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Malaria parasite survival depends on conserved binding peptides’ critical biological functions

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dc.creatorPatarroyo M.E.spa
dc.creatorArévalo-Pinzón G.spa
dc.creatorReyes C.spa
dc.creatorMoreno-Vranich A.spa
dc.creatorPatarroyo M.A.spa
dc.date.accessioned2020-05-26T00:05:38Z
dc.date.available2020-05-26T00:05:38Z
dc.date.created2016spa
dc.description.abstractBiochemical, structural and single amino acid level analysis of 49 Plasmodium falciparum protein regions (13 sporozoite and 36 merozoite proteins) has highlighted the functional role of each conserved high activity binding peptide (cHABP) in cell host-microbe interaction, involving biological functions such as gliding motility, traversal activity, binding invasion, reproduction, nutrient ion transport and the development of severe malaria. Each protein's key function in the malaria parasite's asexual lifecycle (pre-erythrocyte and erythro-cyte) is described in terms of cHABPs; their sequences were located in elegant work published by other groups regarding critical binding regions implicated in malarial parasite invasion. Such cHABPs represent the starting point for developing a logical and rational methodology for selecting an appropriate mixture of modified cHABPs to be used in a completely effective, synthetic antimalarial vaccine. Such methodology could be used for developing vaccines against diseases scourging humanity. © 2016, Caister Academic Press. All rights reserved.eng
dc.format.mimetypeapplication/pdf
dc.identifier.issn14673037
dc.identifier.issn14673045
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/23812
dc.language.isoengspa
dc.publisherCaister Academic Pressspa
dc.relation.citationEndPage78
dc.relation.citationIssueNo. 1
dc.relation.citationStartPage57
dc.relation.citationTitleCurrent Issues in Molecular Biology
dc.relation.citationVolumeVol. 18
dc.relation.ispartofCurrent Issues in Molecular Biology, ISSN:14673037, 14673045, Vol.18, No.1 (2016); pp. 57-78spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84941005868&partnerID=40&md5=5ffb310e3d89a6d468a8a12959b1799bspa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordCalcium ionspa
dc.subject.keywordfalciparumeng
dc.subject.keywordEpidermal growth factorspa
dc.subject.keywordErythrocyte membrane protein 1spa
dc.subject.keywordMembrane proteinspa
dc.subject.keywordMicroorganism proteinspa
dc.subject.keywordProtein clag 3 2spa
dc.subject.keywordProtein csp 1spa
dc.subject.keywordProtein msp1spa
dc.subject.keywordProtein msp2spa
dc.subject.keywordProtein pf12spa
dc.subject.keywordProtein pf38spa
dc.subject.keywordProtein pf41spa
dc.subject.keywordProtein pfrhspa
dc.subject.keywordProtein ptrampspa
dc.subject.keywordProtein ramaspa
dc.subject.keywordProtein rh2aspa
dc.subject.keywordProtein rh2bspa
dc.subject.keywordProtein rh4spa
dc.subject.keywordProtein rhoph3spa
dc.subject.keywordSialic acidspa
dc.subject.keywordUnclassified drugspa
dc.subject.keywordPeptidespa
dc.subject.keywordProtozoal proteinspa
dc.subject.keywordAmino acid sequencespa
dc.subject.keywordArticlespa
dc.subject.keywordBinding sitespa
dc.subject.keywordDisease associationspa
dc.subject.keywordErythrocytespa
dc.subject.keywordHost parasite interactionspa
dc.subject.keywordHumanspa
dc.subject.keywordLiverspa
dc.subject.keywordMalariaspa
dc.subject.keywordMerozoitespa
dc.subject.keywordNonhumanspa
dc.subject.keywordParasite migrationspa
dc.subject.keywordParasite survivalspa
dc.subject.keywordPlasmodium falciparumspa
dc.subject.keywordProtein bindingspa
dc.subject.keywordProtein domainspa
dc.subject.keywordProtein expressionspa
dc.subject.keywordRegulatory mechanismspa
dc.subject.keywordSporozoitespa
dc.subject.keywordTight junctionspa
dc.subject.keywordHep-g2 cell linespa
dc.subject.keywordHost parasite interactionspa
dc.subject.keywordMalaria falciparumspa
dc.subject.keywordParasitologyspa
dc.subject.keywordPhysiologyspa
dc.subject.keywordPlasmodium falciparumspa
dc.subject.keywordErythrocytesspa
dc.subject.keywordHep g2 cellsspa
dc.subject.keywordHost-parasite interactionsspa
dc.subject.keywordHumansspa
dc.subject.keywordMalariaeng
dc.subject.keywordPeptidesspa
dc.subject.keywordPlasmodium falciparumspa
dc.subject.keywordProtozoan proteinsspa
dc.subject.keywordSporozoitesspa
dc.titleMalaria parasite survival depends on conserved binding peptides’ critical biological functionsspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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