Ítem
Acceso Abierto

Challenges in the diagnosis and management of acromegaly: a focus on comorbidities

Mostrar el registro sencillo de la publicación
dc.creatorAbreu, Alinspa
dc.creatorTovar, Alejandro Pinzónspa
dc.creatorCastellanos, Rafaelspa
dc.creatorValenzuela, Alexspa
dc.creatorGiraldo, Claudia Milena Gómezspa
dc.creatorPinedo, Alejandro Castellanosspa
dc.creatorGuerrero, Doly Pantojaspa
dc.creatorBarrera, Carlos Alfonso Builesspa
dc.creatorFranco, Humberto Ignaciospa
dc.creatorRibeiro-Oliveira, Antôniospa
dc.creatorVilar, Luciospa
dc.creatorJallad, Raquel S.spa
dc.creatorDuarte, Felipe Gaiaspa
dc.creatorGadelha, Mônicaspa
dc.creatorBoguszewski, Cesar Luizspa
dc.creatorAbucham, Juliospa
dc.creatorNaves, Luciana A.spa
dc.creatorMusolino, Nina Rosa C.spa
dc.creatorde Faria, Maria Estela Justamantespa
dc.creatorRossato, Cilianaspa
dc.creatorBronstein, Marcello D.spa
dc.date.accessioned2020-05-25T23:58:11Z
dc.date.available2020-05-25T23:58:11Z
dc.date.created2016spa
dc.description.abstractIntroduction: Acromegaly is a rare, insidious disease resulting from the overproduction of growth hormone (GH) and insulin-like growth factor 1 (IGF-1), and is associated with a range of comorbidities. The extent of associated complications and mortality risk is related to length of exposure to the excess GH and IGF-1, thus early diagnosis and treatment is imperative. Unfortunately, acromegaly is often diagnosed late, when patients already have a wide range of comorbidities. The presence of comorbid conditions contributes significantly to patient morbidity/mortality and impaired quality of life. Methods: We conducted a retrospective literature review for information relating to the diagnosis of acromegaly, and its associated comorbidities using PubMed. The main aim of this review is to highlight the issues of comorbidities in acromegaly, and to reinforce the importance of early diagnosis and treatment. Findings and conclusions: Successful management of acromegaly goes beyond treating the disease itself, since many patients are diagnosed late in disease evolution, they present with a range of comorbid conditions, such as cardiovascular disease, diabetes, hypertension, and sleep apnea. It is important that patients are screened carefully at diagnosis (and thereafter), for common associated complications, and that biochemical control does not become the only treatment goal. Mortality and morbidities in acromegaly can be reduced successfully if patients are treated using a multimodal approach with comprehensive comorbidity management. © 2016, The Author(s).eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1007/s11102-016-0725-2
dc.identifier.issn15737403
dc.identifier.issn1386341X
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/22816
dc.language.isoengspa
dc.publisherSpringer New York LLCspa
dc.relation.citationEndPage457
dc.relation.citationIssueNo. 4
dc.relation.citationStartPage448
dc.relation.citationTitlePituitary
dc.relation.citationVolumeVol. 19
dc.relation.ispartofPituitary, ISSN:15737403, 1386341X, Vol.19, No.4 (2016); pp. 448-457spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84976320997&doi=10.1007%2fs11102-016-0725-2&partnerID=40&md5=97d28c711dc98fa084af523880077528spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordGrowth hormonespa
dc.subject.keywordleft ventriculareng
dc.subject.keywordSomatomedin cspa
dc.subject.keywordleft ventriculareng
dc.subject.keywordAcromegalyspa
dc.subject.keywordArthropathyspa
dc.subject.keywordCardiovascular diseasespa
dc.subject.keywordComorbidityspa
dc.subject.keywordCraniofacial developmentspa
dc.subject.keywordEndocrine diseasespa
dc.subject.keywordHormone synthesisspa
dc.subject.keywordHumanspa
dc.subject.keywordLung diseasespa
dc.subject.keywordMalignant neoplastic diseasespa
dc.subject.keywordMental diseasespa
dc.subject.keywordMetabolic disorderspa
dc.subject.keywordMorbidityspa
dc.subject.keywordMortalityspa
dc.subject.keywordNeurologic diseasespa
dc.subject.keywordPriority journalspa
dc.subject.keywordQuality of lifespa
dc.subject.keywordRetrospective studyspa
dc.subject.keywordReviewspa
dc.subject.keywordRheumatic diseasespa
dc.subject.keywordAdenomaspa
dc.subject.keywordCardiovascular diseasesspa
dc.subject.keywordCarpal tunnel syndromespa
dc.subject.keywordComorbidityspa
dc.subject.keywordComplicationspa
dc.subject.keywordDiabetes mellitusspa
dc.subject.keywordDisease managementspa
dc.subject.keywordGrowth hormone-secreting pituitary adenomaspa
dc.subject.keywordHeadachespa
dc.subject.keywordHeart failurespa
dc.subject.keywordHypertensionspa
dc.subject.keywordHypertrophyeng
dc.subject.keywordMacroglossiaspa
dc.subject.keywordOsteoarthritisspa
dc.subject.keywordPrognosisspa
dc.subject.keywordSleep apnea syndromesspa
dc.subject.keywordVision disordersspa
dc.subject.keywordAdenomaspa
dc.subject.keywordCardiovascular diseasesspa
dc.subject.keywordCarpal tunnel syndromespa
dc.subject.keywordComorbidityspa
dc.subject.keywordDiabetes mellitusspa
dc.subject.keywordDisease managementspa
dc.subject.keywordGrowth hormone-secreting pituitary adenomaspa
dc.subject.keywordHeadachespa
dc.subject.keywordHeart failurespa
dc.subject.keywordHumansspa
dc.subject.keywordHypertensionspa
dc.subject.keywordHypertrophyeng
dc.subject.keywordMacroglossiaspa
dc.subject.keywordOsteoarthritisspa
dc.subject.keywordPrognosisspa
dc.subject.keywordSleep apnea syndromesspa
dc.subject.keywordVision disordersspa
dc.subject.keywordAcromegaly comorbiditiesspa
dc.subject.keywordAcromegaly diagnosisspa
dc.subject.keywordLatin americaspa
dc.titleChallenges in the diagnosis and management of acromegaly: a focus on comorbiditiesspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
Archivos
Bloque original
Mostrando1 - 1 de 1
Miniatura
Nombre:
Abreu2016_Article_ChallengesInTheDiagnosisAndMan.pdf
Tamaño:
429.25 KB
Formato:
Adobe Portable Document Format
Descripción:
Descargar
Colecciones
Artículos