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Higher immunoglobulin production in conjugated linoleic acid-supplemented rats during gestation and suckling

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dc.creatorRamírez Santana, Heily Carolinaspa
dc.creatorPérez-Cano, Francisco J.spa
dc.creatorCastellote, Cristinaspa
dc.creatorCastell, Margaridaspa
dc.creatorRivero, Montserratspa
dc.creatorRodríguez-Palmero, Maríaspa
dc.creatorFranch, Ángelsspa
dc.date.accessioned2020-08-19T14:43:57Z
dc.date.available2020-08-19T14:43:57Z
dc.date.created2009-09-28spa
dc.description.abstractConjugated linoleic acid (CLA) has been reported to exert beneficial physiological effects on body composition and the immune system. However, little information is available on the influence of CLA on immune function during early life periods. The present study evaluates the effect of feeding an 80:20 mixture of cis-9, trans-11- and trans-10, cis-12-CLA isomers during gestation and suckling on the systemic immune response of weaned Wistar rats. Pups received dietary CLA from dams through the placental barrier and during suckling by breast milk (group A) or by oral administration (group B). Pups from group C only received CLA during suckling by oral administration. Group D constituted the reference group. Milk from dams fed the CLA diet had a high content of CLA and higher IgA and IgG concentrations than rats fed the standard diet. The plasma of pups from groups A, B and C showed six, twelve and nine times higher content of the cis-9, trans-11-CLA isomer than that of the group D pups. Rats from group A exhibited higher serum IgG concentrations than rats from the rest of the groups (22·14 (sem 2·14) v. about 5 mg/ml; P < 0·05), whereas rats from groups A and B showed approximately 2-fold higher splenocyte IgM production than rats from groups C and D. However, CLA supplementation did not influence significantly the splenocyte proliferative response or cytokine secretion. Supplementation during gestation and suckling with an 80:20 cis-9, trans-11–trans-10, cis-12 CLA mix enhances the production of the main in vivo and in vitro Ig isotypes in Wistar rats.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1017/S0007114509301592
dc.identifier.issnISSN: 0007-1145
dc.identifier.issnEISSN: 1475-2662
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/27801
dc.language.isoengspa
dc.publisherCambridge University Pressspa
dc.relation.citationEndPage868
dc.relation.citationIssueNo. 6
dc.relation.citationStartPage858
dc.relation.citationTitleBritish Journal of Nutrition
dc.relation.citationVolumeVol. 102
dc.relation.ispartofBritish Journal of Nutrition, ISSN: 0007-1145;EISSN: 1475-2662, Vol.102, No.6 (2009); pp. 858–868spa
dc.relation.urihttps://www.cambridge.org/core/services/aop-cambridge-core/content/view/D05A97F75586C2ED12847FB0E642A2D4/S0007114509301592a.pdf/higher_immunoglobulin_production_in_conjugated_linoleic_acidsupplemented_rats_during_gestation_and_suckling.pdfspa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.sourceBritish Journal of Nutritionspa
dc.source.instnameinstname:Universidad del Rosario
dc.source.reponamereponame:Repositorio Institucional EdocUR
dc.subject.keywordConjugated linoleic acidspa
dc.subject.keywordRatsspa
dc.subject.keywordGestationspa
dc.subject.keywordSucklingspa
dc.subject.keywordImmune responsespa
dc.titleHigher immunoglobulin production in conjugated linoleic acid-supplemented rats during gestation and sucklingspa
dc.title.TranslatedTitleMayor producción de inmunoglobulina en ratas suplementadas con ácido linoleico conjugado durante la gestación y la lactanciaspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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