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CCL3L1 and CCR5 influence cell-mediated immunity and affect HIV-AIDS pathogenesis via viral entry-independent mechanisms

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dc.creatorDolan M.J.spa
dc.creatorKulkarni H.spa
dc.creatorCamargo J.F.spa
dc.creatorHe W.spa
dc.creatorSmith A.spa
dc.creatorAnaya, Juan-Manuelspa
dc.creatorMiura T.spa
dc.creatorHecht F.M.spa
dc.creatorMamtani M.spa
dc.creatorPereyra F.spa
dc.creatorMarconi V.spa
dc.creatorMangano A.spa
dc.creatorSen L.spa
dc.creatorBologna R.spa
dc.creatorClark R.A.spa
dc.creatorAnderson S.A.spa
dc.creatorDelmar J.spa
dc.creatorO'Connell R.J.spa
dc.creatorLloyd A.spa
dc.creatorMartin J.spa
dc.creatorAhuja S.S.spa
dc.creatorAgan B.K.spa
dc.creatorWalker B.D.spa
dc.creatorDeeks S.G.spa
dc.creatorAhuja S.K.spa
dc.date.accessioned2020-05-25T23:57:18Z
dc.date.available2020-05-25T23:57:18Z
dc.date.created2007spa
dc.description.abstractAlthough host defense against human immunodeficiency virus 1 (HIV-1) relies mainly on cell-mediated immunity (CMI), the determinants of CMI in humans are poorly understood. Here we demonstrate that variations in the genes encoding the chemokine CCL3L1 and HIV coreceptor CCR5 influence CMI in both healthy and HIV-infected individuals. CCL3L1-CCR5 genotypes associated with altered CMI in healthy subjects were similar to those that influence the risk of HIV transmission, viral burden and disease progression. However, CCL3L1-CCR5 genotypes also modify HIV clinical course independently of their effects on viral load and CMI. These results identify CCL3L1 and CCR5 as major determinants of CMI and demonstrate that these host factors influence HIV pathogenesis through their effects on both CMI and other viral entry-independent mechanisms.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1038/ni1521
dc.identifier.issn15292908
dc.identifier.issn15292916
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/22641
dc.language.isoengspa
dc.relation.citationEndPage1336
dc.relation.citationIssueNo. 12
dc.relation.citationStartPage1324
dc.relation.citationTitleNature Immunology
dc.relation.citationVolumeVol. 8
dc.relation.ispartofNature Immunology, ISSN:15292908, 15292916, Vol.8, No.12 (2007); pp. 1324-1336spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-34548670468&doi=10.1038%2fni1521&partnerID=40&md5=522804359f154b13d68f9f4dbf646f9cspa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordChemokine receptor CCR5spa
dc.subject.keywordCellulareng
dc.subject.keywordMacrophage inflammatory protein 1alphaspa
dc.subject.keywordCCeng
dc.subject.keywordCCR5eng
dc.subject.keywordMacrophage inflammatory protein 1alpha L1spa
dc.subject.keywordUnclassified drugspa
dc.subject.keywordAcquired immune deficiency syndromespa
dc.subject.keywordAnimal experimentspa
dc.subject.keywordAnimal modelspa
dc.subject.keywordArticlespa
dc.subject.keywordCellular immunityspa
dc.subject.keywordControlled studyspa
dc.subject.keywordDisease coursespa
dc.subject.keywordDNA modificationspa
dc.subject.keywordGenetic associationspa
dc.subject.keywordGenetic variabilityspa
dc.subject.keywordGenotypespa
dc.subject.keywordHost resistancespa
dc.subject.keywordHumanspa
dc.subject.keywordHuman immunodeficiency virus 1spa
dc.subject.keywordHuman immunodeficiency virus infectionspa
dc.subject.keywordInfection riskspa
dc.subject.keywordMousespa
dc.subject.keywordNonhumanspa
dc.subject.keywordPathogenesisspa
dc.subject.keywordPriority journalspa
dc.subject.keywordVirus loadspa
dc.subject.keywordVirus transmissionspa
dc.subject.keywordVirus virulencespa
dc.subject.keywordAcquired Immunodeficiency Syndromespa
dc.subject.keywordChemokineseng
dc.subject.keywordGenotypespa
dc.subject.keywordHIV Infectionsspa
dc.subject.keywordHIV-1spa
dc.subject.keywordHumansspa
dc.subject.keywordImmunityeng
dc.subject.keywordReceptorseng
dc.subject.keywordViral Loadspa
dc.titleCCL3L1 and CCR5 influence cell-mediated immunity and affect HIV-AIDS pathogenesis via viral entry-independent mechanismsspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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