImmunogenicityspa
dc.subject.keywordNonhumanspa
dc.subject.keywordPlasmodium falciparumspa
dc.subject.keywordReviewspa
dc.subject.keywordTarget cellspa
dc.subject.keywordChemistryspa
dc.subject.keywordHumanspa
dc.subject.keywordImmunologyspa
dc.subject.keywordMalariaspa
dc.subject.keywordMetabolismspa
dc.subject.keywordSynthesisspa
dc.subject.keywordHumansspa
dc.subject.keywordMalariaspa
dc.subject.keywordMalaria vaccinesspa
dc.subject.keywordPeptidesspa
dc.subject.keywordPlasmodium falciparumspa
dc.subject.keywordProtein bindingspa
dc.subject.keywordProtozoan proteinsspa
dc.subject.keywordRecombinant proteinsspa
dc.subject.keywordVaccineseng
dc.subject.keywordVaccineseng
dc.subject.keywordMalariaspa
dc.subject.keywordPlasmodiumspa
dc.subject.keywordRational designspa
dc.subject.keywordSynthetic peptidesspa
dc.subject.keywordVaccinespa
dc.titleRecent advances in the development of a chemically synthesised anti-malarial vaccinespa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
Archivos
Colecciones
Artículos