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Cerebrovascular autoregulation in preterm fetal growth restricted neonates

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dc.creatorCohen E.spa
dc.creatorBaerts W.spa
dc.creatorCaicedo Dorado, Alexanderspa
dc.creatorNaulaers G.spa
dc.creatorVan Bel F.spa
dc.creatorLemmers P.M.A.spa
dc.date.accessioned2020-05-25T23:57:51Z
dc.date.available2020-05-25T23:57:51Z
dc.date.created2019spa
dc.description.abstractObjective To investigate the effect of fetal growth restriction (FGR) on cerebrovascular autoregulation in preterm neonates during the first 3 days of life. Design Case-control study. Setting Neonatal intensive care unit of the Wilhelmina Children's Hospital, The Netherlands. Patients 57 FGR (birth weight less than 10th percentile) and 57 appropriate for gestational age (AGA) (birth weight 20th-80th percentiles) preterm neonates, matched for gender, gestational age, respiratory and blood pressure support. Methods The correlation between continuously measured mean arterial blood pressure and regional cerebral oxygen saturation was calculated to generate the cerebral oximetry index (COx). Mean COx was calculated for each patient for each postnatal day. The percentage of time with impaired autoregulation (COx>0.5) was also calculated. Results FGR neonates had higher mean COx values than their AGA peers on day 2 (0.15 (95% CI 0.11 to 0.18) vs 0.09 (95% CI 0.06 to 0.13), p=0.029) and day 3 (0.17 (95% CI 0.13 to 0.20) vs 0.09 (95% CI 0.06 to 0.12), p=0.003) of life. FGR neonates spent more time with impaired autoregulation (COx value >0.5) than controls on postnatal day 2 (19% (95% CI 16% to 22%) vs 14% (95% CI 12% to 17%), p=0.035) and day 3 (20% (95% CI 17% to 24%) vs 15% (95% CI 12% to 18%), p=0.016). Conclusion FGR preterm neonates more frequently display impaired cerebrovascular autoregulation compared with AGA peers on days 2 and 3 of life which may predispose them to brain injury. Further studies are required to investigate whether this impairment persists beyond the first few days of life and whether this impairment is linked to poor neurodevelopmental outcome. © Author(s) (or their employer(s)) 2019.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1136/archdischild-2017-313712
dc.identifier.issn13592998
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/22755
dc.language.isoengspa
dc.publisherBMJ Publishing Groupspa
dc.relation.citationEndPageF472
dc.relation.citationIssueNo. 5
dc.relation.citationStartPageF467
dc.relation.citationTitleArchives of Disease in Childhood: Fetal and Neonatal Edition
dc.relation.citationVolumeVol. 104
dc.relation.ispartofArchives of Disease in Childhood: Fetal and Neonatal Edition, ISSN:13592998, Vol.104, No.5 (2019); pp. F467-F472spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85055502414&doi=10.1136%2farchdischild-2017-313712&partnerID=40&md5=36e1b4d7f69f02dec28f137c59620387spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordArticlespa
dc.subject.keywordPrematureeng
dc.subject.keywordNear-Infraredeng
dc.subject.keywordNeonataleng
dc.subject.keywordNewborneng
dc.subject.keywordPhysiologiceng
dc.subject.keywordAutoregulationspa
dc.subject.keywordBirth weightspa
dc.subject.keywordBlood pressurespa
dc.subject.keywordBlood pressure variabilityspa
dc.subject.keywordBrain blood vesselspa
dc.subject.keywordCase control studyspa
dc.subject.keywordControlled studyspa
dc.subject.keywordFemalespa
dc.subject.keywordGestational agespa
dc.subject.keywordHumanspa
dc.subject.keywordIntrauterine growth retardationspa
dc.subject.keywordMajor clinical studyspa
dc.subject.keywordMalespa
dc.subject.keywordMean arterial pressurespa
dc.subject.keywordNeonatal intensive care unitspa
dc.subject.keywordNetherlandsspa
dc.subject.keywordNewbornspa
dc.subject.keywordOximetryspa
dc.subject.keywordOxygen saturationspa
dc.subject.keywordPatient selectionspa
dc.subject.keywordPremature laborspa
dc.subject.keywordPrematurityspa
dc.subject.keywordPriority journalspa
dc.subject.keywordRetrospective studyspa
dc.subject.keywordBlood pressure measurementspa
dc.subject.keywordBrain circulationspa
dc.subject.keywordDevicesspa
dc.subject.keywordHomeostasisspa
dc.subject.keywordIntrauterine growth retardationspa
dc.subject.keywordNear infrared spectroscopyspa
dc.subject.keywordOxygen consumptionspa
dc.subject.keywordPathophysiologyspa
dc.subject.keywordPhysiologic monitoringspa
dc.subject.keywordPhysiologyspa
dc.subject.keywordProceduresspa
dc.subject.keywordPrognosisspa
dc.subject.keywordStatistics and numerical dataspa
dc.subject.keywordBirth Weightspa
dc.subject.keywordBlood Pressure Determinationspa
dc.subject.keywordCerebrovascular Circulationspa
dc.subject.keywordFemalespa
dc.subject.keywordFetal Growth Retardationspa
dc.subject.keywordGestational Agespa
dc.subject.keywordHomeostasisspa
dc.subject.keywordHumansspa
dc.subject.keywordInfanteng
dc.subject.keywordInfanteng
dc.subject.keywordIntensive Care Unitseng
dc.subject.keywordMalespa
dc.subject.keywordMonitoringeng
dc.subject.keywordNetherlandsspa
dc.subject.keywordOxygen Consumptionspa
dc.subject.keywordPrognosisspa
dc.subject.keywordSpectroscopyeng
dc.subject.keywordCerebrovascular autoregulationspa
dc.subject.keywordFetal growth restriction (FGR)spa
dc.subject.keywordIntrauterine growth restriction (IUGR)spa
dc.subject.keywordNear-infrared spectroscopy (NIRS)spa
dc.subject.keywordPrematurityspa
dc.titleCerebrovascular autoregulation in preterm fetal growth restricted neonatesspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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