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Human Papillomavirus Genotypes From Vaginal and Vulvar Intraepithelial Neoplasia in Females 15–26 Years of Age

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dc.creatorGarland, Suzanne M.spa
dc.creatorJoura, Elmar A.spa
dc.creatorAult, Kevin A.spa
dc.creatorBosch, F. Xavierspa
dc.creatorBrown, Darron R.spa
dc.creatorCastellsagué, Xavierspa
dc.creatorFerenczy, Alexspa
dc.creatorFerris, Daron G.spa
dc.creatorGiuliano, Anna R.spa
dc.creatorHernandez-Avila, Mauriciospa
dc.creatorHuh, Warner K.spa
dc.creatorIversen, Ole-Erikspa
dc.creatorKjaer, Susanne K.spa
dc.creatorKurman, Robert J.spa
dc.creatorLuna, Joaquinspa
dc.creatorMonsonego, Josephspa
dc.creatorMuñoz, Nubiaspa
dc.creatorPaavonen, Jormaspa
dc.creatorPitisuttihum, Punneespa
dc.creatorRonnett, Brigitte M.spa
dc.creatorSteben, Marcspa
dc.creatorStoler, Mark H.spa
dc.creatorWheeler, Cosette M.spa
dc.creatorWiley, Dorothy J.spa
dc.creatorPerez, Gonzalospa
dc.creatorSaah, Alfred J.spa
dc.creatorLuxembourg, Alainspa
dc.creatorLispa
dc.creatorDiNubile, Mark J.spa
dc.creatorWagner, Monikaspa
dc.creatorVelicer, Christinespa
dc.date.accessioned2020-06-11T13:21:15Z
dc.date.available2020-06-11T13:21:15Z
dc.date.created2018-08spa
dc.description.abstractOBJECTIVE: To estimate the proportion of vulvar and vaginal low-grade and high-grade squamous intraepithelial lesions (LSILs and HSILs) in females 15-26 years of age attributable to 14 human papillomavirus (HPV) genotypes (6, 11, 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59).METHODS: A post hoc analysis of prospectively diagnosed vulvar and vaginal LSILs and HSILs among females 15-26 years of age enrolled in the placebo arms of two phase 3, randomized HPV vaccine trials assessed 14 prespecified HPV genotypes associated with cervical cancers or anogenital warts using a type-specific multiplex polymerase chain reaction assay. The frequency of lesions associated with specific HPV genotypes was estimated by proportional and other attribution methods.RESULTS: During approximately 4 years of follow-up in 8,798 females, 40 vulvar LSILs and 46 vulvar HSILs were diagnosed in 68 females, and 118 vaginal LSILs and 33 vaginal HSILs were diagnosed in 107 females. Females developing vulvar (41.2%) or vaginal (49.5%) lesions also had cervical lesions, whereas 6.5% of females with cervical lesions had vaginal or vulvar lesions. At least 1 of the 14 HPV genotypes was detected in females with vulvar LSIL (72.5%), vulvar HSIL (91.3%), vaginal LSIL (61.9%), and vaginal HSIL (72.7%). Considering only HPV-positive lesions, the nine most common genotypes causing cervical cancer and anogenital warts (6, 11, 16, 18, 31, 33, 45, 52, and 58) were found in 89.4% of vulvar LSILs, 100% of vulvar HSILs, 56.0% of vaginal LSILs, and 78.3% of vaginal HSILs.CONCLUSION: Most vulvar and vaginal lesions were attributable to at least 1 of the 14 HPV genotypes analyzed. Effective immunization programs could potentially prevent substantial numbers of HPV-related vulvar and vaginal LSILs and HSILs.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1097/aog.0000000000002736
dc.identifier.issn0029-7844
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/24791
dc.language.isoeng
dc.publisherObstetrics and Gynecologyspa
dc.relation.citationEndPage270
dc.relation.citationIssueNo. 2
dc.relation.citationStartPage261
dc.relation.citationTitleObstetrics and Gynecology
dc.relation.citationVolumeVol. 132
dc.relation.ispartofObstetrics and Gynecology, ISSN: 0029-7844, Vol.132, No.2 (2018-08); pp. 261-270spa
dc.relation.urihttp://pdfs.semanticscholar.org/a42a/558c272876d1a865988ccdfaa6752a308392.pdfspa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordAdolescentspa
dc.subject.keywordAdultspa
dc.subject.keywordCarcinoma in Situspa
dc.subject.keywordFemalespa
dc.subject.keywordGenotypespa
dc.subject.keywordHumansspa
dc.subject.keywordPapillomaviridaespa
dc.subject.keywordPapillomavirus Infectionsspa
dc.subject.keywordPapillomavirus Vaccinesspa
dc.subject.keywordPlacebosspa
dc.subject.keywordUterine Cervical Neoplasmsspa
dc.subject.keywordVaginal Neoplasmsspa
dc.subject.keywordVulvar Neoplasmsspa
dc.subject.keywordYoung Adultspa
dc.titleHuman Papillomavirus Genotypes From Vaginal and Vulvar Intraepithelial Neoplasia in Females 15–26 Years of Agespa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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