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Asociación entre genotipos FTO (ns9939609) y marcadores de adiposidad en adultos chilenos

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dc.creatorPetermann, Fannyspa
dc.creatorVillagran, Marcelospa
dc.creatorTroncoso, Claudiaspa
dc.creatorMardones, Lorenaspa
dc.creatorMaria Leiva, Anaspa
dc.creatorAdela Martinez, Mariaspa
dc.creatorAlexgarrido-Mendezspa
dc.creatorFelipepoblete-Valderramaspa
dc.creatorSalas-Bravo, Carlosspa
dc.creatorRamírez-Vélez, Robinson
dc.creatorUlloa, Nataliaspa
dc.creatorPerez-Bravo, Franciscospa
dc.creatorCelis-Morales, Carlosspa
dc.date.accessioned2020-06-11T13:22:13Z
dc.date.available2020-06-11T13:22:13Z
dc.date.created2018spa
dc.description.abstractBackground: Numerous studies have identified the role of Fat-mass-associated-gene (FTO) in the development of obesity. Aim: To investigate the association of FTO gene with adiposity markers in Chilean adults. Material and Methods: 409 participants were included in this cross-sectional study. The association between FTO (rs9939609) genotype and adiposity markers was determined using linear regression analyses. Adiposity markers included were: body weight, body mass index, fat mass, waist circumference, hip circumference and waist/hip ratio. Results: A fully adjusted model showed a significant association between FTO genotype and body weight (2.16 kg per each extra copy of the risk allele [95% confidence intervals (CI): 0.45 to 3.87], p = 0.014), body mass index (0.61 kg.m(-2) [95% CI: 0.12 to 1.20], p = 0.050) and fat mass (1.14% [95% CI: 0.39 to 1.89], p = 0.010). The greater magnitude of association was found between the FTO gene and fat mass when the outcomes were standardized to z-score. Conclusions: This study confirms an association between the FTO gene and adiposity markers in Chilean adults, which is independent of major confounding factors.spa
dc.format.mimetypeapplication/pdf
dc.identifier.issn0034-9887
dc.identifier.issn0717-6163
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/25061
dc.language.isospa
dc.publisherSociedad Medica de Santiagospa
dc.relation.citationEndPage726
dc.relation.citationIssueNo. 6
dc.relation.citationStartPage717
dc.relation.citationTitleREVISTA MEDICA DE CHILE
dc.relation.citationVolumeVol. 146
dc.relation.ispartofREVISTA MEDICA DE CHILE, ISSN:0034-9887 ; 0717-6163, Vol.146, No.6 (2018); pp. 717-726spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subjectAdiposidadspa
dc.subjectAlfa-cetoglutarato-dependiente dioxigenasa FTOspa
dc.subjectGenotipospa
dc.subjectObesidadspa
dc.subjectObesidadspa
dc.subjectGenespa
dc.subjectPoblaciónspa
dc.subjectInfanciaspa
dc.subjectVariantesspa
dc.subjectNiñosspa
dc.subjectPesospa
dc.subject.keywordAdiposityspa
dc.subject.keywordAlpha-Ketoglutarate-Dependent Dioxygenase FTOspa
dc.subject.keywordGenotypespa
dc.subject.keywordObesityspa
dc.subject.keywordObesityspa
dc.subject.keywordGenespa
dc.subject.keywordPopulationspa
dc.subject.keywordChildhoodspa
dc.subject.keywordVariantsspa
dc.subject.keywordChildrenspa
dc.subject.keywordWeightspa
dc.titleAsociación entre genotipos FTO (ns9939609) y marcadores de adiposidad en adultos chilenosspa
dc.title.TranslatedTitleAssociation between FTO (ns9939609) genotype and adiposity markers in Chilean adultseng
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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