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Noradrenaline acting at central ?-adrenoceptors induces interleukin-10 and suppressor of cytokine signaling-3 expression in rat brain: Implications for neurodegeneration

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dc.creatorMcNameea, Eon N.spa
dc.creatorRyana, Karen M.spa
dc.creatorGriffin, Éadaoin W.spa
dc.creatorGonzález Reyes, Rodrigo Estebanspa
dc.creatorRyana, Katie J.spa
dc.creatorHarkin, Andrewspa
dc.creatorConnor, Thomas J.spa
dc.date.accessioned2020-08-06T16:20:13Z
dc.date.available2020-08-06T16:20:13Z
dc.date.created2010-05-01spa
dc.description.abstractEvidence indicates that the monoamine neurotransmitter noradrenaline elicits anti-inflammatory actions in the central nervous system (CNS), and consequently may play a neuroprotective role where inflammatory events contribute to CNS pathology. Here we examined the ability of pharmacologically enhancing central noradrenergic tone to induce expression of anti-inflammatory cytokines in rat brain. Administration of the noradrenaline reuptake inhibitor reboxetine (15 mg/kg; ip) combined with the ?2-adrenoceptor antagonist idazoxan (1 mg/kg; ip) induced interleukin-10 (IL-10) expression in rat cortex and hippocampus. In addition, these drug treatments induced IL-10 signaling as indicated by increased STAT3 phosphorylation and suppressor of cytokine signaling-3 (SOCS-3) mRNA expression. In contrast to the profound increase in IL-10 induced by the reboxetine/idazoxan combination, the other two broad spectrum anti-inflammatory cytokines IL-4 and TGF-? were not induced by this treatment. The ability of combined treatment with reboxetine and idazoxan to induce IL-10 and SOCS3 expression was mediated by ?-adrenoceptor activation, as their induction was blocked by pre-treatment with the ?-adrenoceptor antagonist propranolol. Moreover, administration of the brain penetrant ?2-adrenoceptor agonist clenbuterol induced a time- and dose-dependent increase in central IL-10 and SOCS3 expression, and the ability of clenbuterol to induce IL-10 and SOCS-3 expression was blocked by the centrally acting ?-adrenoceptor antagonist, propranolol, and was mimicked by the highly selective ?2-adrenoceptor agonist formoterol. In all, these data indicate that increasing central noradrenergic tone induces IL-10 production and signaling in the CNS, which may protect against neurodegeneration.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1016/j.bbi.2010.02.005
dc.identifier.issnISSN: 0889-1591
dc.identifier.issnEISSN: 1090-2139
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/25919
dc.language.isoengspa
dc.publisherElsevierspa
dc.relation.citationEndPage671
dc.relation.citationIssueNo. 4
dc.relation.citationStartPage660
dc.relation.citationTitleBrain, Behavior, and Immunity
dc.relation.citationVolumeVol. 24
dc.relation.ispartofBrain, Behavior, and Immunity, ISSN: 0889-1591;EISSN: 1090-2139, Vol.24, No.4 (2010);pp.660-671spa
dc.relation.urihttps://www.sciencedirect.com/science/article/abs/pii/S0889159110000474?via%3Dihubspa
dc.rights.accesRightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.accesoRestringido (Acceso a grupos específicos)spa
dc.sourceBrain, Behavior, and Immunityspa
dc.source.instnameinstname:Universidad del Rosario
dc.source.reponamereponame:Repositorio Institucional EdocUR
dc.subject.keywordIL-10spa
dc.subject.keywordSOCS3spa
dc.subject.keywordNoradrenalinespa
dc.subject.keyword?-Adrenoceptorspa
dc.subject.keywordSTAT3spa
dc.subject.keywordBrainspa
dc.subject.keywordAnti-inflammatoryspa
dc.titleNoradrenaline acting at central ?-adrenoceptors induces interleukin-10 and suppressor of cytokine signaling-3 expression in rat brain: Implications for neurodegenerationspa
dc.title.TranslatedTitleLa noradrenalina que actúa en los ?-adrenoceptores centrales induce la interleucina-10 y el supresor de la expresión de la citocina señalización-3 en el cerebro de rata: implicaciones para la neurodegeneraciónspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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