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Genetic associations of leptin-related polymorphisms with systemic lupus erythematosus

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dc.creatorZhao, Jianspa
dc.creatorWu, Huispa
dc.creatorLangefeld, Carl D.spa
dc.creatorKaufman, Kenneth M.spa
dc.creatorKelly, Jennifer A.spa
dc.creatorBae, Sang-Cheolspa
dc.creatornetworks, Marta E. Alarcón-Riquelme for the BIOLUPUS and GENLESspa
dc.creatorAlarcón, Graciela S.spa
dc.creatorAnaya, Juan-Manuelspa
dc.creatorCriswell, Lindsey A.spa
dc.creatorFreedman, Barry I.spa
dc.creatorKamen, Diane L.spa
dc.creatorGilkeson, Gary S.spa
dc.creatorJacob, Chaim O.spa
dc.creatorJames, Judith A.spa
dc.creatorMerrill, Joan T.spa
dc.creatorGaffney, Patrick M.spa
dc.creatorSivils, Kathy Moserspa
dc.creatorNiewold, Timothy B.spa
dc.creatorPetri, Michellespa
dc.creatorSong, Seung Taekspa
dc.creatorJeong, Hye-jinspa
dc.creatorRamsey-Goldman, Rosalindspa
dc.creatorReveille, John D.spa
dc.creatorScofield, R. Halspa
dc.creatorStevens, Anne M.spa
dc.creatorBoackle, Susan A.spa
dc.creatorVilá, Luis M.spa
dc.creatorChang, Deh-Mingspa
dc.creatorSong, Yeong Wookspa
dc.creatorVyse, Timothy J.spa
dc.creatorHarley, John B.spa
dc.creatorBrown, Elizabeth E.spa
dc.creatorEdberg, Jeffrey C.spa
dc.creatorKimberly, Robert P.spa
dc.creatorHahn, Bevra H.spa
dc.creatorGrossman, Jennifer M.spa
dc.creatorTsao, Betty P.spa
dc.creatorLa Cava, Antoniospa
dc.date.accessioned2020-05-26T00:04:25Z
dc.date.available2020-05-26T00:04:25Z
dc.date.created2015spa
dc.description.abstractLeptin is abnormally elevated in the plasma of patients with systemic lupus erythematosus (SLE), where it is thought to promote and/or sustain pro-inflammatory responses. Whether this association could reflect an increased genetic susceptibility to develop SLE is not known, and studies of genetic associations with leptin-related polymorphisms in SLE patients have been so far inconclusive. Here we genotyped DNA samples from 15,706 SLE patients and healthy matched controls from four different ancestral groups, to correlate polymorphisms of genes of the leptin pathway to risk for SLE. It was found that although several SNPs showed weak associations, those associations did not remain significant after correction for multiple testing. These data do not support associations between defined leptin-related polymorphisms and increased susceptibility to develop SLE. © 2015 Elsevier Inc.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1016/j.clim.2015.09.007
dc.identifier.issn15217035
dc.identifier.issn15216616
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/23683
dc.language.isoengspa
dc.publisherAcademic Press Inc.spa
dc.relation.citationEndPage162
dc.relation.citationIssueNo. 2
dc.relation.citationStartPage157
dc.relation.citationTitleClinical Immunology
dc.relation.citationVolumeVol. 161
dc.relation.ispartofClinical Immunology, ISSN:15217035, 15216616, Vol.161, No.2 (2015); pp. 157-162spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84942900473&doi=10.1016%2fj.clim.2015.09.007&partnerID=40&md5=f534aa6109e09fb0476e966fa4d201c2spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordLeptinspa
dc.subject.keywordsystemiceng
dc.subject.keywordLeptinspa
dc.subject.keywordsingle nucleotideeng
dc.subject.keywordAfrican americanspa
dc.subject.keywordArticlespa
dc.subject.keywordControlled studyspa
dc.subject.keywordDna determinationspa
dc.subject.keywordEast asianspa
dc.subject.keywordEuropean americanspa
dc.subject.keywordGenespa
dc.subject.keywordGenetic associationspa
dc.subject.keywordGenetic riskspa
dc.subject.keywordGenetic susceptibilityspa
dc.subject.keywordGenotypespa
dc.subject.keywordGhsr genespa
dc.subject.keywordHispanicspa
dc.subject.keywordHumanspa
dc.subject.keywordInflammationspa
dc.subject.keywordLep genespa
dc.subject.keywordLepr genespa
dc.subject.keywordMajor clinical studyspa
dc.subject.keywordPparg genespa
dc.subject.keywordPriority journalspa
dc.subject.keywordSingle nucleotide polymorphismspa
dc.subject.keywordSystemic lupus erythematosusspa
dc.subject.keywordCase control studyspa
dc.subject.keywordGenetic predispositionspa
dc.subject.keywordGeneticsspa
dc.subject.keywordSingle nucleotide polymorphismspa
dc.subject.keywordSystemic lupus erythematosusspa
dc.subject.keywordCase-control studiesspa
dc.subject.keywordGenetic predisposition to diseasespa
dc.subject.keywordGenotypespa
dc.subject.keywordHumansspa
dc.subject.keywordLeptinspa
dc.subject.keywordLupus erythematosuseng
dc.subject.keywordPolymorphismeng
dc.subject.keywordGene polymorphismsspa
dc.subject.keywordLeptin pathwayspa
dc.subject.keywordSystemic lupus erythematosusspa
dc.titleGenetic associations of leptin-related polymorphisms with systemic lupus erythematosusspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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