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Heterogeneous genetic diversity pattern in Plasmodium vivax genes encoding merozoite surface proteins (MSP) -7E, -7F and -7L

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dc.creatorGarzón-Ospina, Diego
dc.creatorForero Rodríguez, Johanna
dc.creatorPatarroyo, Manuel A.
dc.creator.googleGarzón-Ospina, Diegospa
dc.creator.googleForero-Rodríguez, Johannaspa
dc.creator.googlePatarroyo, Manuel Aspa
dc.date.accessioned2020-05-07T11:29:33Z
dc.date.available2020-05-07T11:29:33Z
dc.date.created2014
dc.date.issued2014
dc.description.abstractBackground: The msp-7 gene has become differentially expanded in the Plasmodium genus; Plasmodium vivax has the highest copy number of this gene, several of which encode antigenic proteins in merozoites. Methods: DNA sequences from thirty-six Colombian clinical isolates from P. vivax (pv) msp-7E, -7F and -7L genes were analysed for characterizing and studying the genetic diversity of these pvmsp-7 members which are expressed during the intra-erythrocyte stage; natural selection signals producing the variation pattern so observed were evaluated. Results: The pvmsp-7E gene was highly polymorphic compared to pvmsp-7F and pvmsp-7L which were seen to have limited genetic diversity; pvmsp-7E polymorphism was seen to have been maintained by different types of positive selection. Even though these copies seemed to be species-specific duplications, a search in the Plasmodium cynomolgi genome (P. vivax sister taxon) showed that both species shared the whole msp-7 repertoire. This led to exploring the long-term effect of natural selection by comparing the orthologous sequences which led to finding signatures for lineage-specific positive selection. Conclusions: The results confirmed that the P. vivax msp-7 family has a heterogeneous genetic diversity pattern; some members are highly conserved whilst others are highly diverse. The results suggested that the 3′-end of these genes encode MSP-7 proteins' functional region whilst the central region of pvmsp-7E has evolved rapidly. The lineage-specific positive selection signals found suggested that mutations occurring in msp-7s genes during host switch may have succeeded in adapting the ancestral P. vivax parasite population to humans. © 2014 Garzón-Ospina et al.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1186/1475-2875-13-495
dc.identifier.issn1475-2875
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/21889
dc.language.isoengspa
dc.relation.citationIssueNo. 1
dc.relation.citationTitleMalaria Journal
dc.relation.citationVolumeVol. 13
dc.relation.ispartofMalaria Journal, ISSN: 1475-2875 Vol. 13, No. 1 (2014)spa
dc.relation.urihttps://malariajournal.biomedcentral.com/track/pdf/10.1186/1475-2875-13-495spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosario
dc.source.reponamereponame:Repositorio Institucional EdocUR
dc.subject.ddcEnfermedadesspa
dc.subject.ddcEvolución & genéticaspa
dc.subject.keywordPlasmodium vivaxspa
dc.subject.keywordmsp-7spa
dc.subject.keywordGenetic diversityspa
dc.subject.keywordNatural selectionspa
dc.subject.keywordSelective sweepspa
dc.titleHeterogeneous genetic diversity pattern in Plasmodium vivax genes encoding merozoite surface proteins (MSP) -7E, -7F and -7Lspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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