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Extended thromboprophylaxis for hip or knee arthroplasty. Does the administration route and dosage regimen affect adherence? A cohort study

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dc.creatorMoreno, Juan P.spa
dc.creatorBautista, Mariaspa
dc.creatorCastro, Jorgespa
dc.creatorBonilla, Guillermospa
dc.creatorLlinás, Adolfospa
dc.date.accessioned2020-05-25T23:55:40Z
dc.date.available2020-05-25T23:55:40Z
dc.date.created2020spa
dc.description.abstractPurpose: Prevention of thromboembolic disease requires patients’ adherence to the extended thromboprophylaxis scheme. Oral anticoagulants are expected to improve adherence as a result of their route of administration; however, this assumption is yet to be confirmed. The purpose of this study was to assess the impact of the route of administration and dosage regimen on the compliance to the prescription. Materials and methods: This prospective cohort study included hip and knee arthroplasty patients who received pharmacological extended thromboprophylaxis with one daily injection, one daily oral tablet, or two daily oral tablets. A telephonic questionnaire was applied 35 days after the day of the surgery. Patients who omitted one or more doses of medication during the follow-up period were classified as “non-adherent.” Differences of adherence rates were assessed. Results: Five hundred and twenty patients were included: 153 received Apixaban (oral, twice a day), 155 Enoxaparin (injectable, once a day), and 212 Rivaroxaban (oral, once a day). Patients receiving oral once a day medication was more compliant compared with those who received an oral medication twice a day. Non-adherence rates were 3.2 and 9.2%, respectively (p = 0.033). No significant differences (p = 0.360) were found between oral once a day and injectable once a day medication. Conclusions: The number of daily doses prescribed was related to adherence to extended chemical prophylaxis, while the route of administration did not seem to have a significant impact. Strategies to promote outpatient compliance must be implemented, especially when regimes including more than one daily dose are prescribed. © 2019, SICOT aisbl.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1007/s00264-019-04454-3
dc.identifier.issn14325195
dc.identifier.issn03412695
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/22169
dc.language.isoengspa
dc.publisherSpringerspa
dc.relation.citationEndPage243
dc.relation.citationIssueNo. 2
dc.relation.citationStartPage237
dc.relation.citationTitleInternational Orthopaedics
dc.relation.citationVolumeVol. 44
dc.relation.ispartofInternational Orthopaedics, ISSN:14325195, 03412695, Vol.44, No.2 (2020); pp. 237-243spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85075987543&doi=10.1007%2fs00264-019-04454-3&partnerID=40&md5=9f50da43ea6e555e85f45ff1222d2c7cspa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordApixabanspa
dc.subject.keywordEnoxaparinspa
dc.subject.keywordRivaroxabanspa
dc.subject.keywordAdolescentspa
dc.subject.keywordAdultspa
dc.subject.keywordAgedspa
dc.subject.keywordArticlespa
dc.subject.keywordBody massspa
dc.subject.keywordCohort analysisspa
dc.subject.keywordControlled studyspa
dc.subject.keywordDrug administration routespa
dc.subject.keywordDrug costspa
dc.subject.keywordDrug dose regimenspa
dc.subject.keywordDrug withdrawalspa
dc.subject.keywordEpistaxisspa
dc.subject.keywordFemalespa
dc.subject.keywordFollow upspa
dc.subject.keywordHealth statusspa
dc.subject.keywordHip arthroplastyspa
dc.subject.keywordHip fracturespa
dc.subject.keywordHumanspa
dc.subject.keywordKnee arthroplastyspa
dc.subject.keywordMajor clinical studyspa
dc.subject.keywordMalespa
dc.subject.keywordMedication compliancespa
dc.subject.keywordOsteoarthritisspa
dc.subject.keywordPatient compliancespa
dc.subject.keywordPractice guidelinespa
dc.subject.keywordPrescriptionspa
dc.subject.keywordPriority journalspa
dc.subject.keywordProspective studyspa
dc.subject.keywordThrombosis preventionspa
dc.subject.keywordVenous thromboembolismspa
dc.subject.keywordArthroplastyspa
dc.subject.keywordHipspa
dc.subject.keywordPrevention and controlspa
dc.subject.keywordReplacementspa
dc.subject.keywordVenous thromboembolismspa
dc.titleExtended thromboprophylaxis for hip or knee arthroplasty. Does the administration route and dosage regimen affect adherence? A cohort studyspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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