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Annexin A2 autoantibodies in thrombosis and autoimmune diseases

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dc.creatorCañas, Felipespa
dc.creatorSimonin, Laurentspa
dc.creatorCouturaud, Francisspa
dc.creatorRenaudineau, Yvesspa
dc.date.accessioned2020-06-11T13:21:49Z
dc.date.available2020-06-11T13:21:49Z
dc.date.created2015-02spa
dc.description.abstractAntiphospholipid syndrome (APS) is an autoimmune disease characterized by arterial, venous or small-vessel thrombotic events, and recurrent miscarriages or fetal loss. APS diagnosis is based on the repeated detection of anti-phospholipid (PL) antibodies (Ab), typically associated with anti-beta 2 glycoproteinI (beta 2GPI)-Ab. Recent studies suggest that anti-beta 2GPI Ab activity involves a protein complex including beta 2GPI and annexin A2 (ANXA2). Anti-ANXA2 Ab recognizes this complex, and these Ab can effectively promote thrombosis by inhibiting plasmin generation, and by activating endothelial cells. Therefore, anti-ANXA2 Ab represent a new biomarker, which can be detected in up to 25% of APS patients. Moreover, anti-ANXA2 Ab have been detected, in thrombotic associated diseases including pre-eclampsia, in other autoimmune diseases, and in cancer. (C) 2014 Elsevier Ltd. All rights reserved.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1016/j.thromres.2014.11.034
dc.identifier.issn0049-3848
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/24917
dc.language.isoeng
dc.publisherThrombosis Researchspa
dc.relation.citationEndPage230
dc.relation.citationIssueNo. 2
dc.relation.citationStartPage226
dc.relation.citationTitleThrombosis Research
dc.relation.citationVolumeVol. 135
dc.relation.ispartofThrombosis Research, ISSN: 0049-3848, Vol.135, No.2 (2015-02); pp. 226-230spa
dc.relation.urihttps://app.dimensions.ai/details/publication/pub.1028914525spa
dc.rights.accesRightsinfo:eu-repo/semantics/closedAccess
dc.rights.accesoBloqueado (Texto referencial)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordAnnexin A2spa
dc.subject.keywordAntiphospholipid Syndromespa
dc.subject.keywordAutoantibodiesspa
dc.subject.keywordAutoimmune Diseasesspa
dc.subject.keywordHumansspa
dc.subject.keywordThrombosisspa
dc.titleAnnexin A2 autoantibodies in thrombosis and autoimmune diseasesspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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