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Risk factors for methicillin-resistant Staphylococcus aureus bacteremia: A multicenter matched case-control study

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dc.creatorArias-Ortiz, Paola Marianaspa
dc.creatordel Pilar Calderón, Libiaspa
dc.creatorCastillo, Juan Sebastiánspa
dc.creatorMoreno-Montoya, Jose
dc.creatorLeal, Aura Lucíaspa
dc.creatorCortés, Jorge Albertospa
dc.creatorÁlvarez, Carlos Arturospa
dc.creatorGREBO, Grupospa
dc.date.accessioned2020-05-26T00:02:58Z
dc.date.available2020-05-26T00:02:58Z
dc.date.created2016spa
dc.description.abstractIntroduction: Methicillin-resistant Staphylococcus aureus is a frequent pathogen at critical care services. Its presence leads to increased hospital stays and mortality risk in patients with bacteremia. However, the etiology of this resistance marker has not been fully studied. Objective: To identify risk factors associated with the emergence of methicillin-resistant S. aureus bacteremia in critically ill patients treated at intensive care units in Bogotá, Colombia. Materials and methods: We conducted a retrospective paired case-control study, nested in a cohort of patients diagnosed with S. aureus bacteremia and treated at intensive care units between 2006 and 2008 in Bogotá. Cases were patients with positive blood culture to methicillin resistance, matched in a 1:1 ratio with methicillin-sensitive controls isolated from the same institution and hospitalization year. We used conditional logistic regression to analyze the risk factors associated with the presence of resistance, with emphasis on prior antibiotic therapy. Results: We included 372 patients with S. aureus bacteremia. Factors such as the use of pre-hospital devices: vascular (OR=1.986, 95% CI 1.038 to 3.801) and urinary (OR=2.559, 95% CI: 1.170 to 5.596), along with the number of previously used antibiotics, were associated with the emergence of resistance. The number of antibiotics used previously was determined to have a gradient effect, particularly carbapenems. Conclusions: The rational use of antibiotics and surveillance of exposure to surgical procedures or use of invasive devices are interventions that could diminish the emergence of methicillin-resistant S. aureus bacteremia causes.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.7705/biomedica.v36i4.3193
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/23545
dc.language.isoengspa
dc.publisherInstituto Nacional de Saludspa
dc.relation.citationEndPage619
dc.relation.citationIssueNo. 4
dc.relation.citationStartPage612
dc.relation.citationTitleBiomedica
dc.relation.citationVolumeVol. 36
dc.relation.ispartofBiomedica, Vol.36, No.4 (2016); pp. 612-619spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85013633728&doi=10.7705%2fbiomedica.v36i4.3193&partnerID=40&md5=cd3b32b7ff3f912dfd5e6023261df9a3spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordAntiinfective agentspa
dc.subject.keywordAdultspa
dc.subject.keywordAgespa
dc.subject.keywordAgedspa
dc.subject.keywordBacteremiaspa
dc.subject.keywordCase control studyspa
dc.subject.keywordClinical trialspa
dc.subject.keywordColombiaspa
dc.subject.keywordComorbidityspa
dc.subject.keywordCritical illnessspa
dc.subject.keywordCross infectionspa
dc.subject.keywordFemalespa
dc.subject.keywordHospitalizationspa
dc.subject.keywordHumanspa
dc.subject.keywordImmunocompromised patientspa
dc.subject.keywordIntensive care unitspa
dc.subject.keywordIsolation and purificationspa
dc.subject.keywordMalespa
dc.subject.keywordMethicillin resistant staphylococcus aureusspa
dc.subject.keywordMicrobiologyspa
dc.subject.keywordMiddle agedspa
dc.subject.keywordMulticenter studyspa
dc.subject.keywordPhysiologyspa
dc.subject.keywordPostoperative complicationspa
dc.subject.keywordPublic hospitalspa
dc.subject.keywordRisk factorspa
dc.subject.keywordSex factorspa
dc.subject.keywordStaphylococcus infectionspa
dc.subject.keywordTertiary care centerspa
dc.subject.keywordAdultspa
dc.subject.keywordAge factorsspa
dc.subject.keywordAgedspa
dc.subject.keywordAnti-bacterial agentsspa
dc.subject.keywordBacteremiaspa
dc.subject.keywordCase-control studiesspa
dc.subject.keywordColombiaspa
dc.subject.keywordComorbidityspa
dc.subject.keywordCritical illnessspa
dc.subject.keywordCross infectionspa
dc.subject.keywordFemalespa
dc.subject.keywordHospitalizationspa
dc.subject.keywordHospitalseng
dc.subject.keywordHumansspa
dc.subject.keywordImmunocompromised hostspa
dc.subject.keywordIntensive care unitsspa
dc.subject.keywordMalespa
dc.subject.keywordMethicillin-resistant staphylococcus aureusspa
dc.subject.keywordMiddle agedspa
dc.subject.keywordPostoperative complicationsspa
dc.subject.keywordRisk factorsspa
dc.subject.keywordSex factorsspa
dc.subject.keywordStaphylococcal infectionsspa
dc.subject.keywordTertiary care centersspa
dc.subject.keywordCase-control studiesspa
dc.subject.keywordDrug resistancespa
dc.subject.keywordIntensive care unitsspa
dc.subject.keywordMethicillin-resistant staphylococcus aureusspa
dc.subject.keywordMicrobialspa
dc.subject.keywordRisk factorsspa
dc.titleRisk factors for methicillin-resistant Staphylococcus aureus bacteremia: A multicenter matched case-control studyspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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